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LC–MS/MS-guided discovery of japonamides C and D, two new cyclohexadepsipeptides, from the Nicotiana tabacum-derived endophytic fungus Aspergillus japonicus TE-739D

文献类型： 外文期刊

作者： Haisu Wang;Xianwei Hao;Chen Dong;Xiaolong Yuan;Peng Zhang;Gan Gu

作者机构：

关键词： Aspergillus japonicas;cell proliferation inhibitory activity;cyclohexadepsipeptides;endophytic fungus;japonamides

期刊名称： Frontiers in Microbiology

ISSN： 1664-302X

年卷期： 2025 年 16 卷

页码：

收录情况： SCIE（2025版）

摘要： Endophytic fungi belonging to the Aspergillus genus have received substantial attention due to their notable secondary metabolic potential. In this study, chemical investigations using LC–MS/MS-based molecular networking on the endophytic fungus Aspergillus japonicus TE-739D led to the discovery of two new cyclohexadepsipeptides, namely japonamides C (1) and D (2), along with three known cyclodipeptides (3–5). Their structures, including the absolute configurations of the amino acid residues, were elucidated through spectroscopic data analysis and an optimized Marfey’s method. The newly discovered compounds, japonamides C (1) and D (2), were screened for broad-spectrum cell proliferation inhibitory activity against 20 different human cell lines. The results indicated that both compounds displayed broad-spectrum antiproliferative activity against MKN-45, HCT116, TE-1, 5,637, CAL-62, and A-637 cells, with inhibition rates ranging from 55.0 to 72.3%. Moreover, the antibacterial activity of compounds 1–5 against two Gram-positive bacteria and two Gram-negative bacteria was also evaluated.

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