数字农科院2.0

Molecular Evolution of Cu Transporters and Transcription Factors in Plant Response to Copper Stress

文献类型： 外文期刊

作者： Haiyang Tang;Qianqian Tang;Jin Zhang;Xuan Chen;Tao Tong;Qingfeng Zheng;Li Hao;Fenglin Deng;Guang Chen;Zhong Hua Chen;Fanrong Zeng;Yuan Qin;Wei Jiang

作者机构：

关键词： copper homeostasis;COPT;detoxification;plants;transcriptional regulation

期刊名称： Plants

ISSN： 2223-7747

年卷期： 2025 年 14 卷 17 期

页码：

收录情况： SCIE（2025版）

摘要： Copper (Cu) is an essential micronutrient for plants, playing a crucial role in various physiological and molecular processes. Excess Cu induces oxidative stress and disrupts cellular functions, while Cu deficiency causes chlorosis and poor pollen development, thereby reducing crop yields. However, the molecular and evolutionary mechanisms of Cu tolerance and homeostasis remain unclear in the plant kingdom. In this review, we discuss the uptake, transport, and detoxification of Cu through high-affinity Cu transporters (COPTs). Additionally, we update recent studies on maintaining Cu balance by mediating the root exudation of organic acids (e.g., citrate and proline), xylem/phloem loading, cell wall binding, vacuolar sequestration, redistribution, and the activity of antioxidant enzymes (e.g., SOD, CAT, and APX). Furthermore, tissue-specific expression analyses reveal that COPT genes exhibit distinct spatial regulation in the roots and leaves, which are the primary sites of Cu transport and detoxification. Overall, our review highlights the critical roles of COPT gene families and detoxification pathways in maintaining Cu homeostasis in plants. Future research should focus on genetic engineering approaches to enhance Cu tolerance, optimize Cu distribution in grains, and mitigate soil contamination risks. By clarifying these mechanisms, we can develop strategies to sustain crop production under increasing Cu stress, thereby ensuring food security and human health.

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