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Ginger and 6-gingerol prevent lipopolysaccharide-induced intestinal barrier damage and liver injury in mice

文献类型: 外文期刊

作者: Guo X.-X.; Zhang Y.-D.; Wang T.-C.; Wang X.-L.; Xu Y.-Y.; Wang Y.; Qiu J.

作者机构:

关键词: antiinflammatory agent; catechol derivative; fatty alcohol; ginger extract; gingerol; lipopolysaccharide; plant extract; animal; apoptosis; chemistry; drug effect; enteropathy; ginger; human; immunology; injury; Institute for Cancer Research mouse; intestine mucosa; liver; liver disease; male; mouse; pathophysiology; Animals; Anti-Inflammatory Agents; Apoptosis; Catechols; Fatty Alcohols; Ginger; Humans; Intestinal Diseases; Intestinal Mucosa; Lipopolysaccharides; Liver; Liver Diseases; Male; Mice; Mice; Inbred ICR; Plant Extracts

期刊名称: Journal of the Science of Food and Agriculture

ISSN: 0022-5142

年卷期: 2022 年 102 卷 3 期

页码:

收录情况: SCIE(2022版)

摘要: BACKGROUND: Inflammation-related diseases present a significant public health problem. Ginger is a flavoring spice and medicinal herb with anti-inflammatory activity. This study investigated the preventive effects of ginger extract (GE) and its main bioactive component, 6-gingerol (6G), on lipopolysaccharide (LPS)-induced intestinal barrier dysfunction and liver injury in mice. RESULTS: GE and 6G were orally administered to mice for seven consecutive days before LPS administration. After 24 h, the mice were sacrificed. GE and 6G were found to significantly reverse LPS-induced inflammation in the mouse ileum by modifying the NF-κB pathway. They also alleviated apoptosis in the ileum by downregulating Bax and cytochrome c gene expression and by inhibiting the caspase-3 pathway. Through the aforementioned mechanisms, GE and 6G restored the intestinal barrier by increasing ZO-1 and claudin-1 protein expressions. Gut-derived LPS induced inflammation and apoptosis in the liver; these effects were markedly reversed through GE and 6G treatment. 6G was the most abundant component in GE, as evidenced through liquid chromatography–mass spectrometry, and accounted for >50% of total gingerols and shogaols in GE. CONCLUSION: The current results support the use of GE and 6G as dietary supplements to protect against gut-derived endotoxemia-associated inflammatory response and disorders. © 2021 Society of Chemical Industry. © 2021 Society of Chemical Industry.

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