数字农科院2.0

Response Surface Methodology Optimization on Ultrasonic-Assisted Extraction of Chicory (Cichorium intybus L.) and Their UPLC-ESI-QTOF-MS Analysis, Antioxidant and Hepatoprotective Activity

文献类型： 外文期刊

作者： Baiseitova, Aizhamal;Amzeyeva, Ulpan;Tolepbergen, Aiya;Ulfanova, Yasmina;Shybyray, Yergazy;Dai, Lixia;Shang, Xiaofei;Shah, Abdul Bari;Kim, Jeong Yoon;Jenis, Janar

作者机构：

关键词： antioxidant;Chicory (Cichorium intybus L.);hepatoprotective;response surface methodology (RSM);UPLC-ESI-QTOF/MS

期刊名称： EFOOD

ISSN：

年卷期： 2025 年 6 卷 4 期

页码：

收录情况： EI（2025版） ; ; ESCI（2025版）

摘要： Chicory (Cichorium intybus L.) roots are commonly roasted and ground to produce a coffee alternative, valued for its robust, nutty taste and absence of caffeine. Historically, it has been utilized to facilitate digestion, serve as a diuretic, and promote liver function. This study employed a response surface methodology (RSM) for optimization the ultrasonic-assisted extraction of antioxidant composition from chicory. The optimal extraction conditions (temperature 60 degrees C, extraction duration 4 h, and solid-to-solvent ratio of 1:20 g/mL) resulted in the maximum yield and antioxidant capacity. The metabolic content of chicory extract, prepared under optimal conditions, was found by UPLC-ESI-QTOF/MS, including aesculetin, caftaric acid, caffeoylmalic acid, scopoletin, and chicoric acid. Moreover, chicory extracts derived under identical conditions in two distinct solvents (96% and 50% ethanol) demonstrated vitality and hepatoprotective action in HL-7702 cells. This study may offer a perspective for acquiring potential extracts of chicory as a functional food.

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