数字农科院2.0

Plant-derived strategies to fight against severe acute respiratory syndrome coronavirus 2

文献类型： 外文期刊

作者： Li W.;Ding T.;Chang H.;Peng Y.;Li J.;Liang X.;Ma H.;Li F.;Ren M.;Wang W.

作者机构：

关键词： Antiviral drugs;Molecular farming;Plant natural products;SARS-CoV-2;Structural biology;Synthetic biology

期刊名称： European Journal of Medicinal Chemistry

ISSN： 0223-5234

年卷期： 2024 年 264 卷

页码：

收录情况： SCIE（2024版）

摘要： The coronavirus disease 2019 (COVID-19) pandemic has caused an unprecedented crisis, which has been exacerbated because specific drugs and treatments have not yet been developed. In the post-pandemic era, humans and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will remain in equilibrium for a long time. Therefore, we still need to be vigilant against mutated SARS-CoV-2 variants and other emerging human viruses. Plant-derived products are increasingly important in the fight against the pandemic, but a comprehensive review is lacking. This review describes plant-based strategies centered on key biological processes, such as SARS-CoV-2 transmission, entry, replication, and immune interference. We highlight the mechanisms and effects of these plant-derived products and their feasibility and limitations for the treatment and prevention of COVID-19. The development of emerging technologies is driving plants to become production platforms for various antiviral products, improving their medicinal potential. We believe that plant-based strategies will be an important part of the solutions for future pandemics. © 2023 Elsevier Masson SAS

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