文献类型: 外文期刊
作者: Xing Zheng;Xue Wang;Qingyu Wang;Mengyao Liu;Wenjun Peng;Yazhou Zhao
作者机构:
关键词: Bee sting;Bee venom;Metabolomics;Organ damage;Toxic reactions
期刊名称: Toxicon
ISSN: 0041-0101
年卷期: 2023 年 231 卷
页码:
收录情况: SCIE(2023版)
摘要: With the development of beekeeping, the risk of bee stings in humans is increasing. Severe and life-threatening toxic reactions can occur after multiple bee stings, and their pathogenesis has not been elucidated. To understand the effect of multiple bees (Apis mellifera) stings on the organism in a short period, we stung rats once and five times, respectively. Serum and organs were obtained after 3 h for analysis. The results indicated that skin erythema was more pronounced and hemolysis was more severe as the number of puncture wounds increased. After being stung by five bees, rats had dramatically higher serum levels of direct bilirubin, aspartate aminotransferase, creatine kinase and lactate dehydrogenase, producing more differential metabolites that affected mainly four metabolic pathways. In addition, the liver, kidney and heart showed significant congestion and inflammation. This study helps explain the organism's clinical response to bee venom and may be valuable in treating toxic reactions following bee stings.
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