数字农科院2.0

Homoharringtonine is highly effective against SARS-CoV-2: a potential first-line defense in future coronavirus epidemics

文献类型： 外文期刊

作者： 文海军;;;;马华娟;;;;钟功勋;;;;丁傲;;;;王溪;;;; Xiao-Ju Lai;;;; Chang-Hao Shi;;;;Miles Tracy;;;;Si-Jin Wu;;;;Jia-Sheng Li;;;; Ge Zhang;;;;Yong-Bo Yao;;;; Wei Chen;;;; Xue-Yu Liu;;;; Zhi-Chao Xu;;;; Xue Cao;;;; Wen-Bin He;;;;Jing Feng;;;; Guo-Dong Wang;;;;Feng-Liang Liu;;;;Wei-Shun Zeng;;;;Guang-An Lu;;;;Jia-Yu Guo;;;;Yong-Tang Zheng;;;;Hui Zeng;;;;Xiong-Lei He;;;;Fu-Jie Zhang;;;; Zhi-Hong Hu;;;; Xue-Mei Lyu;;;;陈化兰;;;;Xin-Xing Lei;;;; Jian Li;;;; Man-Li Wang;;;;Qi-Chun Cai;;;;吴仲义

关键词： 高三尖杉酯碱;;冠状病毒;;SARS-CoV-2

期刊名称： National Science Review

ISSN： 2095-5138

年卷期： 2025 年

页码：

收录情况： SCIE（2025版） ; ; EI（2025版） ; ; CSCD（2025-2026年度） ; ; 科技核心（2024版）

摘要： 鉴于COVID-19是本世纪第三次冠状病毒疫情，为应对可能出现的第四次疫情，建立一套治疗方案显得尤为重要。本文提出一种可通过鼻喷大规模施用的方案，该方案基于已获批用于治疗其他疾病的高三尖杉酯碱（HHT），可在感染后2-4日内清除上呼吸道（病毒初始富集部位）的SARS-CoV-2病毒。实验表明，在纳摩尔浓度下，HHT能抑制蛋白合成延伸，并在体外有效抑制所有四种受试冠状病毒（包括SARS-CoV-2）的复制，显示出广谱抗冠状病毒潜力。在动物模型中，每日鼻腔滴注小剂量（40微克）HHT可在3日内清除所有受试小鼠体内的SARS-CoV-2。2022年12月，26名癌症患者通过雾化方式接受HHT治疗（每日1毫克），雾化后6小时上呼吸道病毒载量平均下降四分之三。在2023年5月的疫情波动期间，11名无其他基础疾病的患者通过重复液体鼻喷接受低日剂量（0.2毫克）HHT治疗，其中10人在2-4日内病毒被完全清除。同期中国大规模队列研究显示，多数患者需要7-9日才能转为阴性。两项临床试验中均未观察到任何不良反应。通过对已获批COVID-19治疗药物的简要比较，可见HHT具有多重优势。随着持续研发，该方案有望成为未来冠状病毒疫情暴发时的一线防御手段。

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