数字农科院2.0

Global evolution dynamic of genotype VI NDVs and dissection of biological properties of strains from the prevalent sub-genotypes

文献类型： 外文期刊

作者： 邸涛;;韩宗玺;;李慧昕;;邵昱昊;;孙军峰;;刘胜旺

关键词： Newcastle disease virus; sub-genotype VI.2.1.1.2.2; genetic evolution; replication; virulence

期刊名称： Journal of Virology

ISSN： 0022-538X

年卷期： 2025 年

页码：

收录情况： SCIE（2025版）

摘要： As a unique antigenic variant of Newcastle disease virus (NDV) in pigeons, genotype VI NDVs cause serious disease in pigeons and pose a potential threat to domestic poultry. In this study, analyses of genetic variation and evolution of global genotype VI NDVs revealed the worldwide distribution and continuous evolution of genotype VI NDVs. Of importance, VI.2.1.1.2.1 and VI.2.1.1.2.2 are the two prevalent sub-genotypes worldwide. The virulence, replication capacity, and pathogenesis in chickens of representative strains from VI.2.1.1.2.1 and different clusters in VI.2.1.1.2.2 were further evaluated. Compared with the VI.2.1.1.2.1 strain, increased replication capacity and virulence in chickens were observed in strains of VI.2.1.1.2.2. VI.2.1.1.2.2 strains showed preferential binding for α-2,3-linked sialic acids and superior performance in viral entry, cell-cell fusion, and release of progeny virions. Evaluation with recombinant viruses demonstrated that residues at positions 365 and 497 in HN protein contributed to the differences in biological characteristics of VI.2.1.1.2.2 strains, and residue 365 was a key determinant. Moreover, our results showed that the activity of the viral replication complex contributed to the differences in replication capacity among these viruses, with the P protein being the major individual contributor. The optimal effect was achieved when the NP and L proteins were homologous. Moreover, the 5ꞌ terminal trailer region was also found involved in the replication capacity of genotype VI NDVs; however, viral V protein was not related to the replication and virulence of these viruses. Our findings highlight the potential risk of VI.2.1.1.2.2 NDVs due to their persistent circulation and evolution.

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