数字农科院2.0

Chemical structures, biosynthesis, bioactivities, and utilisation values for the diterpenes produced in tobacco trichomes

文献类型： 外文期刊

作者： Minglei Xu;Yongmei Du;Xiaodong Hou;Zhongfeng Zhang;Ning Yan

作者机构：

关键词： Bioactivities;Biosynthesis;Cembranoid diterpenes;Chemical structures;Labdane diterpenes;Nicotiana genus;Tobacco

期刊名称： Phytochemistry

ISSN： 0031-9422

年卷期： 2024 年 223 卷

页码：

收录情况： SCIE（2024版）

摘要： Cembranoids and labdanes are two important types of diterpenes in tobacco (Nicotiana genus) that are predominantly found in the leaf and flower glandular trichome secretions. This is the first systematic review of the biosynthesis, chemical structures, bioactivities, and utilisation values of cembranoid and labdane diterpenes in tobacco. A total of 131 natural cembranoid diterpenes have been reported in tobacco since 1962; these were summarised and classified according to their chemical structure characteristics as isopropyl cembranoids (1–88), seco-cembranoids (89–103), chain cembranoids (104–123), and polycyclic cembranoids (124–131). Forty natural labdane diterpenes reported since 1961 were also summarised and divided into epoxy side chain labdanes (132–150) and epoxy-free side chain labdanes (151–171). Tobacco cembranoid and labdane diterpenes are both formed via the methylerythritol 4-phosphate pathway and are synthesised from geranylgeranyl diphosphate. Their biosynthetic pathways and the four key enzymes (cembratrienol synthase, cytochrome P450 hydroxylase, copalyl diphosphate synthase, and Z-abienol cyclase) that affect their biosynthesis have been described in detail. A systematic summary of the bioactivity and utilisation values of the cembranoid and labdane diterpenes is also provided. The agricultural bioactivities associated with cembranoid and labdane diterpenes include antimicrobial and insecticidal activities as well as induced resistance, while the medical bioactivities include cytotoxic and neuroprotective activities. Further research into the cembranoid and labdane diterpenes will help to promote their development and utilisation as plant-derived pesticides and medicines.

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