数字农科院2.0

Sustainable utilization of cottonseed meal: Integrated protein extraction and detoxification using deep eutectic solvents

文献类型： 外文期刊

作者： Tian Wang;Dehai Yu;Jian Wang;Bo Yang;Lei Ma;Shuangjiao Xu

作者机构：

关键词： Bound gossypol reduction;Cottonseed meal;Deep eutectic solvents;Functional properties;Mechanism exploration;Protein recovery

期刊名称： Food Chemistry

ISSN： 0308-8146

年卷期： 2025 年 485 卷

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： The growing demand for sustainable proteins has highlighted cottonseed meal (CSM) as a promising high-protein byproduct. Addressing the challenge of valorizing the annual global production of over 10 million tons of CSM in cottonseed processing, this study investigated the use of choline chloride-ethylene glycol deep eutectic solvent (DES-4) for efficient protein extraction from CSM while reducing toxic gossypol content. Through Box-Behnken response surface optimization, we established optimal conditions (56 °C/3 h/40% water) that achieved 86.85% protein yield while remarkably reducing bound gossypol content from 10.24 mg/g to 2.76 mg/g. Molecular dynamics simulations (MDS) revealed that DES-4 enhance protein recovery and gossypol separation through synergistic mechanisms involving stabilizing solubility, relaxing matrix structure, and disrupting complexes. The obtained protein (CSMP-E) demonstrated superior solubility, emulsifying properties, and antioxidant activity compared to alkali-extracted counterparts. Furthermore, hydrolyzed DES-extracted protein (CSMP-EH) exhibited enhanced DPP-IV inhibitory activity (IC50 = 1.949 mg/mL), suggesting its potential for type 2 diabetes management.

分类号：

  • 相关文献

[1]Sustainable utilization of cottonseed meal: Integrated protein extraction and detoxiffcation using deep eutectic solvents. . 2025

[2]Influence of oxidative browning inhibitors and isolation techniques on sweet potato protein recovery and composition. Arogundade, Lawrence A.,Mu, Tai-Hua,Arogundade, Lawrence A..

[3]Extraction and profiling of proteins in yellow powder from sweet potato starch wastewater using response surface methodology and proteomic approach. Yang, Shini,Liu, Haihua,Liao, Xiaojun,Kong, Xiankui,Xu, Zhenzhen. 2021

[4]Physicochemical And Functional Properties Of P.rotein Isolate Obtained From C ottonseed Meal. Zhou, Dayun,Kuang, Meng,Wang, Yanqin,Xie, Wei,Tang, Shurong,Ren, Yanjing,Du, Shuang-Kui,Ma, Mengting. 2018

[5]DNA degradation of genetically modified cottonseed meal during feed processing. Guan, Qingfeng,Wang, Xiumin,Teng, Da,Yang, Yalin,Wang, Jianhua,Guan, Qingfeng,Wang, Xiumin,Teng, Da,Yang, Yalin,Wang, Jianhua.

[6]Effects of different sources and levels of dietary gossypol on gossypol residues in plasma and milk of lactating cows. Wang, A. P.,Zhang, J. M.,Meng, Y. L.,Deng, L. Q.,Lv, Y. F.,Li, C.,Wang, J. Q.,Wang, A. P.,Lv, Y. F.. 2012

[7]Comparison of amino acid digestibility of soybean meal, cottonseed meal, and low-gossypol cottonseed meal between broilers and laying hens. Qiu, Kai,Wang, Xiao-cui,Wang, Jing,Wang, Hao,Qi, Guang-hai,Zhang, Hai-jun,Wu, Shu-geng. 2023

[8]Enhancing the quality of total mixed ration containing cottonseed or rapeseed meal by optimization of fermentation conditions. Hassan Ali Yusuf,Minyu Piao,Tao Ma,Ruiying Huo,Yan Tu. 2021

[9]Fermented Total Mixed Ration with Cottonseed Meal or Rapeseed Meal Improved Growth Performance and Meat Quality of Hu Lamb Compared to Total Mixed Ration with Soybean Meal. Hassan Ali Yusuf,Halidai Rehemujiang,Tao Ma,Minyu Piao,Ruiying Huo,Yan Tu. 2022

[10]Evaluating Fermentation Quality, Aerobic Stability, and Rumen-Degradation (In Situ) Characteristics of Various Protein-Based Total Mixed Rations. Halidai Rehemujiang,Hassan Ali Yusuf,Tao Ma,Qiyu Diao,Luxin Kong,Lingyun Kang,Yan Tu. 2023

[11]Fermented cottonseed and rapeseed meals outperform soybean meal in improving performance, rumen fermentation, and bacterial composition in Hu sheep. Halidai Rehemujiang,Hassan Ali Yusuf,Tao Ma,Qi Yu Diao,Luxin Kong,Lingyun Kang,Yan Tu. 2023

[12]Effect of lactic acid bacteria and yeast supplementation on anti-nutritional factors and chemical composition of fermented total mixed ration containing cottonseed meal or rapeseed meal. Yusuf, Hassan Ali,Piao, Minyu,Ma, Tao,Huo, Ruiying,Tu, Yan. 2022

[13]Dephenolization Methods, Quality Characteristics, Applications, and Advancements of Dephenolized Cottonseed Protein: Review. Xuegang Huang,Yumeng Hu,Zhenyuan Li,Bo Jiao,Xiaojie Ma,Qin Guo,Qiang Wang. 2025

[14]Functional Characteristics of Milk Protein Concentrates and Their Modification. Uluko, Hankie,Liu, Lu,Lv, Jia-Ping,Zhang, Shu-Wen,Uluko, Hankie.

[15]Functional properties of 8S globulin fractions from 15 mung bean (Vigna radiata (L.) Wilczek) cultivars. Liu, Hong,Liu, Hongkai,Yan, Lei,Kang, Yufan,Cheng, Xuzhen.

[16]Stirring Affects Starch Granule Morphology A.nd The Functional Properties O f Rice Flour. Wei, Xiangjin,Tang, Shaoqing,Sheng, Zhonghua,Shao, Gaoneng,Xie, Lihong,Xu, Qingguo,Jiao, Guiai,Jiao, Guiai,Hu, Peisong,Fiaz, Sajid. 2018

[17]Optimization of extraction efficiency by shear emulsifying assisted enzymatic hydrolysis and functional properties of dietary fiber from deoiled cumin (Cuminum cyminum L.). Ma, Mengmei,Mu, Taihua,Sun, Hongnan,Zhang, Miao,Chen, Jingwang,Yan, Zhibin.

[18]Comparative Studies On The Functional Properties Of Various Protein Concentrate Preparations Of Peanut Protein. Wu, Haiwen,Wang, Qiang,Ma, Tiezheng,Ren, Jiajia.

[19]Some characteristics and functional properties of rapeseed protein prepared by ultrasonication, ultrafiltration and isoelectric precipitation. Dong, Xu-Yan,Zhao, Yuan-Di,Dong, Xu-Yan,Guo, Lu-Lu,Wei, Fang,Li, Ju-Fang,Jiang, Mu-Lan,Li, Guang-Ming,Chen, Hong. 2011

[20]Influence of extraction and solubilizing treatments on the molecular structure and functional properties of peanut protein. Ma, Tiezheng,Zhu, Hongguang,Wang, Jing,Yu, Liangli (Lucy),Sun, Baoguo,Wang, Qiang,Yu, Liangli (Lucy).

作者其他论文 更多>>