数字农科院2.0

Association between intestinal microbiota and inflammatory bowel disease

文献类型： 外文期刊

作者： Zhang, Yunchang;Si, Xuemeng;Yang, Ling;Wang, Hui;Sun, Ye;Liu, Ning

作者机构：

关键词： dysbiosis;IBD model;intestinal microbiota;metabolites

期刊名称： ANIMAL MODELS AND EXPERIMENTAL MEDICINE

ISSN： 2096-5451

年卷期： 2022 年

页码：

收录情况： CSCD（2021-2022年度）

摘要： Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), has emerged as a global disease with high incidence, long duration, devastating clinical symptoms, and low curability (relapsing immune response and barrier function defects). Mounting studies have been performed to investigate its pathogenesis to provide an ever-expanding arsenal of therapeutic options, while the precise etiology of IBD is not completely understood yet. Recent advances in high-throughput sequencing methods and animal models have provided new insights into the association between intestinal microbiota and IBD. In general, dysbiosis characterized by an imbalanced microbiota has been widely recognized as a pathology of IBD. However, intestinal microbiota alterations represent the cause or result of IBD process remains unclear. Therefore, more evidences are needed to identify the precise role of intestinal microbiota in the pathogenesis of IBD. Herein, this review aims to outline the current knowledge of commonly used, chemically induced, and infectious mouse models, gut microbiota alteration and how it contributes to IBD, and dysregulated metabolite production links to IBD pathogenesis.

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