数字农科院2.0

Comparative Analysis of Immune Responses in Pigs to High and Low Pathogenic Porcine Reproductive and Respiratory Syndrome Viruses Isolated in China

文献类型: 外文期刊

作者: Han, Z.;Liu, Y.;Wang, G.;He, Y.;Hu, S.;Li, Y.;Shi, W.;Wu, J.;Wang, S.;Liu, H.;Cai, X.

作者机构:

关键词: highly pathogenic porcine reproductive and respiratory syndrome virus;porcine reproductive and respiratory syndrome virus;cytokines;immunity modulation

期刊名称: TRANSBOUNDARY AND EMERGING DISEASES

ISSN: 1865-1674

年卷期: 2015 年 62 卷 5 期

页码:

收录情况: SCI

摘要: The CH-1a and HuN4 strains of porcine reproductive and respiratory syndrome virus (PRRSV) show different pathogenicities in pigs. To understand host immune responses against these viruses, we investigated the dynamic changes in cytokine levels produced in peripheral blood of piglets infected with the highly pathogenic PRRSV HuN4 strain or the CH-1a strain. Clinical signs, virus loads and serum cytokine levels [interferon(IFN)-, Interleukin (IL)-1, TNF-, IL-6, IL-12, IFN-, IL-10 and TGF-] were tested. The results showed that while piglets developed effective cellular immune responses against CH-1a infection, those infected with HuN4 displayed ineffective cellular immunity, organ lesions and persistent elevated levels of immunoregulatory cytokines (IL-10 and TGF-), which delayed the development of PRRSV-specific immune responses. These results demonstrated that HuN4 infection induced higher cytokine levels than that of CH-1a infection induced. The changes in inflammatory cytokines intensified the inflammatory reaction and damaged the tissues and organs.

分类号:

  • 相关文献

[1]Synergistic effects of sequential infection with highly pathogenic porcine reproductive and respiratory syndrome virus and porcine circovirus type 2. Fan, Peihu,Wei, Yanwu,Guo, Longjun,Wu, Hongli,Huang, Liping,Liu, Jianbo,Liu, Changming. 2013

[2]Evaluation of the Pathogenicity of a Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Variant in Piglets. Wei Tian-chao,Tian Zhi-jun,An Tong-qing,Jiang Yi-feng,Xiao Yan,Hu Shou-ping,Peng Jin-mei,Hao Xiao-fang,Zhang Shan-rui,Tong Guang-zhi,Zhou Yan-jun,Tong Guang-zhi,Wei Tian-chao. 2011

[3]Role of non-structural protein 2 in the regulation of the replication of the porcine reproductive and respiratory syndrome virus in MARC-145 cells: Effect of gene silencing and over expression. Wang, Feng-Xue,Wen, Yong-Jun,Yang, Bo-Chao,Liu, Zhun,Shi, Xin Chuan,Leng, Xue,Song, Ni,Wu, Hua,Chen, Li-Zhi,Cheng, Shi-Peng.

[4]Highly pathogenic porcine reproductive and respiratory syndrome virus GP5 B antigenic region is not a neutralizing antigenic region. Leng, Chao-Liang,An, Tong-Qing,Chen, Jia-Zeng,Gong, Da-Qing,Peng, Jin-Mei,Yang, Yong-Qian,Wu, Jiang,Guo, Juan-Juan,Li, Deng-Yun,Zhang, Yi,Meng, Zhen-Xiang,Wu, Yu-Quan,Tian, Zhi-Jun,Tong, Guang-Zhi,Tong, Guang-Zhi.

[5]Genomic Sequence And Virulence Of A. Novel Nadc30-Like Porcine R eproductive And Respiratory Syndrome Virus Isolate From The Hebei Province Of China. Sui, XK, Guo, XY, Jia, H, Wang, XX, Lin, WD, Li, M, Gao, XT, Wu, J, Jiang, YT, Willems, L, Zhu, HF, Xin, T, Hou, SH. 2018

[6]Proteomic analysis of Fasciola hepatica excretory and secretory products (FhESPs) involved in interacting with host PBMCs and cytokines by shotgun LC-MS/MS. Liu, Qing,Huang, Si-Yang,Yue, Dong-Mei,Wang, Jin-Lei,Zhu, Xing-Quan,Liu, Qing,Wang, Yujian,Li, Xiangrui,Huang, Si-Yang,Zhu, Xing-Quan.

