数字农科院2.0

Research advances on whole grains benefit on metabolic syndrome via gut homeostasis regulation

文献类型： 外文期刊

作者： Wang, Xinru;Liang, Hanying;Zhu, Hao;Wang, Yifang;Sun, Hongzhao;Liu, Lingyi;Xiao, Jianbo;Yan, Ning;Wang, Chuang;Liu, Lianliang

作者机构：

关键词： Gut microbiota;inflammation;intermediate metabolite;metabolic syndrome;whole grain

期刊名称： CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

ISSN： 1040-8398

年卷期： 2025 年

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： Whole grains are abundant in polyphenols, phytosterols, dietary fiber beta-glucan carotenoids, etc. They are highly bioavailable as intermediate metabolites processed by gut microbiota. These intermediate metabolites can enter the circulation from the gut, and then participate in the biochemical pathways that induce metabolic syndrome and improve the abnormal state of body. Metabolic syndrome is often accompanied by oxidative stress, carbonyl stress, inflammation and other abnormal states. Intermediate metabolites such as polyphenols can signal the brain. Then, under the control of the brain, it regulates the blood sugar level, blood lipid level, bile acid level, etc., and maintains the health. In this process, the brain-gut axis and liver-gut axis play a crucial part. In this review, the pathogenesis of type 2 diabetes (T2DM) mellitus, obesity, atherosclerosis and nonalcoholic liver syndrome and the role of brain-gut axis and liver-gut axis in the pathogenesis of metabolic syndrome were described in detail. The regulatory role of whole grains in these four metabolic syndromes was investigated. Dietary components have great potential for better utilization in the prevention and treatment of metabolic syndrome. The importance of a whole grain diet was explored and techniques for improving the bioavailability of functional components in whole grains were also investigated.

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