数字农科院2.0

Fluorescence detection based on molecularly imprinted microspheres and graphene quantum dots/graphite carbon nitride for three tetracyclines determination in dairy products

文献类型： 外文期刊

作者： Yinchuan Pan;Shudong Liu;Hao Zhang;Youming Shen;Jing Liu;Jianping Wang;Yanxia Gao;Ning Ma

作者机构：

关键词： Fluorescence;Graphene quantum dots;Molecularly imprinted microspheres;Tetracyclines

期刊名称： LWT

ISSN： 0023-6438

年卷期： 2025 年 234 卷

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： Tetracyclines (TCs) residues in dairy products pose a potential threat to food safety and public health, necessitating sensitive and selective detection methods. In this study, a fluorescence-based sensing method was constructed by embedding nitrogen and phosphorus co-doped graphene quantum dots (NP-GQDs) into graphite carbon nitride (g-C3N4). The composite was subsequently combined with doxycycline-specific molecularly imprinted microspheres (MIM) to obtain MIM@NP-GQDs/g-C3N4. The composite-based assay exhibited a linear range of 2–50 ng/mL (R2 > 0.99), with detection limits of 0.8–1.8 ng/mL for three TCs. The method showed excellent reproducibility, allowing up to six reuse cycles, and recovery rates in TC-free dairy samples ranged from 83.5 % to 96.7 % (RSD <5 %). This study demonstrated the application of MIM@NP-GQDs/g-C3N4 for TC detection in dairy products, offering a highly selective and reusable fluorescence-based detection strategy.

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