数字农科院2.0

Metabolic Reprogramming of Adaptive Immunity Induced by Viral Infections

文献类型： 外文期刊

作者： Tong, Guoshuai;Dai, Jingwen;Liu, Qianqian;Gao, Xu;Li, Su;Qiu, Hua-Ji

作者机构：

关键词： adaptive immunity;immune regulation;immunotherapy;metabolic reprogramming;viral infections

期刊名称： IMMUNOLOGY

ISSN： 0019-2805

年卷期： 2025 年

页码：

收录情况： SCIE（2025版）

摘要： Metabolic reprogramming induced by viral infections plays a key role in shaping the efficacy and durability of the host's adaptive immune response. Notably, metabolic reprogramming not only directly governs the differentiation fates of functional subgroups, such as Th1, Th2, Th17, Treg and cytotoxic T cells, but also contributes to supportive immune responses and T-cell exhaustion mediated by metabolic disorders in the context of acute and chronic infections, respectively. Moreover, the metabolic reprogramming of B cells precisely regulates their germinal centre response, plasma cell differentiation and antibody production, thereby modulating the intensity and quality of humoral immunity. Beyond these direct effects, viruses indirectly impair the functionality of T and B cells by altering the metabolic status of innate immune cells such as dendritic cells and macrophages. This review summarises the recent advances of regulatory mechanisms regarding metabolic characteristics of T cells and B cells at various statuses, including rest, activation, differentiation and memory, and discusses immune intervention strategies targeting glycolysis, glutamine and lipid metabolism, and outlines future research directions and clinical translation potential of metabolic reprogramming. A comprehensive understanding of virus-mediated metabolic reprogramming will provide an important theoretical basis for the development of new antiviral therapies and immunotherapy strategies.

分类号：

  • 相关文献

[1]Cellular metabolism hijacked by viruses for immunoevasion: potential antiviral targets. Li, Jiaqi,Wang, Yanjin,Deng, Hao,Li, Su,Qiu, Hua-Ji. 2023

[2]Antiviral Effects and Underlying Mechanisms of Probiotics as Promising Antivirals. Wang, Yanjin,Moon, Assad,Huang, Jingshan,Sun, Yuan,Qiu, Hua-Ji. 2022

[3]The multifaceted roles of selective autophagy receptors in viral infections. Luo, Rui,Wang, Tao,Lan, Jing,Lu, Zhanhao,Chen, Shengmei,Sun, Yuan,Qiu, Hua-Ji. 2024

[4]Organoids: physiologically relevant ex vivo models for viral disease research. Wang, Yijing,Peng, Dingkun,Li, Meilin,Yao, Meng,Li, Tianlong,Li, Su,Qiu, Hua-Ji,Li, Lian-Feng. 2025

[5]Multi-Omics Profiling Reveals Se Deficiency-Induced Redox Imbalance, Metabolic Reprogramming, and Inflammation in Pig Muscle. Zhang, Kai,Li, Shuang,Zhao, Qingyu,Li, Jing,Han, Yunsheng,Qin, Yuchang,Zhang, Junmin,Tang, Chaohua. 2022

[6]Pathogen-derived peptidoglycan skeleton enhances innate immune defense against Staphylococcus aureus via mTOR-HIF-1α-HK2-mediated trained immunity. Zheng Jia,Lingdi Niu,Junjie Guo,Jiaqing Wang,Hai Li,Runhang Liu,Ning Liu,Shuhe Zhang,Fang Wang,Junwei Ge. 2025

[7]A pathogen peptidoglycan scaffold coated with artificial biomembrane promotes broad resistance to bacterial infections by dynamically reprogramming macrophage metabolism. Junjie Guo,Shuo Jia,Zibo Mai,Chaonan Wang,Zheng Jia,Jiaqing Wang,Xinran Yao,Jiaqi Liu,Fang Wang,Junwei Ge. 2025

[8]Immunity Against Hepatitis E Virus I.nfection: Implications For Therapy A nd Vaccine Development. Hakim, MS, Ikram, A, Zhou, JH, Wang, WS, Peppelenbosch, MP, Pan, QW. 2018

