数字农科院2.0

Exosomes Derived From Dendritic Cells Infected With Toxoplasma gondii Show Antitumoral Activity in a Mouse Model of Colorectal Cancer

文献类型： 外文期刊

作者： Lu, Jinmiao;Wei, Nana;Zhu, Shilan;Chen, Xiaoyu;Gong, Haiyan;Mi, Rongsheng;Huang, Yan;Chen, Zhaoguo;Li, Guoqing

作者机构：

关键词： Toxoplasma gondii;exosomes;myeloid derived suppressor cells (MDSCs);dendritic cells (DCs);colorectal cancer (CRC);immunosuppression

期刊名称： FRONTIERS IN ONCOLOGY

ISSN： 2234-943X

年卷期： 2022 年 12 卷

页码：

收录情况： SCIE（2022版）

摘要： Pathogen-based cancer therapies have been widely studied. Parasites, such as Toxoplasma gondii have elicited great interest in cancer therapy. Considering safety in clinical applications, we tried to develop an exosome-based immunomodulator instead of a live parasite for tumor treatment. The exosomes, called DC-Me49-exo were isolated from culture supernatants of dendritic cells (DCs) infected with the Me49 strain of T. gondii and identified. We assessed the antitumoral effect of these exosomes in a mouse model of colorectal cancer (CRC). Results showed that the tumor growth was significantly inhibited after treatment with DC-Me49-exo. Proportion of polymorphonuclear granulocytic bone marrow-derived suppressor cells (G-MDSCs, CD11b(+)Ly6G(+)) and monocytic myeloid-derived suppressor cells (M-MDSCs, CD11b(+)Ly6C(+)) were decreased in the DC-Me49-exo group compared with the control groups in vitro and in vivo. The proportion of DCs (CD45(+)CD11c(+)) increased significantly in the DC-Me49-exo group. Levels of interleukin-6 (IL-6) and granulocyte-macrophage colony-stimulating factor (GM-CSF) significantly decreased after treatment with DC-Me49-exo. Furthermore, we found that DC-Me49-exo regulated the lever of MDSC mainly by inhibiting the signal transducer and activator of transcription (STAT3) signaling pathway. These results indicated that exosomes derived from DCs infected with T. gondii could be used as part of a novel cancer therapeutic strategy by reducing the proportion of MDSCs.

分类号：

  • 相关文献

[1]Investigation of the immunomodulatory effects and molecular mechanisms of cichoric acid on cyclophosphamide-induced immunosuppression in mice. Bai, Lixia,Feng, Chenjing,Xu, Xiao,Ge, Wenbo,Yang, Yajun,Liu, Xiwang,Li, Zhun,Qin, Zhe,Li, Shihong,Li, Jianyong. 2025

[2]Interleukin 10 Suppresses the Function of Mouse Bone Marrow-Derived Dendritic Cells Infected with Classical Swine Fever Virus C-Strain. Zheng, Fu-Ying,Lin, Guo-Zhen,Jing, Zhi-Zhong. 2013

[3]Deletion of the BAC sequences from recombinant meq-null Marek's disease (MD) virus increases immunosuppression while maintaining protective efficacy against MD. Su, S.,Cui, N.,Sun, P.,Cui, Z.,Li, J.,Li, H.,Li, Y..

[4]Interaction of infectious bursal disease virus with the immune system of poultry. Rehman, Z. U.,Meng, C.,Ding, C.,Rehman, Z. U.,Umar, S.,Umar, S.,Munir, M..

[5]NE Strengthens the Immunosuppression Induced by AlCl3 Through beta(2)-AR/cAMP Pathway in Cultured Rat Peritoneal Macrophages. Li, Miao,Yang, Xu,Zhuang, Cuicui,Cao, Zheng,Ren, Limin,Xiu, Chunyu,Li, Yanfei,Zhu, Yanzhu.

[6]Cordyceps militaris polysaccharides can enhance the immunity and antioxidation activity in immunosuppressed mice. Wang, Mi,Qin, Tao,Hu, Yuan Liang,Wang, Mi,Meng, Xin Yu,Le Yang, Rui,Wang, Xiao Yang,Zhang, Ke Yu,Fei, Chen Zhong,Li, Ying,Xue, Fei Qun.

