数字农科院2.0

The CCCH-tandem zinc-finger protein OsTZF1 1 positively regulates basal immunity but suppresses Piz-t-mediated blast resistance in rice

文献类型： 外文期刊

作者： 尤小满;;龙佳薇;;王如意;;侯昕一;;王极嵩;;黄璇达;;王敏;;徐晓;;何峰;;胡慧婷;;郝泽芸;;陶辉;;宁约瑟

关键词： Rice immunity

期刊名称： Plant Communications

ISSN： 2590-3462

年卷期： 2025 年

页码：

收录情况： SCIE（2025版） ; ; CSCD（2025-2026年度）

摘要： Plant Nucleotide-binding leucine-rich repeat (NLR) immune receptors play a critical role in plant defense, but the mechanisms regulating their expression remain incompletely understood. Here, we report that the rice CCCH-tandem zinc finger protein OsTZF1 interacts with both AvrPiz-t Interacting Protein 10 (APIP10) and the NLR protein Piz-t. OsTZF1 positively regulates rice immunity by enhancing the transcript levels of OsSGT1 and OsKS4 through binding to the AAAGC motif. However, in Piz-t-carrying plants, knockout of OsTZF1 results in increased Piz-t transcript and protein levels, resulting in enhanced resistance to virulent strains of Magnaporthe oryzae without a growth penalty. Furthermore, we demonstrate that OsTZF1 can directly bind to the AAAGC motif of Piz-t, thereby repressing its expression level. Thus, OsTZF1 functions as a dual regulator: it activating general defense genes while suppressing Piz-t-mediated resistance to virulent strains, balancing resistance and growth. These findings reveal a strategy to engineer NLR-mediated resistance in crops by fine-tuning immune regulators to achieve both disease resistance and yield stability.

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