数字农科院2.0

Dual inner filter effect-driven ultrasensitive LFIA via Au@Pd core-shell nanoparticles for furazolidone detection

文献类型： 外文期刊

作者： Jing Zhou;Yuanyuan Cheng;Runting Han;Weijie Gong;Lei Zhao;Leina Dou;Xinjie Wang;Ibrahim A. Darwish;Daohong Zhang

作者机构：

关键词： Colorimetric;Fluorescence;Food safety;Furazolidone;Internal filtration effect

期刊名称： Sensors and Actuators B: Chemical

ISSN： 0925-4005

年卷期： 2026 年 452 卷

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： Efficient and sensitive detection of the furazolidone metabolite 3-amino-2-oxazolidinone (AOZ) is critical due to its food safety risks. Conventional lateral flow immunoassays (LFIAs) are limited by narrow absorption bands of single-metal quenchers, restricting trace detection. Here, we report a dual-mode LFIA based on large Au@Pd core–shell nanoparticles (LAu@PdNPs) that combine the localized surface plasmon resonance (LSPR) of Au cores (λmax = 546 nm) with broadband UV–vis absorption of Pd shells (300–800 nm), achieving more than 90 % quenching efficiency for yellow aggregation-induced emission (AIE) dots (Ex/Em = 425/540 nm), enabled by the dual internal filtration effect (IFE). The platform integrates a colorimetric readout (CM-LFIA) for intuitive visualization and a fluorescence “turn-on” mode (FQ-LFIA) that enables quantitative signal amplification, achieving ultrasensitive detection of AOZ. Limits of detection reached 0.036 ng mL⁻¹ (CM) and 0.018 ng mL⁻¹ (FQ), corresponding to 3.1- and 6.3-fold improvements over conventional AuNPs-LFIA. Validation in shrimp and chicken sausage matrices yielded recoveries of 88.2–114.9 % (RSD < 5 %), demonstrating robustness against lipid and protein interference. This portable, laser-free platform enables on-site AOZ screening and offers a promising approach for food safety monitoring and clinical diagnostics.

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