数字农科院2.0

Residue risk assessment and enantioselective analysis of Fenpropimorph in tea and agricultural products by UHPLC-MS/MS

文献类型： 外文期刊

作者： Xinzhong Zhang;Min Wang;Yating Ning;Yue Hu;Yan Zhao;Mei Yang;Hezhi Sun;Xinru Wang;Li Zhou;Fengjian Luo

作者机构：

关键词： Enantioselective residue;Fenpropimorph;Risk assessment;Tea;UHPLC-MS/MS

期刊名称： Microchemical Journal

ISSN： 0026-265X

年卷期： 2025 年 219 卷

页码：

收录情况： SCIE（2025版）

摘要： Fenpropimorph was specifically developed for controlling powdery mildew and other various plant diseases. However, despite its widespread use in agricultural production, there have been few reports on the enantiomeric residues of fenpropimorph. In this research, a modified QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) extraction and purification method combined with ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) analysis was first established and validated for quantifying the residues of fenpropimorph enantiomers in various tea varieties and other agricultural products. Enantiomeric separation of fenpropimorph was successfully achieved using a Lux 3 μ Cellulose-3 chiral column. The mobile phases consisted of water containing 5 mmol/L ammonium acetate and acetonitrile containing 0.1 % formic acid, and a gradient elution program was employed. Under these conditions, (−)-fenpropimorph was eluted prior to (+)-fenpropimorph. This is the first report on the separation of fenpropimorph enantiomers via reversed-phase liquid chromatography (RPLC), which clarifies both the configurations and elution sequences of fenpropimorph enantiomers. For method validation, recoveries of fenpropimorph enantiomers at four spiked levels in different samples ranged from 74.3 % to 112.0 %, with relative standard deviations (RSDs) below 17.8 %. The limits of quantification (LOQs) were determined to be 0.0005 mg/kg in romaine lettuce, 0.001 mg/kg in wheat flour, peas, and fresh tea leaves, and 0.0025 mg/kg in dried pepper and various tea samples. This newly developed method was subsequently applied to track the residue dynamics of fenpropimorph enantiomers throughout the green tea production chain, from tea cultivation to the final cup of tea. The results showed that the half-lives (t1/2) of (−)-fenpropimorph and (+)-fenpropimorph in growing tea plants were 3.45 days and 3.48 days, respectively, with enantiomeric fraction (EF) values ranging from 0.496 to 0.504. Five days after the application of fenpropimorph at a rate of 300 g active ingredient (a.i.) per hectare, the terminal residues of (−)-fenpropimorph and (+)-fenpropimorph were determined to be 1.92 mg/kg and 1.89 mg/kg in fresh tea leaves, and 7.43 mg/kg and 7.92 mg/kg in processed green tea, respectively. Based on these findings and combined with a dietary intake risk assessment, it is recommended that the pre-harvest interval (PHI) for fenpropimorph in tea gardens be set at 5 days, additionally, the maximum residue limit (MRL) for both (−)-fenpropimorph and (+)-fenpropimorph in green tea can be set at 10 mg/kg.

分类号：

  • 相关文献

[1]Quantitative tracing of typical herbicides and their metabolites in sorghum agrosystems for fate tendency and cumulative risk. Li, Tong,Wu, Xujin,Zheng, Lufei,Cheng, Youpu,Zhao, Lilin,Chen, Zenglong. 2024

[2]Occurrence and risk assessment of organophosphorus pesticide residues in Chinese tea. Chen, Hongping,Hao, Zhenxia,Wang, Qinghua,Jiang, Ying,Pan, Rong,Wang, Chen,Liu, Xin,Lu, Chengyin,Chen, Hongping,Hao, Zhenxia,Wang, Qinghua,Jiang, Ying,Wang, Chen,Liu, Xin,Lu, Chengyin,Chen, Hongping,Hao, Zhenxia,Wang, Qinghua,Jiang, Ying,Wang, Chen,Liu, Xin,Lu, Chengyin,Pan, Rong.

[3]Residue pattern of chlorpyrifos and its metabolite in tea from cultivation to consumption. Peng Yin,Jinxia Dai,Guiyi Guo,Zihao Wang,Wei Liu,Xin Liu,Hongping Chen. 2021

[4]Residue degradation, transfer and risk assessment of pyriproxyfen and its metabolites from tea garden to cup by ultra performance liquid chromatography tandem mass spectrometry. Li, Hongxia,Zhong, Qing,Wang, Min,Luo, Fengjian,Wang, Xinru,Zhou, Li,Zhang, Xinzhong. 2021

[5]Concentrations, generation and risk characterization of phthalimide in tea-derived from folpet or not?. Sun H.,Zhang X.,Zuo W.,Dai Z.,Zhou L.,Luo F.,Yang M.,Wang X.,Lou Z.,Chen Z.. 2022

[6]Comparison of Combined Dissipation Behaviors and Dietary Risk Assessments of Thiamethoxam, Bifenthrin, Dinotefuran, and Their Mixtures in Tea. Tiancai Wang,Yongzhong Qian,Jieqiong Wang,Xueyan Yin,Qifu Liang,Guangqin Liao,Xiabing Li,Jing Qiu,Yanyang Xu. 2024

