数字农科院2.0

Nano-La2O3 undermines honeybee cognition by invading the brain and accelerating neuronal apoptosis

文献类型： 外文期刊

作者： Feng, Wangjiang;Ge, Yuan;Holden, Patricia A.;Zhang, Yongxiang;Dai, Pingli;Liu, Yong-Jun

作者机构：

期刊名称： ENVIRONMENTAL SCIENCE-NANO

ISSN： 2051-8153

年卷期： 2025 年

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： The widespread application of nanoparticles in agriculture poses threats to pollinators like honeybees, but the mechanisms of nanoparticle effects on honeybee cognitive behaviours remain poorly understood. To begin to address this knowledge gap, we examined the cognitive and physiological implications of lanthanum oxide nanoparticles (nano-La2O3) on honeybees (Apis mellifera L.). Our findings revealed that exposure to nano-La2O3 (e.g., >10 mg L-1) significantly impaired olfactory associative learning and memory of honeybees (p < 0.05) in a dose-dependent fashion, attributable to the increased apoptosis of neural cells and the downregulation of genes related to cognitive functions (cAMP-dependent protein kinase (pka), cAMP-responsive element binding protein (creb), n-methyl-D-aspartate receptor 1 (nmdar1)) due to the invasion of nano-La2O3 into brains. This further led to decreased sucrose consumption and reduced survival rates among exposed honeybees. Our research documents the first evidence of nano-La2O3 accumulation in honeybee brains and provides insights into the mechanisms through which nanoparticles negatively affect the cognitive behaviour of honeybees, highlighting new potential ecological risks posed by nanomaterials.

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