Product of natural evolution (SARS, MERS, and SARS-CoV-2); deadly diseases, from SARS to SARS-CoV-2
文献类型: 外文期刊
作者: Mohamad Hesam Shahrajabian;Wenli Sun;Qi Cheng
作者机构:
关键词: coronaviruses; emerging diseases; MERS; pneumonia; SARS; SARS-CoV-2
期刊名称: Human Vaccines & Immunotherapeutics
ISSN: 2164-5515
年卷期: 2021 年 17 卷 1 期
页码:
收录情况: JCR(2021版)
摘要: SARS-CoV-2, the virus causing COVID-19, is a single-stranded RNA virus belonging to the order Nidovirales, family Coronaviridae, and subfamily Coronavirinae. SARS-CoV-2 entry to cellsis initiated by the binding of the viral spike protein (S) to its cellular receptor. The roles of S protein in receptor binding and membrane fusion makes it a prominent target for vaccine development. SARS-CoV-2 genome sequence analysis has shown that this virus belongs to the beta-coronavirus genus, which includes Bat SARS-like coronavirus, SARS-CoV and MERS-CoV. A vaccine should induce a balanced immune response to elicit protective immunity. In this review, we compare and contrast these three important CoV diseases and how they inform on vaccine development. © 2020 Taylor & Francis Group, LLC.
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