数字农科院2.0

Mechanism of Ginsenoside Rg1 in Regulating the Metabolic Function of Intestinal Flora for the Treatment of High-Purine Dietary Hyperuricemia

文献类型： 外文期刊

作者： Sun, Qiang;Li, Zhiman;Yu, Yang;Sun, Yinshi

作者机构：

关键词： ginsenoside Rg(1);hyperuricemia;inflammatory factors;gut microbiota;short-chain fatty acid

期刊名称： NUTRIENTS

ISSN：

年卷期： 2025 年 17 卷 11 期

页码：

收录情况： SCIE（2025版）

摘要： Objective: Study the mechanism of ginsenoside Rg(1) in ameliorating hyperuricemia (HUA) induced by high-purine diet. Methods: Rats were randomly divided into groups, and the HUA model was established by administering a high-purine diet containing potassium oxonate combined with yeast. After the experiment, blood was collected via cardiac puncture, and the organ indices of the rats were calculated. Serum biochemical markers including aspartate aminotransferase (AST), alanine aminotransferase (ALT), triglyceride (TG), total cholesterol (TC), xanthine oxidase (XOD), creatinine (CREA), uric acid (UA), and blood urea nitrogen (BUN) were measured. Histopathological sections of the kidney and intestine were prepared. Western blot was used to assess the expression levels of intestinal occludin and zonula occludens-1 barrier proteins and key proteins in IL-17/NF-kappa B inflammatory pathways. After the experiment, fecal samples were collected from the rats. The gut microbiota of HUA-induced rats was analyzed via 16S rRNA sequencing, and the levels of short-chain fatty acids in the fecal samples were quantified using gas chromatography-mass spectrometry. Results: Ginsenoside Rg(1) significantly increased body weight and organ indexes as well as reduced serum levels of BUN, CREA, ALT, AST, XOD, and UA. Pathologic analysis showed that ginsenoside Rg(1) improved renal cell injury, glomerulosclerosis, and renal interstitial fibrosis while restoring intestinal barrier function. Ginsenoside Rg(1) down-regulated the expression of inflammatory proteins and up-regulated the levels of intestinal barrier proteins. The results of 16S rRNA sequencing showed that ginsenoside Rg(1) significantly increased the diversity index of gut microbiota and enhanced the number of beneficial bacteria in HUA rats. Short-chain fatty acids analysis demonstrated that ginsenoside Rg(1) markedly elevated the levels of acetate, propionate, butyrate, and valerate in HUA rats. Conclusions: Ginsenoside Rg(1) ameliorates and treats HUA by improving the composition of intestinal flora and inhibiting the IL-17/NF-kappa B signaling pathway to reduce inflammatory factors in the intestinal tract in HUA rats.

分类号：

  • 相关文献

[1]Dietary vitamin A modifies the gut microbiota and intestinal tissue transcriptome, impacting intestinal permeability and the release of inflammatory factors, thereby influencing Aβ pathology. Zhong Li Wang,Shao Jie Pang,Kai Wen Zhang,Peng Yu Li,Peng Gao Li,Chun Yang. 2024

[2]Short-chain fatty acids: key antiviral mediators of gut microbiota. Zhiqiang Xu,Tao Wang,Yanjin Wang,Yongfeng Li,Yuan Sun,Hua Ji Qiu. 2025

[3]The chemistry, processing, and preclinical anti-hyperuricemia potential of tea: a comprehensive review. Chen, Yu,Luo, Liyong,Hu, Shanshan,Gan, Renyou,Zeng, Liang. 2022

[4]High-Protein Diet Induces Hyperuricemia In A New Animal Model For Studying Human Gout. Hong, F, Zheng, AJ, Xu, PF, Wang, JL, Xue, TT, Dai, S, Pan, SJ, Guo, Y, Xie, XL, Li, LT, Qiao, XX, Liu, GH, Zhai, YG. 2020

[5]Uricolytic Bacillus from medicinal-edible plants ameliorates hyperuricemia in geese. Wei, Chao,Cao, Junxuan,Hu, Boyang,Du, Zetao,Zhang, Hongyu,Dai, Yujie,Peng, Ao,Liao, Yanyang,Zou, Zhaoxia,Xie, Chunliang,Chen, Jinjun. 2025

[6]Discriminative Gut Microbial Signatures in Hyperuricemia and Overweight Populations Revealed by Metagenomic Sequencing. Chen, Tianqi,Guo, Yang,Liang, Dong,Li, Da,Xing, Siyu,Li, Dan,Zhang, Chunhong,Wang, Fengzhong. 2025

