数字农科院2.0

Repressor elements provide insights into tissue development and phenotypes in pigs

文献类型: 外文期刊

作者: Yue Dong Zhang;Chao Guo;Hang Liu;Yun Gao;Yongjun Tan;Longjian Niu;Ligang Wang;Lixian Wang;David M. Irwin;Chunhui Hou;Zhong Yin Zhou;Ya Ping Zhang

作者机构:

关键词: KLF4;Pig;Regulatory model;Repressor elements;Silencer;Super repressor elements;Tissue development

期刊名称: Zoological research

ISSN: 2095-8137

年卷期: 2024 年 45 卷 6 期

页码:

收录情况: SCIE(2024版) ; ; CSCD(2023-2024年度) ; ; 科技核心(2024版)

摘要: 抑制元件在猪的经济表型中发挥着重要的作用。然而,这些元件还未得到充分表征。在该研究中,我们使用来自三个胚层的六种组织的H3K27me3、ATAC-seq和RNA-seq数据,在猪基因组中鉴定出2 034个超级抑制元件 (SREs) 和22 223个典型抑制元件 (TREs)。在已确定的抑制元件中,许多是中胚层和外胚层组织共有的。SREs对靶基因的调控紧实(在特定的基因组区域内,SREs作用于少数靶基因,且效果较强),而TREs的调控较为松散(作用范围较广,但效果较弱)。此外,在神经组织中,在干细胞分化为前体细胞的阶段,抑制元件靶基因的表达开始受到抑制。最后,我们还发现许多调控元件通过相互配合 (加性效应) 来调控KLF4的表达。该研究第一次呈现了全面的家猪抑制元件图谱,为未来抑制元件的研究提供了重要参考。.

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