数字农科院2.0

Role of feline ANP32 proteins in regulating polymerase activity of influenza A virus

文献类型： 外文期刊

作者： Lu G.;Zheng F.;Xiao Y.;Shao R.;Ou J.;Yin X.;Li S.;Zhang G.

作者机构：

关键词： ANP32;cross-species transmission;feline;influenza A virus

期刊名称： Journal of Integrative Agriculture

ISSN： 2095-3119

年卷期： 2024 年 23 卷 9 期

页码：

收录情况： SCIE（2024版） ; ; CSCD（2023-2024年度） ; ; 科技核心（2024版） ; ; 农林核心（2020版）

摘要： Recently, increasing natural infection cases and experimental animal challenge studies demonstrated domestic cats are susceptible to multiple subtypes influenza A virus (IAV) infections. Notably, some subtype IAV strains could circulate in domestic cats after cross-species transmission and even infected humans, posing a threat to public health. Host factors related to viral polymerase activity could determine host range of IAV and acidic nuclear phosphoprotein 32 (ANP32) is the most important one among them. However, role of cat-derived ANP32 on viral polymerase activity and host range of IAV is still unknown. In the present study, a total of 10 feline ANP32 (feANP32) splice variants (including 5 feANP32A, 3 feANP32B, and 2 feANP32E) were obtained from domestic cats by RT-PCR. Sequence alignment results demonstrated amino acid deletions and/or insertions occurred among feANP32 variants, but all feANP32 proteins were primarily localized to cell nucleus. Minigenome replication systems for several representative IAV strains were established and the support ability of feANP32 on IAV polymerase activity was estimated. The results indicated that most feANP32A and feANP32B splice variants were able to support all the tested IAV strains, though the support activity of a single feANP32 protein on polymerase activity varied among different IAV strains. In addition, the role of feANP32 in supporting H3N2 canine influenza virus was determined by investigating viral replication in vitro. Collectively, our study systematically investigated the support activity of feANP32 on IAV, providing a clue for further exploring the mechanism of susceptibility of cats to IAV. © 2024 CAAS. Published by Elsevier B.V

分类号：

  • 相关文献

[1]Viral metagenomics unveiled extensive communications of viruses within giant pandas and their associated organisms in the same ecosystem. Min Zhao,Chanjuan Yue,Zijun Yang,Yunli Li,Dongsheng Zhang,Ju Zhang,Shixing Yang,Quan Shen,Xiaoyan Su,Dunwu Qi,Rui Ma,Yuqing Xiao,Rong Hou,Xia Yan,Lin Li,Yanshan Zhou,Jiabin Liu,Xiaochun Wang,Wei Wu,Wen Zhang,Tongling Shan,Songrui Liu. 2022

[2]Characterization of parainfluenza virus 5 from diarrheic piglet highlights its zoonotic potential. Ibrahim, Yassein M.,Zhang, Wenli,Werid, Gebremeskel Mamu,Zhang, He,Pan, Yu,Zhang, Lin,Xu, Yunfei,Li, Changwen,Chen, Hongyan,Wang, Yue. 2022

[3]Virome of Giant Panda-Infesting Ticks Reveals Novel Bunyaviruses and Other Viruses That Are Genetically Close to Those from Giant Pandas. Ma, Rui,Zhao, Min,Wang, Haoning,Hou, Rong,Qin, Kailin,Qian, Yu,Zhang, Han,Zhou, Yanshan,Wu, Wei,Gu, Jiang,Wang, Xiaochun,Shen, Quan,Liu, Songrui,Liu, Jiabin,Bi, Wenlei,Yu, Xiang,Yang, Shixing,Feng, Feifei,Li, Zusheng,Zhang, Long,Lan, G. 2022

[4]The function of feline stimulator of interferon gene (STING) is evolutionarily conserved. Zhang, Xiaozhan,Wu, Hongxia,Liu, Chunguo,Sun, Xue,Zu, Shaopo,Tian, Jin,Qu, Liandong,Li, Shoujun,Sun, Xue,Zu, Shaopo,Li, Shoujun.

