数字农科院2.0

Whole-genome resequencing of Hu sheep identifies candidate genes associated with agronomic traits

文献类型： 外文期刊

作者： Zhao, Liming;Yuan, Lvfeng;Li, Fadi;Zhang, Xiaoxue;Tian, Huibin;Ma, Zongwu;Zhang, Deyin;Zhang, Yukun;Zhao, Yuan;Huang, Kai;Li, Xiaolong;Cheng, Jiangbo;Xu, Dan;Yang, Xiaobin;Han, Kunchao;Weng, Xiuxiu;Wang, Weimin

作者机构：

关键词： Hu sheep;Whole-genome resequencing;Selection signature;GPR35;NAV1;Single nucleotide polymorphism

期刊名称： JOURNAL OF GENETICS AND GENOMICS

ISSN： 1673-8527

年卷期： 2024 年 51 卷 8 期

页码：

收录情况： SCIE（2024版） ; ; CSCD（2023-2024年度） ; ; 科技核心（2024版）

摘要： The phenotypic diversity resulting from artificial or natural selection of sheep has made a significant contribution to human civilization. Hu sheep are a local sheep breed unique to China with high reproductive rates and rapid growth. Genomic selection signatures have been widely used to investigate the genetic mechanisms underlying phenotypic variation in livestock. Here, we conduct whole-genome sequencing of 207 Hu sheep and compare them with the wild ancestors of domestic sheep (Asiatic mouflon) to investigate the genetic characteristics and selection signatures of Hu sheep. Based on six signatures of selection approaches, we detect genomic regions containing genes related to reproduction (BMPR1B, BMP2, PGFS, CYP19, CAMK4, GGT5, and GNAQ), vision (ALDH1A2, SAG, and PDE6B), nervous system (NAV1), and immune response (GPR35, SH2B2, PIK3R3, and HRAS). Association analysis with a population of 1299 Hu sheep reveals that those missense mutations in the GPR35 (GPR35 g.952651 A>G; GPR35 g.952496 C>T) and NAV1 (NAV1 g.84216190 C>T; NAV1 g.84227412 G>A) genes are significantly associated (P <0.05) with immune and growth traits in Hu sheep, respectively. This research offers unique insights into the selection characteristics of Hu sheep and facilitates further genetic improvement and molecular investigations. Copyright (c) 2024, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. All rights reserved.

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