[7]Effects of Immobilized Antimicrobial Peptides on Growth Performance, Serum Biochemical Index, Inflammatory Factors, Intestinal Morphology, and Microbial Community in Weaning Pigs. Liu N.,Ma X.,Jiang X.. 2022

[8]mmu-miR-374b-5p modulated inflammatory factors via downregulation of C/EBP β/NF-κB signaling in Kupffer cells during Echinococcus multilocularis infection. Guiting Pu,Yanping Li,Tingli Liu,Hong Li,Liqun Wang,Guoliang Chen,Shanling Cao,Hong Yin,Tharheer Oluwashola Amuda,Xiaola Guo,Xuenong Luo. 2024

[9]Evaluating the Impact of Arginine-to-Lysine Ratios on Growth Performance, Antioxidant Defense, and Immune Modulation in Juvenile Largemouth Bass (Micropterus salmoides). Yulong Sun,Shuailiang Zhang,Xueyao Luan,Tao Liu,Jiale He,Jiteng Wang,Tao Han. 2025

[10]Dietary organic acids ameliorate high stocking density stress-induced intestinal inflammation through the restoration of intestinal microbiota in broilers. Dong Dai,Guanghai Qi,Jing Wang,Haijun Zhang,Kai Qiu,Yanming Han,Yuanyuan Wu,Shugeng Wu. 2022

[11]Exposure to High Aerial Ammonia Causes Hindgut Dysbiotic Microbiota and Alterations of Microbiota-Derived Metabolites in Growing Pigs. Shanlong Tang,Ruqing Zhong,Chang Yin,Dan Su,Jingjing Xie,Liang Chen,Lei Liu,Hongfu Zhang. 2021

[12]Time-course alterations of gut microbiota and short-chain fatty acids after short-term lincomycin exposure in young swine. Shanlong Tang,Shunfen Zhang,Ruqing Zhong,Dan Su,Bing Xia,Lei Liu,Liang Chen,Hongfu Zhang. 2021

[13]Isotope-Coded Chemical Derivatization Method for Highly Accurately and Sensitively Quantifying Short-Chain Fatty Acids br. Feng, Xiaohui,Liu, Na,Yang, Youyou,Feng, Shengnan,Wang, Juan,Meng, Qingshi. 2022

[14]Effects of dietary supplementation with fermented flaxseed meal on the growth performance, immune function, and intestinal microbiota of growing pigs. Lei Xu,Zixi Wei,Yao Guo,Baozhu Guo,Long Cai,Jingjiao Yan,Lianghua Ma,Wenjuan Sun,Yanpin Li,Xianren Jiang,Xilong Li,Yu Pi. 2024

[15]Dietary crude protein time-dependently modulates the bacterial community and metabolites and changes dietary nutrient efficiency in growing pigs. Wang Y.,Zhou J.,Cao N.,Wang L.,Tu J.,Zeng X.,Qiao S.. 2024

[16]Short-chain fatty acid producers in compost tea as affected by brewing time and aeration condition. Wang, Xiaoxing,Wei, Qihang,Zhao, Quansheng,Liu, Xiayan,Deng, Hui,Li, Zhaojun. 2023

[17]Culturable autochthonous gut bacteria in Atlantic salmon (Salmo salar L.) fed diets with or without chitin. Characterization by 16S rRNA gene sequencing, ability to produce enzymes and in vitro growth inhibition of four fish pathogens. Askarian, Fatemeh,Sperstad, Sigmund,Ringo, Einar,Zhou, Zhigang,Olsen, Rolf Erik. 2012

[18]Use of chitin and krill in aquaculture - the effect on gut microbiota and the immune system: a review. Ringo, E.,Zhou, Z.,Olsen, R. E.,Song, S. K.. 2012

[19]Characterization of gut bacteria at different developmental stages of Asian honey bees, Apis cerana. Guo, Jun,Wu, Jie,Li, Jilian,Guo, Jun,Dai, Rongguo,Luo, Wenhua,Chen, Yanping,Evans, Jay D..

[20]Proteome changes in the intestinal mucosa of broiler (Gallus gallus) activated by probiotic Enterococcus faecium. Luo, Jianjie,Meng, Kun,Bai, Yingguo,Li, Ke,Yao, Bin,Zheng, Aijuan,Chang, Wenhuan,Cai, Huiyi,Liu, Guohua.

作者其他论文 更多>>