数字农科院2.0

Inhibition of caspase-1-dependent apoptosis suppresses peste des petits ruminants virus replication

文献类型： 外文期刊

作者： Li, Lingxia;Li, Shengqing;Han, Shengyi;Li, Pengfei;Du, Guoyu;Wu, Jinyan;Cao, Xiaoan;Shang, Youjun

作者机构：

关键词： Peste-des-petits-ruminants virus;mononuclear;innate immunity;inflammation;interaction

期刊名称： JOURNAL OF VETERINARY SCIENCE

ISSN： 1229-845X

年卷期： 2023 年

页码：

收录情况： SCIE（2023版）

摘要： Background: Peste des petits ruminants (PPR), caused by the PPR virus (PPRV), is an acute and fatal contagious disease that mainly infects goats, sheep, and other artiodactyls. Peripheral blood mononuclear cells (PBMCs) are considered the primary innate immune cells.Objectives: PBMCs derived from goats were infected with PPRV and analyzed to detect the relationship between PPRV replication and apoptosis or the inflammatory response.Methods: Quantitative real-time polymerase chain reaction was used to identify PPRV replication and cytokines expression. Flow cytometry was conducted to detect apoptosis and the differentiation of CD4+ and CD8+ T cells after PPRV infection.Results: PPRV stimulated the differentiation of CD4+ and CD8+ T cells. In addition, PPRV induced apoptosis in goat PBMCs. Furthermore, apoptosis and the inflammatory response induced by PPRV could be suppressed by Z-VAD-FMK and Z-YVAD-FMK, respectively. Moreover, the virus titer of PPRV was attenuated by inhibiting caspase-1-dependent apoptosis and inflammation.Conclusions: This study showed that apoptosis and the inflammatory response play an essential role in PPR viral replication in vitro, providing a new mechanism related to the cell host response.

分类号：

  • 相关文献

[1]抗病毒免疫因子Viperin的研究进展ProgressinStudiesofViperin;anImportantCellularAntiviralFactor. 朱春辉1,2,汤艳东2,徐方1,周建华2,3*ZHUChunhui1,2,TANGYandong2,XUFang1,ZHOUJianhua2,3*. 2015

[2]Development of a competitive ELISA using monoclonal antibodies for detecting neutralizing antibodies against Peste-des-petits-ruminants virus. Linjie Hu,Haoyue Xu,Xueliang Zhu,Hongjiao Peng,Ruixue Deng,Yuefeng Sun,Xuelian Meng. 2025

[3]Newcastle disease virus-like particles induce DC maturation through TLR4/NF-kappa B pathway and facilitate DC migration by CCR7-CCL19/CCL21 axis. Qian, Jing,Xu, Xiaohong,Ding, Jiaxin,Yin, Renfu,Xue, Cong,Cong, Yanlong,Ding, Zhuang,Sun, Yixue,Wang, Jianzhong,Wang, Chunfeng,Ding, Chan,Yu, Shengqing,Liu, Xiufan,Hu, Shunlin.

[4]Transcript Profiling of Toll-Like Receptor mRNAs in Selected Tissues of Mink (Neovison vison). Tong, Mingwei,Yi, Li,Cheng, Yuening,Zhang, Miao,Cao, Zhigang,Wang, Jianke,Zhao, Hang,Lin, Peng,Cheng, Shipeng,Yang, Yong.

[5]Two myeloid differentiation factor 88 (MyD88) isoforms identified in ducks. Cheng, Yuqiang,Wang, Hengan,Yan, Yaxian,Sun, Jianhe,Ding, Chan.

[6]Molecular cloning and functional characterization of a novel isoform of chicken myeloid differentiation factor 88 (MyD88). Qiu, Yafeng,Shen, Yang,Li, Xiangdong,Ding, Chan,Ma, Zhiyong.

[7]A secreted cystatin from the tick Haemaphysalis longicornis and its distinct expression patterns in relation to innate immunity. Zhou, Jinlin,Ueda, Mami,Umemiya, Rika,Battsetseg, Badgar,Boldbaatar, Damdinsuren,Xuan, Xuenan,Fujisaki, Kozo.

[8]Icariin induces the expression of toll-like receptor 9 in Ana-1 murine macrophages. Li, Li,Miao, Jianhua,Xu, Yongli,Peng, Lina,Qiu, Yafeng,Gao, Xiaoqi,Shi, Zixue,Shao, Donghua,Ma, Zhiyong,Zhou, Ying.

