数字农科院2.0

Multi-omics study reveals a light-dependent regulatory network of flavonoid biosynthesis in lettuce (Lactuca sativa L.)

文献类型： 外文期刊

作者： Xiang, Yuting;Zheng, Shuxin;Wang, Hsihua;Chen, Bang;Fu, Rao;Huang, Tao;Zhang, Li;Song, Bo;Li, Yuejian;Yang, Qichang;Yang, Xiao;Zhang, Yang

作者机构：

关键词： lettuce;metabolome;transcriptome;flavonoids;LsBBX20;LsMYB114;LsMYB114-like

期刊名称： SCIENCE CHINA-LIFE SCIENCES

ISSN： 1674-7305

年卷期： 2025 年

页码：

收录情况： SCIE（2025版） ; ; CSCD（2025-2026年度） ; ; 科技核心（2024版）

摘要： Although lettuce (Lactuca sativa L.) is known for its high flavonoid content, the regulatory mechanisms of flavonoid biosynthesis are yet to be fully investigated. A metabolic network profile was constructed based on metabolomic and transcriptomic datasets derived from five lettuce growth stages. From this analysis, we identified 201 metabolites and 15,775 co-expressed genes, which were subsequently organized into six distinct expression modules. A novel flavonoid biosynthesis regulatory network emerged, comprising the transcription factors LsBBX20, LsMYB114, and LsMYB114-like. Each of these three factors was found to individually regulate the expression of flavonoid biosynthesis genes. LsBBX20 further regulates the expression of LsMYB114 and LsMYB114-like in a light-dependent manner. The results of this study include not only a novel regulatory network of flavonoid biosynthesis but also a valuable dataset for the systematic investigation of metabolic regulation in lettuce.

分类号：

  • 相关文献

[1]Integrated transcriptomic and metabolomic analysis provides insights into cold tolerance in lettuce (Lactuca sativa L.). Xiao Yang,Yingying Han,Guotao Huo,Guojun Ge,Shuping He,Xiao Yang,Li Zhang,Shiwei Wei,Lijun Luo. 2024

[2]Comparative transcriptomics and metabolomics analyses provide insights into thermal resistance in lettuce (Lactuca sativa L.). Shiwei Wei,Li Zhang,Guotao Huo,Guojun Ge,Lijun Luo,Qichang Yang,Xiao Yang,Ping Long. 2021

[3]Integrated metabolomics and transcriptomics insights on flavonoid biosynthesis of a medicinal functional forage, Agriophyllum squarrosum (L.), based on a common garden trial covering six ecotypes. Tingzhou Fang,Shanshan Zhou,Chaoju Qian,Xia Yan,Xiaoyue Yin,Xingke Fan,Pengshu Zhao,Yuqiu Liao,Liang Shi,Yuxiao Chang,Xiao Fei Ma. 2022

[4]Combining quantitative trait locus mapping with multiomics profiling reveals genetic control of corn leaf aphid (Rhopalosiphum maidis) resistance in maize. Wang, Tengyue,Wang, Kaiji,Wang, Chuanhong,Zhao, Yibing,Tao, Zhen,Li, Junyao,Wang, Lei,Shi, Jian,Huang, Shijie,Xie, Chuanxiao,Li, Peijin. 2023

[5]Interactive effects of light quality and nitrate supply on growth and metabolic processes in two lettuce cultivars (Lactuca sativa L.). Ying Liang,Yating Dong,Qichang Yang,Daisuke Urano,Zheng Wang. 2023

[6]Integrated metabolomic and transcriptomic analysis revealed the transition of functional components in edible flower buds of Hemerocallis citrina Baroni. Congrong Jiang,Wenwen Zhang,Yating Zhang,Guanghui Yang,Dongmei Cao,Wei Li. 2024

[7]Cellobiose elicits immunity in lettuce conferring resistance to Botrytis cinerea. He, Jiuxing,Kong, Meng,Qian, Yuanchao,Gong, Min,Lv, Guohua,Song, Jiqing. 2022

[8]Multi-omics integration to explore the molecular insight into the volatile organic compounds in watermelon. Chengsheng Gong,Nan He,Hongju Zhu,Muhammad Anees,Xuqiang Lu,Wenge Liu. 2023