[7]Selecting a representative tea for risk assessment of pesticide residue in tea:Afidopyropen as a case. Mingming Guo,Zhaoqun Li,Yujie Qin,Kexin Qian,Chi Su,Jiawei Yu,Hezhi Sun,Xinzhong Zhang,Xinru Wang,Mei Yang,Fengjian Luo,Zongmao Chen,Li Zhou. 2025

[8]Residue pattern and risk assessment of validamycin A and spinosyn A in tea using hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry. Aiping Li,Chen Wang,Yunfeng Chai,Zhiming Huang,Binbin Yao,Chengyin Lu,Miao Yu,Hongping Chen. 2025

[9]Residual dissipation and dietary risk assessment of mefentrifluconazole enantiomers from tea bushes to consumer products. Zhang, Ying,Wang, Fang,Shi, Guiyuan,Huang, Wenyuan,Long, Jiahuan,Chen, Hongping,Duan, Tingting,Zhang, Xinzhong. 2025

[10]液相色谱串联质谱法检测草铵膦、草甘膦及其代谢物在水和土壤中的残留. 姬乐园,王平平,朱丽珍,毛连纲,张兰,蒋红云,刘新刚. 2024

[11]Simultaneous determination of aflatoxin M-1, ochratoxin A, zearalenone and alpha-zearalenol in milk by UHPLC-MS/MS. Huang, L. C.,Zheng, N.,Wen, F.,Cheng, J. B.,Han, R. W.,Xu, X. M.,Li, S. L.,Wang, J. Q.,Huang, L. C.,Cheng, J. B.,Zheng, B. Q.,Huang, L. C.,Zheng, N.,Wen, F.,Han, R. W.,Xu, X. M.,Li, S. L.,Wang, J. Q.,Wang, J. Q.. 2014

[12]Simultaneous determination of penflufen and one metabolite in vegetables and cereals using a modified quick, easy, cheap, effective, rugged, and safe method and liquid chromatography coupled to tandem mass spectrometry. Tian, Fajun,Liu, Xingang,Xu, Jun,Dong, Fengshou,Wu, Xiaohu,Zheng, Yongquan,Tian, Fajun,Wu, Yanbing.

[13]Simultaneous Determination of Phoxim, Chlorpyrifos, and Pyridaben Residues in Edible Mushrooms by High-Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry. Tian, Fajun,Liu, Xingang,Xu, Jun,Dong, Fengshou,Zheng, Yongquan,Hu, Mingfeng,Wu, Yanbing,Tian, Fajun,Wu, Yanbing.

[14]Simultaneous determination of spirotetramat and its four metabolites in fruits and vegetables using a modified quick, easy, cheap, effective, rugged, and safe method and liquid chromatography/tandem mass spectrometry. Liu, Xingang,Xu, Jun,Dong, Fengshou,Liang, Xuyang,Li, Minmin,Zheng, Yongquan,Duan, Lifang.

[15]A metabolomics approach revealed an Amadori compound distinguishes artificially heated and naturally matured acacia honey. Sha Yan,Xuan Wang,Yuchen Wu,Kai Wang,Jihao Shan,Xiaofeng Xue. 2022

[16]Simultaneous determination of succinate-dehydrogenase-inhibitor fungicide traces in cereals by QuEChERS preparation and UPLC-MS/MS analysis. Haoran Zhao,Minmin Li,Xiaowei Liu,Jiajie Yang,Xueyao Li,Jieyin Chen,Xiaofeng Dai,Jesus Simal-Gandara,Zhiqiang Kong,Zhizhong Li. 2022

[17]Ultra-high performance liquid chromatography and gas chromatography coupled to tandem mass spectrometry for the analysis of 32 pyrethroid pesticides in fruits and vegetables: A comparative study. Yuan H.,Li B.,Wei J.,Liu X.,He Z.. 2023

[18]Penicillium And Patulin Distribution In P.ears Contaminated With Penicillium E xpansum. Determination Of Patulin In Pears By Uhplcms/Ms. Wei, DM,Xu, J,Dong, FS,Liu, XG,Wu, XH,Zheng, YQ. 2017

[19]An integrated bile acids profile determination by uhplc-ms/ms to identify the effect of bile acids supplement in high plant protein diet on common carp (Cyprinus carpio). Xian Wei,Ting Yao,Fatou Ndoye Fall,Min Xue,Xiaofang Liang,Jie Wang,Wenlong Du,Xu Gu. 2021

[20]Development and validation of a method for the analysis of trifludimoxazin, picarbutrazox and pyraziflumid residues in cereals, vegetables and fruits using ultra-performance liquid chromatography/tandem mass spectrometry. Fajun Tian,Chengkui Qiao,Caixia Wang,Jing Luo,Linlin Guo,Tao Pang,Jun Li,Ruiping Wang,Rongli Pang,Hanzhong Xie. 2021

作者其他论文 更多>>