数字农科院2.0

Mitofusins: from mitochondria to fertility

文献类型： 外文期刊

作者： Zhao, Shanjiang;Heng, Nuo;Wang, Huan;Wang, Haoyu;Zhang, Haobo;Gong, Jianfei;Hu, Zhihui;Zhu, Huabin

作者机构：

关键词： Mitofusin;Mitochondria;Fertility;Germ cell formation;Embryonic development;Reproductive diseases

期刊名称： CELLULAR AND MOLECULAR LIFE SCIENCES

ISSN： 1420-682X

年卷期： 2022 年 79.0 卷 7 期

页码：

收录情况： SCIE（2022版）

摘要： Germ cell formation and embryonic development require ATP synthesized by mitochondria. The dynamic system of the mitochondria, and in particular, the fusion of mitochondria, are essential for the generation of energy. Mitofusin1 and mitofusin2, the homologues of Fuzzy onions in yeast and Drosophila, are critical regulators of mitochondrial fusion in mammalian cells. Since their discovery mitofusins (Mfns) have been the source of significant interest as key influencers of mitochondrial dynamics, including membrane fusion, mitochondrial distribution, and the interaction with other organelles. Emerging evidence has revealed significant insight into the role of Mfns in germ cell formation and embryonic development, as well as the high incidence of reproductive diseases such as asthenospermia, polycystic ovary syndrome, and gestational diabetes mellitus. Here, we describe the key mechanisms of Mfns in mitochondrial dynamics, focusing particularly on the role of Mfns in the regulation of mammalian fertility, including spermatogenesis, oocyte maturation, and embryonic development. We also highlight the role of Mfns in certain diseases associated with the reproductive system and their potential as therapeutic targets.

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