数字农科院2.0

Replication, pathogenicity, and transmission of SARS-CoV-2 in minks

文献类型： 外文期刊

作者： 帅磊;;钟功勋;;温志远;;王翀;;何希君;;刘任强;;王金良;;施建忠;;陈化兰;;步志高

作者机构：

关键词： SARS-CoV-2; mink; replication; pathogenicity; transmission; animal model

期刊名称： National Science Review

ISSN： 2095-5138

年卷期： 2021 年

页码：

收录情况： JCR（2021版） ; EI（2021版） ; CSCD（2020-2021年度） ; 科技核心（2020版）

摘要： Minks are raised in many countries and have transmitted severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) to humans. However, the biologic properties of SARS-CoV-2 in minks are largely unknown. Here, we investigated and found that SARS-CoV-2 replicates efficiently in both the upper and lower respiratory tracts, and transmits efficiently in minks via respiratory droplets; pulmonary lesions caused by SARS-CoV-2 in minks are similar to those seen in humans with COVID-19. We further found that a spike protein-based subunit vaccine largely prevented SARS-CoV-2 replication and lung damage caused by SARS-CoV-2 infection in minks. Our study indicates that minks are a useful animal model for evaluating the efficacy of drugs or vaccines against COVID-19 and that vaccination is a potential strategy to prevent minks from transmitting SARS-CoV-2.

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