数字农科院2.0

In vitro effects of structurally diverse low molecular weight chondroitin sulfates on gut microbiota and metabolome

文献类型： 外文期刊

作者： Kangyu Wang;Yue Liu;Yujie Guo;Chunhui Zhang

作者机构：

关键词： Gut microbiota;Low molecular weight chondroitin sulfate;Metabolism;Structure

期刊名称： International Journal of Biological Macromolecules

ISSN： 0141-8130

年卷期： 2025 年 310 卷

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： In this study, low molecular weight chondroitin sulfates (LMCSs) with different structures, named LMCSO, LMCSD, and LMCSH, were prepared by oxidative degradation, deamidation cleavage, and hydrothermal depolymerization, respectively. In vitro fermentation modeling was used to study the effects of CS and LMCSs on gut microbiota and metabolite composition. The degree of carbohydrate metabolism was in the order of CS > LMCSH > LMCSO > LMCSD. Significantly, GlcA in chondroitin-6-sulfate (CSC) was more readily utilized by gut microbiota during fermentation, and this trend was more pronounced in LMCSs. The LMCSs group notably increased microbial richness and evenness, especially in the LMCSD group. Bacteroides fragilis was identified as a potential primary degrader of CS and LMCSs through species-level analysis. The abundance of Escherichia-Shigella was reduced by LMCSs, and short-chain fatty acids production was enhanced, particularly by LMCSO, while the production of beneficial metabolites such as N-acetyl-D-Glucosamine 6-Phosphate (GlcNAc-6P), lactate, and progesterone was stimulated. Among these, the metabolism of the key metabolite GlcNAc-6P was significantly and positively correlated with the abundance of Bacteroides, Clostridium_sensu_stricto_1, and Parabacteroides. Exploring the mechanisms by which gut microbiota metabolize LMCSs with different structures can provide theoretical support for the targeted preparation of LMCSs that modulate the gut microbiota.

分类号：

  • 相关文献

[1]Orange Pectin with Compact Conformation Effectively Alleviates Acute Colitis in Mice. Jiefen Cui,Feng Wang,Chengying Zhao,Shuaishuai Zhou,Jinkai Zheng. 2022

[2]Alginate oligosaccharides increase boar semen quality by affecting gut microbiota and metabolites in blood and sperm. Han, Hui,Zhou, Yexun,Xiong, Bohui,Zhong, Ruqing,Jiang, Yue,Sun, Haiqing,Tan, Jiajian,Zhang, Bin,Guan, Chang,Schroyen, Martine,Chen, Liang,Zhao, Yong,Zhang, Hongfu. 2022

[3]Barley Vinegar Relieves Loperamide-Induced Constipation in Mice via the Modulation of the Gut Microbiota and Serum Metabolism. Yan Li,Aixia Wang,Mengzi Nie,Zhiying Chen,Lili Wang,Liya Liu,Fengzhong Wang,Litao Tong. 2023

[4]Jute (Corchorus olitorius L.) Nanocrystalline Cellulose Inhibits Insect Virus via Gut Microbiota and Metabolism. Yanchun Deng,Xiai Yang,Jiquan Chen,Sa Yang,Haiyang Chi,Chenxiao Chen,Xiushi Yang,Chunsheng Hou. 2023

[5]Editorial: Gut Microbial Response to Host Metabolic Phenotypes. Jie Yin,Yong Su,Hui Han. 2022

[6]Altered Fecal Microbiome and Correlations of the Metabolome with Plasma Metabolites in Dairy Cows with Left Displaced Abomasum. Luo, Zhengzhong,Yong, Kang,Luo, Qiao,Du, Zhenlong,Ma, Li,Huang, Yixin,Zhou, Tao,Yao, Xueping,Shen, Liuhong,Yu, Shumin,Deng, Junliang,Ren, Zhihua,Zhang, Yong,Yan, Zuoting,Zuo, Zhicai,Cao, Suizhong. 2022

[7]Effects of dietary phosphatidylcholine and sphingomyelin on DSS-induced colitis by regulating metabolism and gut microbiota in mice. Qiangqiang Li,Gang Chen,Dan Zhu,Wenwen Zhang,Suzhen Qi,Xiaofeng Xue,Kai Wang,Liming Wu. 2022

