数字农科院2.0

Uricolytic Bacillus from medicinal-edible plants ameliorates hyperuricemia in geese

文献类型： 外文期刊

作者： Wei, Chao;Cao, Junxuan;Hu, Boyang;Du, Zetao;Zhang, Hongyu;Dai, Yujie;Peng, Ao;Liao, Yanyang;Zou, Zhaoxia;Xie, Chunliang;Chen, Jinjun

作者机构：

关键词： Uricolytic activity;Endophytic bacillus;Goose;Hyperuricemia;Medicinal-edible plant

期刊名称： ARCHIVES OF MICROBIOLOGY

ISSN： 0302-8933

年卷期： 2025 年 207 卷 12 期

页码：

收录情况： SCIE（2025版）

摘要： Humans and poultry are both susceptible to hyperuricemia, due to mutations in the uric acid oxidase gene. Chinese medicinal-edible plants have been extensively utilized in the management of hyperuricemia. Extracts of medicinal-edible plants have been extensively studied in the treatment of hyperuricemia. However, the endophytic bacteria in these medicinal-edible plants have been rarely studied. In the present study, four strains of Bacillus with uricolytic activity were isolated and identified from four medicinal-edible plants. The strain with the highest uricolytic activity comes from sunflowers and is a novel species named XRK-1. The 16 S rRNA sequence of XRK-1 shares 96.3% homology with the most similar Ornithinibacillus salinisoli LCB256 (14-AUG-2023). After evaluating the safety and the tolerance of acid and choline in vitro, XRK-1 with 107 CFU/kg was added to goose feed daily for 3 weeks. The results of the preliminary animal trials showed that the serum uric acid levels of 1-day-old and 21-day-old geese fed with XRK-1 decreased by 32.5% and 15.0% respectively compared to the control group. These findings suggest that endophytes with uricolytic activity in medicinal-edible plants play a certain role in the management of hyperuricemia in plant dietary therapy.

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