数字农科院2.0

Development of a MAGIC population and high-resolution quantitative trait mapping for nicotine content in tobacco

文献类型： 外文期刊

作者： Yuan G.;Sun K.;Yu W.;Jiang Z.;Jiang C.;Liu D.;Wen L.;Si H.;Wu F.;Meng H.;Cheng L.;Yang A.;Wang Y.

作者机构：

关键词： GWAS;MAGIC population;nicotine content;QTL;tobacco

期刊名称： Frontiers in Plant Science

ISSN： 1664-462X

年卷期： 2023 年 13 卷

页码：

收录情况： SCIE（2023版）

摘要： Multiparent Advanced Generation Inter-Cross (MAGIC) population is an ideal genetic and breeding material for quantitative trait locus (QTL) mapping and molecular breeding. In this study, a MAGIC population derived from eight tobacco parents was developed. Eight parents and 560 homozygous lines were genotyped by a 430K single-nucleotide polymorphism (SNP) chip assay and phenotyped for nicotine content under different conditions. Four QTLs associated with nicotine content were detected by genome-wide association mapping (GWAS), and one major QTL, named qNIC7-1, was mapped repeatedly under different conditions. Furthermore, by combining forward mapping, bioinformatics analysis and gene editing, we identified an ethylene response factor (ERF) transcription factor as a candidate gene underlying the major QTL qNIC7-1 for nicotine content in tobacco. A presence/absence variation (PAV) at qNIC7-1 confers changes in nicotine content. Overall, the large size of this MAGIC population, diverse genetic composition, balanced parental contributions and high levels of recombination all contribute to its value as a genetic and breeding resource. The application of the tobacco MAGIC population for QTL mapping and detecting rare allelic variation was demonstrated using nicotine content as a proof of principle. Copyright © 2023 Yuan, Sun, Yu, Jiang, Jiang, Liu, Wen, Si, Wu, Meng, Cheng, Yang and Wang.

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