[5]Investigating Influenza Virus Polymerase Activity in Feline Cells Based on the Influenza Virus Minigenome Replication System Driven by the Feline RNA Polymerase I Promoter. Lu, Gang,Zheng, Feiyan,Ou, Jiajun,Yin, Xin,Li, Shoujun. 2022

[6]Correlation Between MicroRNA by Extracellular Vesicle Mediated and Antiviral Effects of Interferon Omega in Feline Peripheral Blood. Mingxing Yang,Guowei Xu,Jingyan Zhang,Zhiting Guo,Chao Liang,Yajun Li,Lei Wang,Yuxia Zhou,Yi Ru,Jianxi Li,Xuezhi Wang,Yan Sun. 2024

[7]Rapid detection of feline parvovirus using RAA-CRISPR/Cas12a-based lateral flow strip and fluorescence. Han Chen,Hailing Zhang,Jie Guo,Xiangshu Meng,Mengfan Yao,Longbin He,Xiaoxuan Nie,Han Xu,Chao Liu,Jian Sun,Fei Wang,Yuelong Sun,Zhong Jiang,Yanliang He,Jianlou Zhang,Jianke Wang. 2025

[8]Insights into the structural features of a feline CD8αα homodimer. Rui Ying Liang,Yu Die Cao,Yong Yu Gao,Hai Yang Li,Chen Jun Sang,Yu He Xiu,Dan Li,Da Zhong Liu,Feng Shan Gao,Zi Bin Li. 2025

[9]The non-structural (NS1) protein of influenza A virus associates with p53 and inhibits p53-mediated transcriptional activity and apoptosis. Wang, Xiaodu,Shen, Yang,Qiu, Yafeng,Shi, Zixue,Shao, Donghua,Chen, Peijun,Tong, Guangzhi,Ma, Zhiyong,Qiu, Yafeng,Shao, Donghua,Ma, Zhiyong. 2010

[10]Influenza a virus NS1 protein induced A20 contributes to viral replication by suppressing interferon-induced antiviral response. Feng, Wenjing,Sun, Xiaoning,Zhang, Maolin,Guan, Zhenhong,Duan, Ming,Shi, Ning.

[11]Structural Definition of Duck Major Histocompatibility Complex Class I Molecules That Might Explain Efficient Cytotoxic T Lymphocyte Immunity to Influenza A Virus. Wu, Yanan,Wang, Junya,Fan, Shuhua,Chen, Rong,Liu, Yanjie,Zhang, Jianhua,Yuan, Hongyu,Liang, Ruiying,Zhang, Nianzhi,Xia, Chun,Liu, Yanjie,Xia, Chun.

[12]Impacts of different expressions of PA-X protein on 2009 pandemic H1N1 virus replication, pathogenicity and host immune responses. Leea, Jinhwa,Yua, Hai,Li, Yonghai,Ma, Jingjiao,Lang, Yuekun,Duff, Michael,Henningson, Jamie,Liu, Qinfang,Li, Yuhao,Nagy, Abdou,Bawa, Bhupinder,Richt, Juergen A.,Ma, Wenjun,Yua, Hai,Liu, Qinfang,Li, Zejun,Tong, Guangzhi,Nagy, Abdou.

[13]Honeysuckle-encoded atypical microRNA2911 directly targets influenza A viruses. Zhou, Zhen,Li, Xihan,Dong, Lei,Chen, Qun,Liu, Jialing,Hou, Dongxia,Zhang, Lin,Liu, Yuchen,Zhang, Yujing,Li, Jing,Wang, Jin,Chen, Xi,Zhang, Junfeng,Zen, Ke,Zhang, Chen-Yu,Liu, Jinxiong,Kong, Huihui,Zhang, Qianyi,Zhang, Guoquan,Qi, Xian,Wang, Hua. 2015