[8]Integrated Metagenomic and Transcriptomic Analyses Reveal the Dietary Dependent Recovery of Host Metabolism From Antibiotic Exposure. Bingbing Li,Huihui Qiu,Ningning Zheng,Gaosong Wu,Yu Gu,Jing Zhong,Ying Hong,Junli Ma,Wen Zhou,Lili Sheng,Houkai Li. 2021

[9]Comprehensive understanding the impacts of dietary exposure to polyethylene microplastics on genetically improved farmed tilapia (Oreochromis niloticus): tracking from growth, microbiota, metabolism to gene expressions. Xing Lu,Jie Xin Zhang,Lang Zhang,Di Wu,Juan Tian,Li Juan Yu,Li He,Shan Zhong,Hao Du,Dong Fang Deng,Yong Zhen Ding,Hua Wen,Ming Jiang. 2022

[10]Allergenicity Alleviation of Bee Pollen by Enzymatic Hydrolysis: Regulation in Mice Allergic Mediators, Metabolism, and Gut Microbiota. Yuxiao Tao,Enning Zhou,Fukai Li,Lifeng Meng,Qiangqiang Li,Liming Wu. 2022

[11]Cordyceps militaris solid medium extract alleviates lipopolysaccharide-induced acute lung injury via regulating gut microbiota and metabolism. Wang, Xiaoya,Zhang, Kang,Zhang, Jingyan,Xu, Guowei,Guo, Zhiting,Lu, Xiaorong,Liang, Chunhua,Gu, Xueyan,Huang, Liping,Liu, Shuqi,Wang, Lei,Li, Jianxi. 2025

[12]Bioavailability of Tea Polyphenols: A Key Factor in Understanding Their Mechanisms of Action In Vivo and Health Effects. Mingchuan Yang,Xiangchun Zhang,Chung S. Yang. 2025

[13]Polystyrene microplastics reduce honeybee survival by disrupting gut microbiota and metabolism. Han Li,Wangjiang Feng,Tong An,Pingli Dai,Yong Jun Liu. 2025

[14]In vitro digestive properties and the bioactive effect of walnut green husk on human gut microbiota. Xiaolan Zhao,Jiabao Ying,Zhuochen Wang,Yulu Wang,Zhen Li,Tianyi Gu,Shujun Liu,Yulong Li,Bing Liu,Fengjiao Xin,Boting Wen. 2024

[15]The multifaceted roles of gut microbiota in insect physiology, metabolism, and environmental adaptation: implications for pest management strategies. Kamran Haider,Dilawar Abbas,Jose Galian,Muhammad Adeel Ghafar,Kamil Kabir,Muhammad Ijaz,Mehboob Hussain,Khalid Ali Khan,Hamed A. Ghramh,Abbas Raza. 2025

[16]A fishy gut feeling - current knowledge on gut microbiota in teleosts. Tolas, Ingvill,Zhou, Zhigang,Zhang, Zhen,Teame, Tsegay,Olsen, Rolf Erik,Ringo, Einar,Ronnestad, Ivar. 2025

[17]Ginseng Soluble Dietary Fiber Reverses Obesity via the PPAR/AMPK Signaling Pathway and Improves Intestinal Flora in Mice. Yue Zhang,Chen Bai,Jiyue Sha,Xiaohui Huo,Di Qu,Jianbo Chen. 2025

[18]Analyses of the NAC Transcription Factor Gene Family in Gossypium raimondii Ulbr.: Chromosomal Location, Structure, Phylogeny, and Expression Patterns. Haihong Shang ,Wei Li,Changsong Zou,Youlu Yuan. 2013

[19]Structure and digestion of hybrid Indica rice starch and its biosynthesis. Kuang, Qirong,Xu, Jinchuan,Zhou, Sumei,Liu, Xingxun,Wang, Kai.

[20]Structure elucidation and toxicity analyses of the radiolytic products of aflatoxin B-1 in methanol-water solution. Wang, Feng,Xie, Fang,Wang, Zhidong,Fan, Bei,Ha, Yiming,Wang, Feng,Xie, Fang,Wang, Zhidong,Fan, Bei,Ha, Yiming,Wang, Feng,Xue, Xiaofeng. 2011

作者其他论文 更多>>