数字农科院2.0

Vimentin Dynamics in Viral Infection: Shield or Sabotage?

文献类型： 外文期刊

作者： Ling, Ying;Ling, Xuanyi;Liu, Zaixin

作者机构：

关键词： vimentin;virus;co-receptor;PTMs;vimentin cage;viral replication complexes

期刊名称： INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ISSN： 1661-6596

年卷期： 2025 年 27 卷 1 期

页码：

收录情况： SCIE（2025版）

摘要： Vimentin is a type III intermediate filament protein that maintains cellular integrity, organelle positioning, and resilience to mechanical stress, but it is increasingly recognized for its dynamic change in viral infection. Viral infection causes vimentin filament disassembly into soluble oligomers with hydrophobic and acidic interfaces conducive to viral binding. These oligomers are recruited to the cell surface, where they act as viral co-receptors, facilitating viral attachment and entry. Upon entry, the viral protein induces post-translational modifications in intracellular vimentin filaments undergoing rearrangement processes, including disassembly into oligomers and then reassembly into cage-like structures that encapsulate viral replication complexes. Whether these structures promote viral replication or represent a host-imposed defense remains open. Our findings highlight the pro-viral shield and anti-viral sabotage role, a context-dependent role of vimentin during viral infection. Importantly, we offer a perspective encompassing structural biology and molecular and cellular signaling insights into vimentin dynamics, an approach that has not been explored in the current literature. We further propose that targeting vimentin is an innovative strategy for anti-viral intervention.

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