数字农科院2.0

An NLR paralog Pit2 generated from tandem duplication of Pit1 fine-tunes Pit1 localization and function

文献类型： 外文期刊

作者： Yuying Li;Qiong Wang;Huimin Jia;Kazuya Ishikawa;Ken Ichi Kosami;Takahiro Ueba;Atsumi Tsujimoto;Miki Yamanaka;Yasuyuki Yabumoto;Daisuke Miki;Eriko Sasaki;Yoichiro Fukao;Masayuki Fujiwara;Takako Kaneko-Kawano;Li Tan;Chojiro Kojima;Rod A. Wing;Alfino Sebastian;Hideki Nishimura;Fumi Fukada;Qingfeng Niu;Motoki Shimizu;Kentaro Yoshida;Ryohei Terauchi;Ko Shimamoto;Yoji Kawano

作者机构：

关键词： （1-0-1）

期刊名称： Nature Communications

ISSN： 2041-1723

年卷期： 2024 年 15 卷 1 期

页码：

收录情况： SCIE（2024版）

摘要： NLR family proteins act as intracellular receptors. Gene duplication amplifies the number of NLR genes, and subsequent mutations occasionally provide modifications to the second gene that benefits immunity. However, evolutionary processes after gene duplication and functional relationships between duplicated NLRs remain largely unclear. Here, we report that the rice NLR protein Pit1 is associated with its paralogue Pit2. The two are required for the resistance to rice blast fungus but have different functions: Pit1 induces cell death, while Pit2 competitively suppresses Pit1-mediated cell death. During evolution, the suppression of Pit1 by Pit2 was probably generated through positive selection on two fate-determining residues in the NB-ARC domain of Pit2, which account for functional differences between Pit1 and Pit2. Consequently, Pit2 lost its plasma membrane localization but acquired a new function to interfere with Pit1 in the cytosol. These findings illuminate the evolutionary trajectory of tandemly duplicated NLR genes after gene duplication.

分类号：

  • 相关文献

[1]序言:DNA数据存储技术与应用. 戴俊彪,姜青山,钱珑,黄小罗. 2024

[2]Harnessing Landrace Diversity Empowers Wheat Breeding（副）. Shifeng Cheng1 ,#,* , Cong Feng1,*, Luzie U. Wingen2,*, Hong Cheng1 , Andrew B. Riche3 , Mei Jiang1 , Michelle Leverington-Waite2 , Zejian Huang1 , Sarah Collier2 , Simon Orford2 , Xiaoming Wang2,4, Rajani Awal2 , Gary Barker5 , Tom O’’Hara2 , Clare Lister2 , Ajay Siluveru2 , Jesús Quiroz-Chávez2 , Ricardo H. Ramírez-González2 , Ruth Bryant6 , Simon Berry7 , Urmil Bansal8 , Harbans S. Bariana8,9, Malcolm J. Bennett10, Breno Bicego11, Lorelei Bilham2 , James K.M. Brown2 , Amanda Burridge5 , Chris Burt6 , Milika Buurman12, March Castle3 , Laetitia Chartrain2 , Baizhi Chen1 , Worku Denbel13, Ahmed F. Elkot14, Paul Fenwick15, David Feuerhelm16, John Foulkes10, Oorbessy Gaju10, Adam Gauley17,18, Kumar Gaurav2 , Amber N. Hafeez2 , Ruirui Han1,19, Richard Horler2 , Junliang Hou1 , Muhammad S. Iqbal1 , Matthew Kerton20, Ankica Kondic-Spica21, Ania Kowalski2 , Jacob Lage22, Xiaolong Li23, Hongbing Liu1 , Shiyan Liu1 , Alison Lovegrove3 , Lingling Ma1 , Cathy Mumford2 , Saroj Parmar3 , Charlie Philp2 , Darryl Playford2 , Alexandra M. Przewieslik-Allen5 , Zareen Sarfraz1 , David Schafer6 , Peter R. Shewry3 , Yan Shi1 , Gustavo Slafer11, Baoxing Song24, Bo Song1 , David Steele3 , Burkhard Steuernagel2 , Phillip Tailby7 , Simon Tyrrell25, Abdul Waheed1 , Mercy N. Wamalwa26, Xingwei Wang1 , Yanping Wei1 , Mark Winfield5 , Shishi Wu1 , Yubing Wu1,27, Brande B.H. Wulff2,28, Wenfei Xian1,29, Yawen Xu1,27, Yunfeng Xu1 , Quan Yuan1 , Xin Zhang1,27, Keith J. Edwards5 , Laura Dixon17, Paul Nicholson2 , Noam Chayut2 , Malcolm J. Hawkesford3 , Cristobal Uauy2 , Dale Sanders2 , Sanwen Huang1,30, Simon Griffiths2 ,#. 2024

[3]Selfing Promotes Spread and Introgression of Segregation Distorters in Hermaphroditic Plants. Hongru Wang,Léo Planche,Vladimir Shchur,Rasmus Nielsen. 2024

[4]The transcription factor WRKY41-FLAVONOID 3′-HYDROXYLASE module fine-tunes flavonoid metabolism and cold tolerance in potato. Bao, Huihui,Yuan, Li,Luo, Yongchao,Zhang, Jinxiu,Liu, Xi,Wu, Qiuju,Wang, Xiyao,Liu, Jitao,Zhu, Guangtao. 2025

[5]Targeting conserved secreted effectors to control rice blast. Zhang, Chongyang,Feng, Qin,Ruan, Jue,Wang, Guo-Liang,You, Xiaoman,Ning, Yuese. 2025

[6]Predicting functions of uncharacterized gene products from microbial communities. Zhang, Yancong,Bhosle, Amrisha,Bae, Sena,Eckenrode, Kelly,Huang, Xueying,Tang, Jingjing,Lavrentovich, Danylo,Awad, Lana,Hua, Ji,Wang, Ya,Morgan, Xochitl C.,Li, Bin,Krueger, Andy,Garrett, Wendy S.,Franzosa, Eric A.,Huttenhower, Curtis. 2025

[7]Editorial – Novel Genetic Controls and Biotechnologies to Facilitate the Management of Insect Pests. 万方浩. 2025

作者其他论文 更多>>