数字农科院2.0

A polarity-sensitive fluorescent probe for monitoring liver disease and edible oil quality

文献类型： 外文期刊

作者： Kaifu Ma;Peng Zhang;Yu Zhang;Mingyue Zheng;Na Xiao;Zhiman Li;Wei Shu

作者机构：

关键词： Alcoholic liver disease;Edible oils;Fluorescent probe;Polarity

期刊名称： Microchemical Journal

ISSN： 0026-265X

年卷期： 2025 年 218 卷

页码：

收录情况： SCIE（2025版）

摘要： Polarity serves as a critical indicator for both food quality monitoring and disease diagnosis, reflecting quality in food products and cellular metabolic status in biological systems. In this work, we developed a novel polarity-sensitive fluorescent probe, TCF-TP-TPA, based on an intramolecular charge transfer mechanism. TCF-TP-TPA exhibits remarkable sensitivity to environmental polarity changes, demonstrating significant fluorescence enhancement in low-polarity conditions. With excellent photostability and pH tolerance, TCF-TP-TPA shows outstanding performance in complex biological and food matrices. Biological applications reveal its capability for real-time monitoring of liver injury progression. In food safety applications, TCF-TP-TPA enables rapid polarity assessment of edible oils, providing a reliable approach for quality control. This work not only presents an advanced molecular tool for polarity detection but also offers promising solutions for clinical diagnosis and food safety monitoring.

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