[14]Subtyping of type A influenza by sequencing the variable regions of HA gene specifically amplified with RT-PCR. Yan An,Zhou ZhenFeng,Dong Hui,Zhang YaKun,Jin Li,Zhao GuoPing,Xiong Hui,Zhu Lei,He YunGang,Zhao GuoPing,Jin WeiRong,Zhang GuoQing,Li YiXue,Yang Zhong,Zhong Yang,Cao ZhiWei,Jin Li,Wang HongYan,Wang XiaoNing,Yang Zhong,Zhong Yang,Zhao GuoPing,Wang XiaoNing,Dai JianXin,Guo YaJun,Wang Hao,Dai JianXin,Guo YaJun,Wang Hao,Che XiaoYan,Wu Fan,Yuan ZhenGan,Zhang Xi,Cao ZhiWei,Zhou XiaoNong,Zhou JiaHai,Ma ZhiYong,Tong GuangZhi,Ding GuoHui,Li YiXue,Sun Bing,Huang Zhong,Lan Ke,Jin Li,Zhao GuoPing,Ding GuoHui,Li YiXue,Sun Bing,Huang Zhong,Lan Ke,Jin Li,Zhao GuoPing,Ding GuoHui,Li YiXue,Sun Bing,Huang Zhong,Lan Ke,Jin Li,Zhao GuoPing,Ding GuoHui,Li YiXue,Sun Bing,Huang Zhong,Lan Ke,Jin Li,Zhao GuoPing,Ding GuoHui,Li YiXue,Sun Bing,Huang Zhong,Lan Ke,Jin Li,Zhao GuoPing. 2009

[15]Neuraminidase inhibiting antibody responses in pigs differ between influenza A virus N2 lineages and by vaccine type. Sandbulte, Matthew R.,Roth, James A.,Kitikoon, Pravina,Vincent, Amy L.,Gauger, Phillip C.,Chen, Hongjun,Perez, Daniel R.,Sandbulte, Matthew R.,Kitikoon, Pravina,Chen, Hongjun,Perez, Daniel R..

[16]A PB1 T296R substitution enhance polymerase activity and confer a virulent phenotype to a 2009 pandemic H1N1 influenza virus in mice. Yu, Zhijun,Qin, Chuan,Xia, Xianzhu,Yu, Zhijun,Qin, Chuan,Xia, Xianzhu,Yu, Zhijun,Sun, Weiyang,Zhang, Xinghai,Li, Yuanguo,Wang, Tiecheng,Wang, Hualei,Xin, Yue,Li, Xue,Zhang, Kun,Huang, Jing,Yang, Songtao,Gao, Yuwei,Xia, Xianzhu,Cheng, Kaihui,Zhang, Qianyi,Chen, Hualan,Wilker, Peter R.,Yue, Donghui,Gao, Yuwei,Xia, Xianzhu,Xia, Xianzhu.

[17]An M2e-based synthetic peptide vaccine for influenza A virus confers heterosubtypic protection from lethal virus challenge. Ma, Ji-Hong,Yang, Fu-Ru,Yu, Hai,Zhou, Yan-Jun,Li, Guo-Xin,Huang, Meng,Wen, Feng,Tong, Guangzhi. 2013

[18]Type I interferon-mediated immune response against influenza A virus is attenuated in the absence of p53. Zhu, Zixiang,Yang, Yifan,Wei, Jianchao,Shao, Donghua,Shi, Zixue,Li, Beibei,Liu, Ke,Qiu, Yafeng,Ma, Zhiyong,Zhu, Zixiang,Zheng, Haixue.

[19]PLC-gamma 1 is involved in the inflammatory response induced by influenza A virus H1N1 infection. Xu, Shuai,Yang, Jiayun,Zhu, Qiyun,Zhu, Liqian,Yuan, Chen,Ding, Xiuyan,Zhu, Liqian,Yuan, Chen,Ding, Xiuyan,Liang, Yuying.

[20]Simultaneous detection of novel H7N9 and other influenza A viruses in poultry by multiplex real-time RT-PCR. Xu, Xiaolong,Bao, Hongmei,Ma, Yong,Sun, Jiashan,Zhao, Yuhui,Wang, Yunhe,Shi, Jianzhong,Zeng, Xianying,Li, Yanbing,Wang, Xiurong,Chen, Hualan. 2015

作者其他论文 更多>>