[9]Evasion of host defense by Brucella. Yang J.,Wang Y.,Hou Y.,Sun M.,Xia T.,Wu X.. 2024

[10]How to Break through the Bottlenecks of in Ovo Vaccination in Poultry Farming. Li X.,Liu X.,Cui L.,Liu Z.,Zhang Y.,Li H.. 2024

[11]Single-cell RNA sequencing reveals T and B cell-related immune features in foot and mouth disease virus-infected mice. Yang Wang,Lihong Zhang,Zhao Zhang,Zhihua Chen,Jingru Xu,Han Zhang,Haixue Zheng,Jingjing Pei. 2025

[12]TLR agonists as adjuvants for viral vaccines: mechanisms, applications, and future directions. Shao, Fengyan,Zhu, Xiangyu,Yi, Ming,Gao, Hongyu,Wu, Jiali,Fang, Ruikang,Xie, Yubiao,Han, Jicheng,Lu, Huijun. 2026

[13]Outer Membrane Vesicles Attenuate Klebsiella pneumoniae Infection Injury by Affecting Macrophage Polarisation and Helper T Cell Differentiation. Wei Fan,Wei Wang,Lin Kong,Shifan Chen,Xinyu Zhang,Yilu Zhai,Bo Zhang,Yan Wang,Dazhuo Zhao,Xiukai Tang,Jiaqi Fu,Fuliang Sun. 2025

[14]Rna‐seq analysis of influenza a virus‐induced transcriptional changes in mice lung and its possible implications for the virus pathogenicity in mice. Tianxin Ma,Abdou Nagy,Guanlong Xu,Lingxiang Xin,Danqi Bao,Chenyang Lu,Shiqi Niu,Zihua Wu,Chaochao Ren,Ting Zhang,Jianmei Yang,Qiaoyang Teng,Xuesong Li,Zejun Li,Qinfang Liu. 2021

[15]Single-sex schistosomiasis: a mini review. Zhong, Haoran,Jin, Yamei. 2023

[16]Study about the combination strategy of Bacillus subtilis wt55 with AiiO-AIO6 to improve the resistance of zebrafish to Aeromonas veronii infection. Yuan Yuan Yao,Rui Xia,Ya Lin Yang,Qiang Hao,Chao Ran,Zhen Zhang,Zhi Gang Zhou. 2022

[17]Immunomodulatory Effect of Ginsenoside Rb2 Against Cyclophosphamide-Induced Immunosuppression in Mice. Siwen Zheng,Housheng Zheng,Rui Zhang,Xiangmin Piao,Junnan Hu,Yanzhu Zhu,Yingping Wang. 2022

[18]Immunomodulatory Effects of Lactiplantibacillus plantarum Strain RW1 During Salmonella Infection in Murine Intestinal Epithelial Cells and Dextran Sulfate Sodium-Induced Murine Colitis. Zhang, Guangzhi,Raheem, Abdul,Xu, Xiaofeng,Fan, Xuezheng,Zhang, Jianwei,Qin, Tong,Jia, Li,Yue, Min,Yang, Weifang,Wang, Liang,Wang, Mingyan,Yin, Yajie,Li, Qiuchen,Jiang, Ying,Tian, Ye,Jiang, Hui,Xin, Ting,Ding, Jiabo. 2024

[19]The Candida quercitrusa strain Cq-C08 induces plant resistance to root-knot nematodes. Lu, Cuihua,Li, Erfeng,Liu, Rui,Chang, Nv,Lai, Yuqing,Wu, Yue,Wu, Weilong,Chen, Zhukan,Ling, Jian,Zhao, Jianlong,Mao, Zhenchuan. 2025

[20]The combined effects of 2′-fucosyllactose and 6′-sialyllactose on immune function and gut microbiota in healthy mice. Kejue Feng,Zicun Lin,Jinhui Du,Zhenxia Xu,Xia Xiang,Hao Shi. 2025

作者其他论文 更多>>