数字农科院2.0

Recombinant characteristics, pathogenicity, and viral shedding of a novel PRRSV variant derived from twice inter-lineage recombination

文献类型： 外文期刊

作者： Xing Yang Cui;Da Song Xia;Xin Yi Huang;Xiao Xiao Tian;Tao Wang;Yong Bo Yang;Gang Wang;Hai Wei Wang;Yue Sun;Yi Hong Xiao;Zhi Jun Tian;Xue Hui Cai;Tong Qing An

作者机构：

关键词： Pathogenicity;PRRSV;Recombination;Virus distribution;Virus shedding

期刊名称： VETERINARY MICROBIOLOGY

ISSN： 0378-1135

年卷期： 2022 年 271 卷

页码：

收录情况： SCIE（2022版）

摘要： Porcine reproductive and respiratory syndrome (PRRS), caused by the PRRS virus (PRRSV), is a significant threat to the global pig industry. In this study, a novel recombinant PRRSV, SD043, was isolated from a pig farm experiencing disease in 2019. Phylogenetic analysis revealed that SD043 belonged to lineage 1 of PRRSV-2 while recombination analyses revealed that it is a recombinant virus from lineage 1 and lineage 8 strains. Based on further analysis, SD043 underwent recombination twice. Pathogenicity studies revealed that SD043 causes mild clinical symptoms, thymus atrophy, and severe histopathological lesions in the lungs. Notably, virus shedding in SD043-infected piglets was detectable at 10 days post-inoculation with a high viral load in the respiratory or digestive tract, indicating that the recombinant PRRSV appears to shed higher numbers of virus. Furthermore, genomic surveillance based on all available PRRSVs circulating in Shandong province revealed an increasing increase in recombinant PRRSV since 2015, with the recombinant pattern (between lineages 1 and 8) being the same as that of SD043. These findings enable a better understanding of the process of twice recombination and virus shedding of recombinant PRRSV and can strengthen the prevention and control of the PRRSV epidemic.

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