数字农科院2.0

Longitudinal multi-omics decipher chlorinated paraffin 52 disruption of gut-brain axis homeostasis in HFD-fed mice

文献类型： 外文期刊

作者： Wang, Yanan;Dong, Shujun;Zhang, Qi;Zhang, Ruiyi;Zhang, Hao;Huang, Kunlun;Cheng, Nan

作者机构：

关键词： Chlorinated paraffin;High-fat diet;Gut-brain axis;Gut microbiota;Brain injury

期刊名称： ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

ISSN： 0147-6513

年卷期： 2025 年 306 卷

页码：

收录情况： SCIE（2025版）

摘要： The global rise in metabolic diseases linked to high-fat diet (HFD) patterns has coincided with the emergence of chlorinated paraffins (CPs) as persistent, toxic environmental contaminants detected across food systems, raising dual concerns for public health. While studies have demonstrated CPs-induced intestinal damage and neurotoxicity in bee and zebrafish models, their effects on gut-brain axis homeostasis in HFD-fed mice under metabolic disease conditions remain unexplored. Here, we found that CP52 disrupt intestinal homeostasis, impair barrier function, reduce tight junction protein expression, and induce mucosal damage and enterocyte apoptosis. Concurrently, CP52 exposure triggers neuronal damage, Tau protein accumulation, and activation of neurodegenerative signaling pathways under HFD condition. The observed changes in metabolites serve as a critical bridge, linking the pronounced association between gut dysbiosis and brain damage. Our findings reveal that CPs disrupt gut-brain axis homeostasis under HFD conditions, elucidating the complex toxicity mechanisms of CP52, which significantly impair intestinal physiology and the brain microenvironment, thereby emphasizing the urgent need to address CPs contamination in metabolic health.

分类号：

  • 相关文献

[1]A fishy gut feeling - current knowledge on gut microbiota in teleosts. Tolas, Ingvill,Zhou, Zhigang,Zhang, Zhen,Teame, Tsegay,Olsen, Rolf Erik,Ringo, Einar,Ronnestad, Ivar. 2025

[2]High-fat diet-disturbed gut microbiota-colonocyte interactions contribute to dysregulating peripheral tryptophan-kynurenine metabolism. Penghao Sun,Mengli Wang,Yong Xin Liu,Luqi Li,Xuejun Chai,Wei Zheng,Shulin Chen,Xiaoyan Zhu,Shanting Zhao. 2023

[3]DHA Suppresses Hepatic Lipid Accumulation via Cyclin D1 in Zebrafish. Qianwen Ding,Qiang Hao,Qingshuang Zhang,Yalin Yang,Rolf Erik Olsen,Einar Ringø,Chao Ran,Zhen Zhang,Zhigang Zhou. 2022

[4]Targeted microbiome metabolomics reveals flaxseed oil supplementation regulated the gut microbiota and farnesoid X receptor pathway in high-fat diet mice. Chen Yang,Zhenxia Xu,Qingde Huang,Xu Wang,Fenghong Huang,Qianchun Deng. 2023

[5]Nuclease treatment enhanced the ameliorative effect of yeast culture on epidermal mucus, hepatic lipid metabolism, inflammation response and gut microbiota in high-fat diet-fed zebrafish. Yajie Zhao,Qiang Hao,Qingshuang Zhang,Yalin Yang,Chao Ran,Qiyou Xu,Chenglong Wu,Wenshu Liu,Siming Li,Zhen Zhang,Zhigang Zhou. 2022

[6]Addition of solid-state fermentation product of yeast ameliorated the effects of high-fat diet on hepatic lipid metabolism, epidermal mucus, intestine and liver health, and gut microbiota of zebrafish. Jie Li,Dongmei Xia,Xiufang Jing,Yajie Zhao,Qiang Hao,Qingshuang Zhang,Mingxu Xie,Yalin Yang,Chao Ran,Qiyou Xu,Chenglong Wu,Zhen Zhang,Zhigang Zhou. 2023

[7]Reconstituting gut microbiota-colonocyte interactions reverses diet-induced cognitive deficits: The beneficial of eucommiae cortex polysaccharides. Mengli Wang,Penghao Sun,Xuejun Chai,Yong Xin Liu,Luqi Li,Wei Zheng,Shulin Chen,Xiaoyan Zhu,Shanting Zhao. 2024

