数字农科院2.0

Flexible chemiresistor biosensor array using PDMS, cellulose paper and semiconducting single-walled carbon nanotubes for simultaneous detection of ochratoxin A, deoxynivalenol, and zearalenone

文献类型： 外文期刊

作者： Yue He;Hui Wang;Zhixue Yu;Ruipeng Chen;Mengting Zhou;Yuming Guo;Xiangfang Tang;Benhai Xiong

作者机构：

关键词： Cellulose paper;Chemiresistor;Mycotoxins;Semiconducting single-walled carbon nanotubes;Simultaneous detection

期刊名称： Microchemical Journal

ISSN： 0026-265X

年卷期： 2025 年 213 卷

页码：

收录情况： SCIE（2025版）

摘要： Multiple mycotoxins in foodstuffs and feeds are hazards to human and animal health through direct cell damage, immune suppression, genotoxicity, endocrine disruption, and nervous system harm. Herein, a low-cost paper-based chemiresistor biosensor array was established for the simultaneous determination of ochratoxin A (OTA), deoxynivalenol (DON), and zearalenone (ZEN). To overcome the poor mechanical properties, PDMS was introduced to fabricate a triple-channel electrochemical biosensor on cellulose paper, which was applied the single-wall carbon nanotubes (SWCNTs) and semiconducting SWCNTs (s-SWCNTs) as the conductive electrodes and sensitive material. The coupling conditions of antibody proteins with s-SWCNTs were discussed in detail, which a method using only EDC as the activating agent was employed to immobilize three bovine serum albumin conjugates (OTA-BSA, DON-BSA, and ZEN-BSA). After exploring optimal conditions of the chemiresistor biosensor array, the limit of detections for OTA, DON, and ZEN are determined to be 0.26, 0.45, and 0.21 pg/mL, respectively. The biosensor array was applied to detect mycotoxins in corn, demonstrating it possesses potential value for simultaneously determining multiple targets.

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