数字农科院2.0

Viral replication organelles: the highly complex and programmed replication machinery

文献类型： 外文期刊

作者： Hao Deng;Hongwei Cao;Yanjin Wang;Jiaqi Li;Jingwen Dai;Lian Feng Li;Hua Ji Qiu;Su Li

作者机构：

关键词： antiviral drugs;DNA sliding clamp;viral DNA ligase;viral helicase;viral polymerase;viral replication organelles

期刊名称： Frontiers in Microbiology

ISSN： 1664-302X

年卷期： 2024 年 15 卷

页码：

收录情况： SCIE（2024版）

摘要： Viral infections usually induce the rearrangement of cellular cytoskeletal proteins and organelle membrane structures, thus creating independent compartments [termed replication organelles (ROs)] to facilitate viral genome replication. Within the ROs, viral replicases, including polymerases, helicases, and ligases, play functional roles during viral replication. These viral replicases are pivotal in the virus life cycle, and numerous studies have demonstrated that the viral replicases could be the potential targets for drugs development. Here, we summarize primarily the key replicases within viral ROs and emphasize the advancements of antiviral drugs targeting crucial viral replicases, providing novel insights into the future development of antiviral strategies.

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