[7]The pathogenic and vaccine strains of equine infectious anemia virus differentially induce cytokine and chemokine expression and apoptosis in macrophages. Lin, Yue-Zhi,Cao, Xue-Zhi,Li, Liang,Li, Li,Jiang, Cheng-Gang,Wang, Xue-Feng,Ma, Jian,Zhou, Jian-Hua. 2011

[8]Transcriptomic analysis of global changes in cytokine expression in mouse spleens following acute Toxoplasma gondii infection. He, Jun-Jun,Ma, Jun,Song, Hui-Qun,Zhou, Dong-Hui,Wang, Jin-Lei,Huang, Si-Yang,Zhu, Xing-Quan,Ma, Jun,Zhu, Xing-Quan.

[9]Cordyceps militaris polysaccharides can improve the immune efficacy of Newcastle disease vaccine in chicken. Wang, Mi,Qin, Tao,Hu, Yuanliang,Wang, Mi,Meng, Xinyu,Yang, Ruile,Li, Ying,Zhang, Lifang,Fei, Chengzhong,Zhen, Wenli,Zhang, Keyu,Wang, Xiaoyang,Xue, Feiqun.

[10]Effects of Enterococcus faecium (SF68) on immune function in mice. Sun, Peng,Wang, Jiaqi,Jiang, Yanmei,Sun, Peng.

[11]Study on immunological examination in Blood with two Streptococcus suis serotype 2 strains Infection in Miniture Swine Model. Cui, Li,Shen, Yan,Yuan, Cong-li,Cai, Xue-hui. 2009

[12]Evaluating the immune responses of mice to subcutaneous immunization with Helicobacter pylori urease B subunit. Sun, Peng,Wang, Jia-Qi,Zhang, Yu-Tao,Zhao, Sheng-Guo.

[13]Sulfated glucan can improve the immune efficacy of Newcastle disease vaccine in chicken. Wang, Mi,Yang, Ruile,Zhang, Lifang,Meng, Xinyu,Fei, Chenzhong,Zhang, Keyu,Wang, Xiaoyang,Zheng, Wenli,Xiao, Sui,Zhang, Saiqi,Xue, Feiqun,Wang, Mi,Hu, Yuanliang.

[14]Effects of aluminum trichloride on the trace elements and cytokines in the spleen of rats. Zhu, Yanzhu,Li, Yanfei,Zhu, Yanzhu,Miao, Liguang,Li, Xinwei,Chen, Chongxiao,Wang, Fan,Li, Jing,Hu, Chongwei. 2012

[15]Identification and molecular characterization of an Akirin2 homolog in Chinese loach (Paramisgurnus dabryanus). Xue, Xianli,Chen, Yeyu,Zhang, Xinshang,Luo, Huiying,Li, Zhongyuan,Zhao, Heng,Yao, Bin,Wang, Liwen.

[16]Infection of Goose with Genotype VIId Newcastle Disease Virus of Goose Origin Elicits Strong Immune Responses at Early Stage. Xu, Qianqian,Chen, Yuqiu,Zhao, Wenjun,Zhang, Tingting,Liu, Chenggang,Qi, Tianming,Ma, Deying,Xu, Qianqian,Chen, Yuqiu,Zhao, Wenjun,Zhang, Tingting,Liu, Chenggang,Qi, Tianming,Han, Zongxi,Shao, Yuhao,Liu, Shengwang. 2016

[17]Anti-idiotypic antibodies reduce efficacy of the attenuated vaccine against highly pathogenic PRRSV challenge. Yu, Ying,Kong, Ning,Zhang, Chong,Mu, Yang,Xiao, Shuqi,Zhao, Qin,Wang, Chengbao,Zhang, Gaiping,Zhou, En-Min,Yu, Ying,Cai, Xuehui,Wang, Gang,Liu, Yonggang,Xiao, Yihong,Zhang, Gaiping,Hiscox, Julian A.. 2014

[18]Parapoxvirus orf virus infection induces an increase in interleukin-8, tumour necrosis factor-alpha, and decorin in goat skin fibroblast cells. Wang, Lingling,Lu, Bingzhou,Zheng, Haixue,Zhang, Keshan,Liu, Xiangtao.

[19]Eimeria tenella: Expression profiling of toll-like receptors and associated cytokines in the cecum of infected day-old and three-week old SPF chickens. Cai, Jianping,Zhang, Lei,Liu, Renqiang,Ma, Liping,Wang, Yingwei,Pan, Baoliang,Wang, Ming. 2012

[20]Dietary microbial phytase exerts mixed effects on the gut health of tilapia: a possible reason for the null effect on growth promotion. Hu, Jun,Zhang, Xuezhen,Hu, Jun,Ran, Chao,He, Suxu,Cao, Yanan,Yao, Bin,Zhou, Zhigang,Ye, Yuantu.

作者其他论文 更多>>