数字农科院2.0

Ultrasound-sensitized gas vesicles enable spatiotemporal therapeutics of solid tumors

文献类型： 外文期刊

作者： Li, Juanjuan;Liu, Yong;Jiang, Xiaoli;Han, Jiani;Tang, Yanqiong;Li, Hong;Ma, Xiang;Chi, Xue;Lin, Min;Liu, Zhu

作者机构：

关键词： Gas vesicles;Indocyanine green;Ultrasound;Spatiotemporal distribution;Photothermal therapy

期刊名称： CHEMICAL ENGINEERING JOURNAL

ISSN： 1385-8947

年卷期： 2025 年 527 卷

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： Inhomogeneous distribution and inadequate accumulation of antitumor drugs in solid tumors significantly limit their therapeutic effectiveness. There is a pressing need for methods that enable uniform and sustained delivery of therapeutics throughout these tumors. In this study, we present a gas vesicle-mediated therapeutic designed for spatiotemporal distribution in ultrasound-assisted photothermal therapy for solid tumors. Indocyanine green (ICG) is efficiently conjugated to the surface of gas vesicles through dopamine self-polymerization, which demonstrates enhanced photothermal stability and a high photothermal conversion efficiency of similar to 35%, together with an approximately 2-fold higher reactive oxygen species generation than free ICG. Following ultrasound treatment, the biohybrids can fragment and infiltrate solid tumors, achieving homogeneous distribution and retention within the tumor. This targeted spatiotemporal delivery leads to significant suppression of tumor growth and extended survival in tumor-bearing mice. Additionally, due to their capacity to disrupt ribosomes and recruit immune cells, these well-designed nano biohybrids offer a viable approach for the effective spatiotemporal distribution of drugs in solid tumors, thereby enhancing antitumor efficacy with high efficiency.

分类号：

  • 相关文献

[1]Injectable and Temperature-Sensitive Titanium Carbide-Loaded Hydrogel System for Photothermal Therapy of Breast Cancer. Jun Yao,Chuanda Zhu,Tianjiao Peng,Qiang Ma,Shegan Gao. 2021

[2]Spatiotemporal distribution, sources apportionment and ecological risks of PAHs: a study in the Wuhan section of the Yangtze River. Chen, Yulin,Song, Ranran,Li, Ping,Wang, Yile,Tan, Yang,Ma, Yongfei,Yang, Lie,Wu, Li,Du, Zhenjie,Qi, Xuebin,Zhang, Zulin. 2023

[3]Impact of active root zone soil potassium levels on cotton yield and fiber quality under no tillage. Jingjing Shao,Aizhong Liu,Helin Dong,Pengcheng Li,Miao Sun,Weina Feng,Feichao Huo,Cangsong Zheng. 2024

[4]Refining Lineage Classification and Updated RFLP Patterns of PRRSV-2 Revealed Viral Spatiotemporal Distribution Characteristics in China in 1991-2023. Tian, Xiaoxiao,Wei, Ziyi,Khan, Mirwaise,Zhou, Zhi,Zhang, Jianqiang,Huang, Xinyi,Yang, Yongbo,Wang, Shujie,Wang, Haiwei,Cai, Xuehui,Meng, Fandan,An, Tongqing. 2025

[5]Effects of microwave and ultrasound pretreatments on enzymolysis of milk protein concentrate with different enzymes. Uluko, Hankie,Zhang, Shuwen,Liu, Lu,Chen, Jianhang,Sun, Yanjun,Su, Yanling,Li, Hongjuan,Cui, Wenming,Lv, Jiaping,Uluko, Hankie. 2013

[6]Response surface optimization of angiotensin converting enzyme inhibition of milk protein concentrate hydrolysates in vitro after ultrasound pretreatment. Uluko, Hankie,Li, Hongjuan,Cui, Wenming,Zhang, Shuwen,Liu, Lu,Chen, Jianhang,Sun, Yanjun,Su, Yanling,Lv, Jiaping,Uluko, Hankie. 2013