[9]Defensive Resistance of Cowpea Vigna unguiculata Control Megalurothrips usitatus Mediated by Jasmonic Acid or Insect Damage. Tao Li,Mingyue Feng,Yuanming Chi,Xing Shi,Zilin Sun,Zhen Wu,Aomei Li,Wangpeng Shi. 2023

[10]Transcriptomic and metabolomic analyses reveal that exogenous strigolactones alleviate the response of melon root to cadmium stress. Chen X.,Shi X.,Ai Q.,Han J.,Wang H.,Fu Q.. 2022

[11]Transcriptome Co-expression Network and Metabolome Analysis Identifies Key Genes and Regulators of Proanthocyanidins Biosynthesis in Brown Cotton. Zhenzhen Wang,Xiaomeng Zhang,Shoupu He,Abdul Rehman,Yinhua Jia,Hongge Li,Zhaoe Pan,Xiaoli Geng,Qiong Gao,Liru Wang,Zhen Peng,Xiongming Du. 2022

[12]Transcriptomic and Metabolomic Analysis of Wheat Kernels in Response to the Feeding of Orange Wheat Blossom Midges (Sitodiplosis mosellana) in the Field. Qian Wang,Xiaobei Liu,Huan Liu,Yu Fu,Yumeng Cheng,Lijiao Zhang,Wangpeng Shi,Yong Zhang,Julian Chen. 2022

[13]Integrated Transcriptome and Metabolome Dissecting Interaction between Vitis vinifera L. and Grapevine Fabavirus. Baodong Zhang,Mengyan Zhang,Xiaojun Jia,Guojun Hu,Fang Ren,Xudong Fan,Yafeng Dong. 2023

[14]Integrated Metabolome and Transcriptome Analysis Unveils the Underlying Molecular Response of Panax ginseng Plants to the Phytophthora cactorum Infection. Hong Kan,Shuai Qu,Kai Dong,Shihan Wang,Chen Xu,Yingping Wang,Shuang Hua. 2023

[15]Multi-omics analyses of 398 foxtail millet accessions reveal genomic regions associated with domestication, metabolite traits, and anti-inflammatory effects. Xukai Li,Jianhua Gao,Jingyi Song,Kai Guo,Siyu Hou,Xingchun Wang,Qiang He,Yanyan Zhang,Yakun Zhang,Yulu Yang,Jiaoyan Tang,Hailang Wang,Staffan Persson,Mingquan Huang,Lishuai Xu,Linlin Zhong,Dongqin Li,Yongming Liu,Hua Wu,Xianmin Diao,Pe. 2022

[16]Integrative analysis of metabolome and genome-wide transcriptome reveal the flavor changes in apple (Malus pumila Mill) after the novel acaricide cyflumetofen application. Minmin Li,Lin Li,Zhiqiang Kong,Noel Gregoire,Rui Quan,Zisheng Luo,Xingyu Lin,Jesus Simal-Gandara,Bei Fan,Fengzhong Wang. 2023

[17]Comparison of transcriptome and metabolome analysis revealed differences in cold resistant metabolic pathways in different apple cultivars under low temperature stress. Xu, Gongxun,Li, Lijie,Zhou, Jia,Lyu, Deguo,Zhao, Deying,Qin, Sijun. 2023

[18]Editorial: Omics data-based identification of plant specialized metabolic genes. Peipei Wang,Pengxiang Fan,Yan Bao,Wei Li,Li Wang. 2023

[19]Metabolome and Transcriptome Analyses Reveal the Differences in the Molecular Mechanisms of Oat Leaves Responding to Salt and Alkali Stress Conditions. Bai, Jianhui,Lu, Peina,Li, Feng,Li, Lijun,Yin, Qiang. 2023

[20]Metabolome and Transcriptome Integration Reveals Insights Into Flavor Formation of ‘Crimson’ Watermelon Flesh During Fruit Development. Chengsheng Gong,Weinan Diao,Hongju Zhu,Muhammad Jawad Umer,Shengjie Zhao,Nan He,Xuqiang Lu,Pingli Yuan,Muhammad Anees,Dongdong Yang,M. O. Kaseb,Wenge Liu. 2021

作者其他论文 更多>>