[8]In Vitro Evaluation of Probiotic Activities and Anti-Obesity Effects of Enterococcus faecalis EF-1 in Mice Fed a High-Fat Diet. Hongying Cai,Qingya Wang,Xiling Han,Haiou Zhang,Na Wang,Yuyin Huang,Peilong Yang,Rui Zhang,Kun Meng. 2024

[9]Gut microbiota dysbiosis and oxidative damage in high-fat diet-induced impairment of spermatogenesis: Role of protocatechuic acid intervention. Hu, Ruizhi,Yang, Xizi,Wang, Long,Su, Dingding,He, Ziyu,Li, Jiaxing,Gong, Jiatai,Zhang, Wentao,Ma, Siqi,Shi, Mingkun,Lv, Jing,Zhang, Qianjin,Hou, De-Xing,Zhang, Hongfu,He, Jianhua,Yin, Yulong,Wang, Jun,Wu, Shusong. 2024

[10]The effects of sodium propionate on intestinal barrier function of genetically improved farmed tilapia in a high-lipid formulation. Ding, Qianwen,Hao, Qiang,Jin, Ya,Zhang, Qingshuang,Xie, Yadong,Yang, Yalin,Olsen, Rolf Erik,Ringo, Einar,Ran, Chao,Zhang, Zhen,Zhou, Zhigang. 2024

[11]Probiotic Potentials and Protective Effects of Ligilactobacillus animalis LA-1 Against High-Fat Diet-Induced Obesity in Mice. Qingya Wang,Yuyin Huang,Kun Meng,Haiou Zhang,Yunsheng Han,Rui Zhang,Xiling Han,Guohua Liu,Hongying Cai,Peilong Yang. 2025

[12]The gut microbiota-brain axis in neurological disorder. Ullah, Hanif,Arbab, Safia,Tian, Yali,Liu, Chang-qing,Chen, Yuwen,Qijie, Li,Khan, Muhammad Inayat Ullah,Hassan, Inam Ul,Li, Ka. 2023

[13]Bisphenol A Analogues Induce Neuroendocrine Disruption via Gut-Brain Regulation in Zebrafish. Mu, Xiyan,Liu, Zaiteng,Zhao, Xiaoyu,Yuan, Lilai,Li, Yingren,Wang, Chengju,Xiao, Guohua,Mu, Jiandong,Qiu, Jing,Qian, Yongzhong. 2024

[14]Short- and medium-chain chlorinated paraffins in green tea from 11 Chinese provinces and their migration from packaging. Yujiao Wang,Xingyi Wu,Yaxin Wang,Su Zhang,Shujun Dong,Wenfeng Zhou. 2022

[15]Short- And Medium-Chain Chlorinated Paraffins In Plastic Animal Feed Packaging And Factors Affect Their Migration Into Animal Feed. Dong, SJ, Zhang, S, Li, XM, Li, T, Fan, MD, Wang, YX, Cheng, J, Wang, RG, Zou, Y, Wang, S, Suo, DC, Wang, PL, Su, XO. 2020

[16]Short- and medium-chain chlorinated paraffins in honey from China: Distribution, source analysis, and risk assessment. Shujun Dong,Suzhen Qi,Su Zhang,Yaxin Wang,Yin Zhao,Yun Zou,Yiming Luo,Peilong Wang,Liming Wu. 2022

[17]Cattle hair as a bioindicator for short- and medium-chain chlorinated paraffin monitoring on cattle farms. Shujun Dong,Su Zhang,Decheng Suo,Xingyi Wu,Xiaoxu Han,Meng Liang,Jun Cao,Yun Zou,Xiaoyan Pei,Peilong Wang. 2024

[18]A preliminary study on short- and medium-chain chlorinated paraffins in duck farms: Concentrations, distribution, and dietary exposure risks. Shujun Dong,Su Zhang,Xingyi Wu,Jun Cao,Ming Yan,Yun Zou,Han Yan,Jian Tang,Decheng Suo,Peilong Wang. 2024

[19]Bee colonies map the short- and medium-chain chlorinated paraffin contamination from the apiary environment. Shujun Dong,Suzhen Qi,Yazhou Zhao,Su Zhang,Xingyi Wu,Jun Cao,Yun Zou,Yuesen Wang,Simeng Xia,Peilong Wang,Liming Wu. 2024

[20]Concurrence, packaging effects, and risks of short- and medium-chain chlorinated paraffins in commercial dairy products. Yaqun Fan,Meng Liang,Jianing Xin,Xingyi Wu,Xiaoxu Han,Hongyan Xu,Su Zhang,Yun Zou,Shujun Dong,Peilong Wang. 2025

作者其他论文 更多>>