[9]Molecular cloning of Peking duck Toll-like receptor 3 (duTLR3) gene and its responses to reovirus infection. Song, Kaijie,Li, Chuanfeng,Chen, Zongyan,Ding, Chan,Liu, Guangqing,Zhang, Miaotao,Song, Kaijie. 2015

[10]Regulatory effects of dietary L-Arg supplementation on the innate immunity and antioxidant ability in broiler chickens. Hu Ya-di,Tan Jian-zhuang,Qi Ji,Zhang Hong-fu. 2016

[11]Goose RIG-I functions in innate immunity against Newcastle disease virus infections. Sun, Yingjie,Ding, Na,Yu, Shengqing,Meng, Chunhun,Chen, Hongjun,Qiu, Xusheng,Zhang, Shilei,Yu, Yang,Zhan, Yuan,Ding, Chan,Ding, Siyu Serena.

[12]Glycyrrhetinic acid extracted from Glycyrrhiza uralensis Fisch induces the expression of Toll-like receptor 4 in Ana-1 murine macrophages. Li, Li,Miao, Jian-Hua,Xu, Yong-Li,Peng, Li-Na,Qiu, Ya-Feng,Gao, Xiao-Qi,Shi, Zi-Xue,Shao, Dong-Hua,Wei, Jian-Chao,Ma, Zhi-Yong,Zhou, Ying. 2011

[13]Differential and spatial regulation of the prophenoloxidase (proPO) and proPO-activating enzyme in cuticular melanization and innate immunity in Bombyx mori pupae. Zou, Feng Ming,Lee, Kwang Sik,Kim, Bo Yeon,Jin, Byung Rae,Zou, Feng Ming,Kim, Hong Ja,Gui, Zhong Zheng,Zhang, Guo Zheng,Guo, Xijie. 2015

[14]Peptidoglycan Recognition Protein S2 From Silkworm Integument: Characterization, Microbe-Induced Expression, and Involvement in the Immune-Deficiency Pathway. Yang, Jie,Wang, Xiaonan,Wu, Jinmei,Tang, Shunming,Shen, Zhongyuan,Wu, Jinmei. 2015

[15]Recent Progress in Understanding PAMP- and Effector-Triggered Immunity against the Rice Blast Fungus Magnaporthe oryzae. Liu, Jinling,Ning, Yuese,Ding, Bo,Wang, Xuli,Wang, Guo-Liang,Liu, Jinling,Wang, Zhilong,Liu, Jinling,Wang, Zhilong,Wang, Guo-Liang. 2013

[16]The VP3 structural protein of foot-and-mouth disease virus inhibits the IFN-beta signaling pathway. Li, Dan,Yang, Wenping,Yang, Fan,Liu, Huanan,Zhu, Zixiang,Lian, Kaiqi,Liu, Xiangtao,Zheng, Haixue,Lei, Caoqi,Li, Shu,Shu, Hongbing.

[17]The role of effectors and host immunity in plant-necrotrophic fungal interactions. Jiang, Nan,Liu, Wende,Wang, Guo-Liang,Jiang, Nan,Liu, Jinling,Jiang, Nan,Liu, Jinling,Wang, Guo-Liang.

[18]The Tug-Of-War Between Plants And V.iruses: Great Progress And M any Remaining Questions. Cheng, Xiaofei,Zhou, Xueping,Zhou, Xueping,Wu, Xiaoyun,Valli, Adrian,Antonio Garcia, Juan. 2019

[19]The Innate Immunity Of Guinea P.igs Against Highly Pathogenic A vian Influenza Virus Infection. Zhang, K, Xu, WW, Zhang, ZW, Liu, J, Li, J, Sun, LJ, Sun, WY, Jiao, PR, Sang, XY, Ren, ZG, Yu, ZJ, Li, YG, Feng, N, Wang, TC, Wang, HL, Yang, ST, Zhao, YK, Zhang, XM, Wilker, PR, Liu, WJ, Liao, M, Chen, HL, Gao, YW, Xia, XZ. 2017

[20]Innate Sensing Of Influenza A V.irus Hemagglutinin Glycoproteins By T he Host Endoplasmic Reticulum (Er) Stress Pathway Triggers A Potent Antiviral Response Via Er-Associated Protein Degradation. Frabutt, DA, Bin Wang, B, Riaz, S, Schwartz, RC, Zheng, YH. 2018

作者其他论文 更多>>