[7]Dietary supplementation with American ginseng dietary fiber ameliorates intestinal mucosal barrier injury in immunosuppressed mice. Jiyue Sha,Zhengbo Liu,Hongxia Yu,Xiaohui Huo,Jiajia Wang,Yuanyuan Duan,Wei Li,Di Qu,Zhiman Li,Jianbo Chen,Xueqing Li,Yinshi Sun. 2023

[8]Persistent and Severe Viral Replication in PBMCs with Moderate Immunosuppression Served an Alternative Novel Pathogenic Mechanism for Canine Morbillivirus. Feng C.,Bu Y.,Cai J.,Zhao G.,Li Z.,Cheng Y.,Zhang X.,Shi Y.,Gao Y.,Li X.,Zheng X.,Xue X.. 2023

[9]American ginseng with different processing methods ameliorate immunosuppression induced by cyclophosphamide in mice via the MAPK signaling pathways. Zhang Y.-T.,Tian W.,Lu Y.-S.,Li Z.-M.,Ren D.-D.,Zhang Y.,Sha J.-Y.,Huo X.-H.,Li S.-S.,Sun Y.-S.. 2023

[10]Structure of African Swine Fever Virus and Associated Molecular Mechanisms Underlying Infection and Immunosuppression: A Review. Yue Wang,Weifang Kang,Wenping Yang,Jing Zhang,Dan Li,Haixue Zheng. 2021

[11]Differences in Pathogenicity and Vaccine Resistance Discovered between Two Epidemic Strains of Marek’s Disease Virus in China. Zheng Hao Yu,Yan Ping Zhang,Xing Ge Lan,Ya Nan Wang,Rong Rong Guo,Kai Li,Li Gao,Xiao Le Qi,Hong Yu Cui,Xiao Mei Wang,Yu Long Gao,Chang Jun Liu. 2023

[12]Immunomodulatory Effect of Ginsenoside Rb2 Against Cyclophosphamide-Induced Immunosuppression in Mice. Siwen Zheng,Housheng Zheng,Rui Zhang,Xiangmin Piao,Junnan Hu,Yanzhu Zhu,Yingping Wang. 2022

[13]Ginseng-DF ameliorates intestinal mucosal barrier injury and enhances immunity in immunosuppressed mice by regulating MAPK/NF-κB signaling pathways. Sha, Ji-yue,Chen, Ke-Cheng,Liu, Zheng-bo,Li, Wei,Lu, Yu-shun,Liu, Shuang,Ma, Jian-kai,Qu, Di,Sun, Yin-shi. 2024

[14]Expression characteristics of miR-222b-5p/MAPK10 in major immune organs of SPF chickens infected with avian reticuloendotheliosis virus strain SNV (REV-SNV). Zhao, Yubo,Zhang, Qing,Wu, Bingrong,Zhu, Yudong,Ren, Hui,Diao, Youxiang,Tang, Yi,Hu, Jingdong. 2025

[15]The Molecular Drivers of Honey Robbing in Apis mellifera L.: Morphological Divergence and Oxidative-Immune Regulation Mechanisms Based on Proteomic Analysis. Xinyu Wang,Xijie Li,Zhanfeng Yan,Mengjuan Hao,Xiao Cui,Zhenxing Liu,Jun Guo,Yazhou Zhao. 2025

[16]The Mutated Very Virulent IBDV (mvvIBDV) Suppresses Immune Responses to Avian Influenza and Newcastle Disease Immunization. Hangbo Yu , Dan Ling , Ziwen Wu , Chen He , Guodong Wang , Jingli Liu , Mengmeng Huang , Yulong Zhang , Runhang Liu , Erjing Ke , Xianyun Liu , Suyan Wang , Hongyu Cui , Yanping Zhang , Yuntong Chen , Yongzhen Liu , Yulu Duan , Xianying Zeng , Yulong Gao , Xiaole Qi. 2025

[17]Selenomethionine Mitigates Oxidized Soybean Oil-Induced Jejunal Injury via Antioxidant, Metabolic Reprogramming, and Immunomodulatory Pathways. Huihui Tian,Luxi Lin,Pingyang Li,Yiyu Yin,Kehan Ma,Qingyu Zhao,Junmin Zhang,Chaohua Tang. 2025

[18]Global profiling of miRNA and protein expression patterns in rabbit peritoneal macrophages treated with exosomes derived from Taenia pisiformis cysticercus. Wang, Liqun,Liu, Tingli,Pu, Guiting,Chen, Guoliang,Li, Hong,Zhang, Shaohua,Li, Yanping,Luo, Xuenong. 2023

[19]Comparative Study of the Expression Profiles of miRNAs of Milk-Derived Exosomes of Yak and Jeryak. Wenwen Ren,Yongfeng Zhang,Renqing Dingkao,Chun Huang,Xiaoming Ma,Xiaoyun Wu,Yongfu La,Min Chu,Pengjia Bao,Xian Guo,Jie Pei,Ping Yan,Chunnian Liang. 2022

[20]Intercellular Transmission Of Seneca Valley Virus Mediated By Exosomes. Xu, GW, Xu, SX, Shi, XJ, Shen, CC, Hao, JH, Yan, MH, Zhang, DJ, Zhu, ZX, Zhang, KS, Zheng, HX, Liu, XT. 2020

作者其他论文 更多>>