数字农科院2.0

Inflammation-targeted nanoplatform: NIR-II imaging-guided encephalitis suppressing by dual antioxidant-ferroptosis action

文献类型： 外文期刊

作者： Qianruo Wang;Di Wang;Penghui Liu;Ben Zhong Tang;Yuanyuan Li;Xin Yin

作者机构：

关键词： Encephalitis;Ferroptosis;Inflammation-targeted;Oxygen species

期刊名称： Biomaterials

ISSN： 0142-9612

年卷期： 2025 年 327 卷

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： Encephalitis, a life-threatening neurological disorder with high mortality and debilitating long-term sequelae, remains a formidable clinical challenge due to limited therapeutic strategies targeting its underlying pathological mechanisms. Current interventions, constrained by blood-brain barrier (BBB) impermeability and a focus on symptomatic relief, fail to mitigate ferroptosis and reactive oxygen species (ROS)-mediated neurotoxicity—central drivers of disease progression. Here, we present CeO2/3TT@NP-RVG, a multifunctional nanomaterial engineered for integrated diagnosis and treatment of encephalitis. The nanoplatform combines ROS-scavenging cerium oxide (CeO2) with photothermal NIR–II–emissive (3TT) nanoparticles, enabling real-time fluorescence imaging of encephalitis with deep-tissue resolution. Functionalization with rabies virus glycoprotein-derived RVG peptide ensures BBB penetration and neuron-targeted delivery. In LPS-induced encephalitis models, CeO2/3TT@NP-RVG demonstrated dual therapeutic efficacy: alleviating oxidative stress by neutralizing ROS, suppressing pro-inflammatory cytokines (TNF-α, IFN-β), and inhibiting ferroptosis via ubiquitination-mediated downregulation of the POR-ACSL4-LPCAT3 pathway, thereby reducing polyunsaturated fatty acid peroxidation. These synergistic actions significantly improved survival rates and mitigated neuroinflammation. Our findings highlight CeO2/3TT@NP-RVG as a pioneering theranostic platform that bridges molecular mechanism-based therapy with precision imaging, offering a transformative strategy for encephalitis and related neurological disorders.

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