数字农科院2.0

Flavor Profile of 4-Isothiocyanato-1-butene in Microwave Rapeseed Oil and Its Anti-Inflammatory Properties In Vitro

文献类型： 外文期刊

作者： Xiang, Xia;Liu, Huihui;Zheng, Chang;Jiang, Nanjie;Huang, Fenghong;Zhou, Qi

作者机构：

关键词： rapeseed oil;4-isothiocyanato-1-butene;oxylipins;anti-inflammatory activities;signalingcascade

期刊名称： JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ISSN： 0021-8561

年卷期： 2025 年

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： 4-Isothiocyanato-1-butene (4-BITC) is a crucial plant isothiocyanate; however, its flavor profile in microwave rapeseed oil and its anti-inflammatory properties have not been elucidated in detail. Therefore, in this study, the distribution of 4-BITC in 45 rapeseed oils was quantitated using selected ion monitoring, with concentrations ranging from 0.29 to 8.63 mg/kg. The odor activity values ranged from 4 to 123. In a lipopolysaccharide (LPS)-induced RAW264.7 cell model, 4-BITC exerted dose-dependent anti-inflammatory effects, which resulted in remarkable differences in 20 lipid mediators between the LPS and 4-BITC groups. Kyoto Encyclopedia of Genes and Genomes analysis revealed that 4-BITC downregulated proinflammatory oxylipins by modulating the CYP, LOX, and COX pathways, thereby preventing arachidonic acid metabolism disorders. Molecular docking further confirmed that 4-BITC inhibited the PI3K/Akt/NF-kappa B signaling cascade to alleviate inflammation.

分类号：

  • 相关文献

[1]Ellagic acid-enhanced biocompatibility and bioactivity in multilayer core-shell gold nanoparticles for ameliorating myocardial infarction injury. Xina Yu,Jie Wang,Tiantian Wang,Shanshan Song,Hongna Su,Hui Huang,Pei Luo. 2024

[2]Minor components and oxidative stability of cold-pressed oil from rapeseed cultivars in China. Yang, Mei,Zheng, Chang,Zhou, Qi,Huang, Fenghong,Liu, Changsheng,Wang, Hui. 2013

[3]Micronutrients-fortified rapeseed oil improves hepatic lipid accumulation and oxidative stress in rats fed a high-fat diet. Xu, Jiqu,Deng, Qianchun,Huang, Qingde,Yang, Jin'e,Huang, Fenghong,Xu, Jiqu,Deng, Qianchun,Huang, Qingde,Yang, Jin'e,Huang, Fenghong,Zhou, Xiaoqi,Gao, Hui,Chen, Chang,Ma, Jing,Wan, Zhengyang. 2013

[4]Influence of Microwave Treatment of Rapeseed on Minor Components Content and Oxidative Stability of Oil. Yang, Mei,Huang, Fenghong,Liu, Changsheng,Zheng, Chang,Zhou, Qi,Wang, Hui. 2013

[5]Changes in the content of canolol and total phenolics, oxidative stability of rapeseed oil during accelerated storage. Zheng, Chang,Yang, Mei,Zhou, Qi,Liu, Chang-Sheng,Huang, Feng-Hong,Zheng, Chang.

[6]Effects of endogenous and exogenous micronutrients in rapeseed oils on the antioxidant status and lipid profile in high-fat fed rats. Deng, Qianchun,Yu, Xiao,Xu, Jiqu,Huang, Fenghong,Huang, Qingde,Liu, Changsheng,Deng, Qianchun,Yu, Xiao,Xu, Jiqu,Huang, Fenghong,Huang, Qingde,Liu, Changsheng,Wang, Lan,Ma, Fangli. 2014

[7]Influence of Microwaves Treatment of Rapeseed on Phenolic Compounds and Canolol Content. Yang, Mei,Zheng, Chang,Zhou, Qi,Liu, Changsheng,Li, Wenlin,Huang, Fenghong,Yang, Mei,Zheng, Chang,Zhou, Qi,Liu, Changsheng,Li, Wenlin.

[8]Rapeseed oil fortified with micronutrients reduces atherosclerosis risk factors in rats fed a high-fat diet. Xu, Jiqu,Deng, Qianchun,Huang, Qingde,Yang, Jin'e,Huang, Fenghong,Zhou, Xiaoqi. 2011

[9]Effect of rapeseed oil and beta-cyclodextrin coatings on the quality of eggs in shell. Dai, Yan,Chen, De-hui,Lei, Qin,Ren, Xiao-li,Li, Chun-hong,Zhang, Jing,Chang, Hai-jun. 2023

[10]Inhibitory effects and mechanisms of phenolic compounds in rapeseed oil on advanced glycation end product formation in chemical and cellular models in vitro. Huihui Liu,Ruiying Zhang,Wen Wang,Xiaoyang Xia,Zhenxia Xu,Xia Xiang. 2024

[11]Enzymatic Deacidification and Aroma Characteristics Analysis of Rapeseed Oil Using Self-Made Immobilized Lipase CALB@MCM-41-C8. Zhonghui Liu,Tieliang Liu,Run Liu,Qi Zhou,Yandaizi Zhou,Yi Zhang,Mingming Zheng. 2024

[12]Fluorescence spectroscopy combined with a multi-task deep learning model for rapeseed oil quality analysis. Xinna Jiang,Quancheng Liu,Xingda Cao,Fan Wang,Long Li,Lei Yan,Shuxiang Fan. 2025

[13]Comprehensive analysis of phenolic profile, their antioxidant activities, and physicochemical characteristics of rapeseed oil under various microwave and storage conditions. Yao Zhang,Zhixian Xiang,Rong Xia,Wenxi Chen,Xin Zhang,Hongting Lei,Fang Wei,Yongjun Yuan. 2025

[14]Relationship Between Rapeseed Oil Intake and Inflammatory Cytokines: Results from NHANES 2003-2006 and Mendelian Randomization. Duan, Xiaorui,Xu, Yaxi,Chen, Ze. 2025

作者其他论文 更多>>