[7]Pilot-scale membrane fractionation of ACE inhibitory and antioxidative peptides from ultrasound pretreated milk protein concentrate hydrolysates. Uluko, Hankie,Zhang, Shuwen,Liu, Lu,Li, Hongjuan,Cui, Wenming,Xue, Haixiao,Zhao, Lili,Lu, Jing,Lv, Jiaping,Uluko, Hankie,Sun, Yanjun. 2014

[8]Optimisation for resveratrol accumulation during peanut germination with phenylalanine feeding & ultrasound-treatment using response surface methodology. Yu, Miao,Yu, Miao,Liu, Hongzhi,Yang, Ying,Shi, Aimin,Liu, Li,Hui, Hui,Wang, Qiang,Yu, Miao. 2016

[9]Combination of salicylic acid and ultrasound to control postharvest blue mold caused by Penicillium expansum in peach fruit. Cao, Shifeng,Yang, Zhenfeng,Cai, Yuting,Zheng, Yonghua.

[10]Preparation of resveratrol-enriched and poor allergic protein peanut sprout from ultrasound treated peanut seeds. Yu, Miao,Liu, Hongzhi,Shi, Aimin,Liu, Li,Wang, Qiang,Yu, Miao,Yu, Miao.

[11]Effect of power ultrasound pretreatment on peptidic profiles and angiotensin converting enzyme inhibition of milk protein concentrate hydrolysates. Uluko, Hankie,Liu, Lu,Li, Hongjuan,Cui, Wenming,Zhang, Shuwen,Zhao, Lili,Xue, Haixiao,Lv, Jiaping,Uluko, Hankie.

[12]Combined Salicyclic Acid and Ultrasound Treatments for Reducing the Chilling Injury on Peach Fruit. Yang, Zhenfeng,Yang, Zhenfeng,Jiang, Yueming,Cao, Shifeng,Zheng, Yonghua.

[13]Effect of ultrasound pretreatment on rennet-induced coagulation properties of goat's milk. Zhao, Lily,Zhang, Shuwen,Uluko, Hankie,Liu, Lu,Lu, Jing,Xue, Haixiao,Kong, Fanhua,Lv, Jiaping.

[14]Study on the Effect of Ultrasound on the Secondary Structure of BSA by FTIR. Liu Bin,Ma Hai-le,Li Shu-jun,Zhao Wei-rui,Ma Hai-le,Li Shu-jun,Li Lin. 2010

[15]The effects of ultrasound and arsenic trioxide on neurogliocytoma cells and secondary activation of macrophages. Xu, Yonggang,Liu, Xiaoqian,Wang, Zhi,Yue, Wu,Wang, Jie,Zhang, Yafang,Ma, Jing. 2009

[16]Effect of ultrasound treatment on fruit decay and quality maintenance in strawberry after harvest. Cao, Shifeng,Hu, Zhichao,Pang, Bin,Wang, Haiou,Xie, Huanxiong,Wu, Feng.

[17]Ultrasound Treatment Enhanced Semidry-Milled Rice Flour Properties and Gluten-Free Rice Bread Quality. Wanyu Qin,Huihan Xi,Aixia Wang,Xue Gong,Zhiying Chen,Yue He,Lili Wang,Liya Liu,Fengzhong Wang,Litao Tong. 2022

[18]Structural, antioxidant, aroma, and sensory characteristics of Maillard reaction products from sweet potato protein hydrolysates as influenced by different ultrasound-assisted enzymatic treatments. Ildephonse Habinshuti,Tai-Hua Mu,Miao Zhang. 2021

[19]Quality of fresh and fresh-cut produce impacted by nonthermal physical technologies intended to enhance microbial safety. Xuetong Fan,Wenli Wang. 2021

[20]Recent advances in frying processes for plant-based foods. Abdulla Al Faruq,Mst Husne Ara Khatun,S. M.Roknul Azam,Md Sazzat Hossain Sarker,Md Sultan Mahomud,Xin Jin. 2022

作者其他论文 更多>>