数字农科院2.0

PHR-Mediated Pi Starvation Response Mobile Messenger RNAs Represent Noncoding Transcripts in Recipient Tissues

文献类型： 外文期刊

作者： Dong, Weiguo;Wang, Shuman;Liu, Chao;Qiao, Lulu;Liu, Kai;Jin, Qiongli;Mo, Xiaorong;Shen, Xingxing;Yi, Keke;Wang, Zhiye

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关键词： mRNA long-distance transport;noncoding transcripts;phosphate starvation response;PHR;RNA structure

期刊名称： ADVANCED SCIENCE

ISSN：

年卷期： 2025 年

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收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： Nutritional deficiency for phosphate (Pi) or nitrogen triggers long-distance transport of specific mobile mRNAs, but little is known about the underlying regulation, function, and structural features of these mobile nutrient starvation-specific mRNAs. Here, heterografting and high-throughput sequencing are used to explore the landscape of long-distance mRNA transport in Arabidopsis under normal and Pi-starvation conditions. Hundreds of Pi starvation response (PSR)-specific mobile mRNAs are discovered, although their abundance is constant between normal and Pi starvation conditions. The mobility of these PSR-specific mobile mRNAs is largely dependent on PHOSPHATE STARVATION RESPONSE (PHR) function, based on mutant analysis. Notably, translatome analysis and transgenic experiments reveal that these PHR-mediated PSR-specific mobile mRNAs are translated in donor tissues, but not in recipient tissues. Further, these mobile mRNAs harbored a more unfolded 5 ' UTR than nonmobile mRNAs, non-PSR-mobile mRNAs, and nitrogen starvation-response mobile mRNAs. The study reveals that these PSR-specific mobile mRNAs are transported to recipient tissues to carry out a function independently of their encoded protein.

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