数字农科院2.0

Hericium erinaceus polysaccharides (HEP) protect against gastric mucosa injury via modulating inflammatory factors, promoting antioxidant activity, and activating the PI3K-AKT pathway

文献类型： 外文期刊

作者： Weijun Cui;Xiangyang Zhu;Xueping Li;Xinling Song;Le Jia;Chen Zhang

作者机构：

关键词： Gastric mucosal injury;Hericium erinaceus;NO;PI3K/AKT;Polysaccharides

期刊名称： Food Innovation and Advances

ISSN： 2836-774X

年卷期： 2025 年 4 卷 3 期

页码：

收录情况： 无来源刊（2025版）

摘要： Gastric mucosal injury (GMI) is a common pathology affecting many people around the world. Hericium erinaceus polysaccharides (HEP) have various biological activities, such as anti-inflammatory, anti-oxidation, and protection of the gastrointestinal tract. HEP-1, a low molecular weight polysaccharide (1.67 × 104 Da) isolated from Hericium erinaceus, is composed of →6)-β-D-Glcp-(1→, →3)-β-D-Glcp-(1→, β-D-Glcp-(1→, and →3,6)-β-D-Glcp-(1→. However, whether HEP has preventive efficacy against GMI is unknown. This study investigated the intervention effect and potential mechanism of HEP-1 on GMI. Mice treated with HEP-1 for two weeks were treated with ethanol to induce gastric mucosal damage. The gastric mucosal tissue pathology, gastric tissue inflammatory factors, and gastric oxidative stress function were evaluated. The results showed that HEP-1 increased the activity of antioxidant enzymes, reduced the release of inflammatory factors, promoted the production of nitric oxide (NO), inhibited the production of endothelin-1 (ET-1), and increased the blood flow of gastric mucosa to maintain the defensive function of the gastric mucosa. HEP-1 also activated the PI3K-AKT signaling pathway, increased the expression of endothelial nitric oxide synthase (eNOS), promoted the expression of serum and glucocorticoid-induced kinase (SGK), and enhanced the biosynthesis of epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF), thereby facilitating the repair and healing of gastric mucosal injury (GMI). Therefore, HEP-1 has the potential to preserve the integrity of the gastric mucosa and is anticipated to be a key bioactive ingredient in the prevention and repair of GMI.

分类号：

  • 相关文献

[1]Combined metabolomics and proteomics to reveal beneficial mechanisms of Dendrobium fimbriatum against gastric mucosal injury. Sun, Jing,Liu, Peng-Fei,Liu, Jia-Ni,Lu, Cong,Tong, Li-Tao,Wang, Yong-Quan,Liu, Jia-Meng,Fan, Bei,Wang, Feng-Zhong. 2022

[2]Preparation of deer oil powder and its effect on acute gastric mucosal injury in rats. Xia, Yun-Shi,Li, Zhi-Man,Liu, Chang,Mu, Rui,Bo, Pan-Pan,Wang, Zi,Sun, Yin-Shi. 2022

[3]A Resequencing-Based Ultradense Genetic Map Of Hericium Erinaceus For Anchoring Genome Sequences And Identifying Genetic Loci Associated With Monokaryon Growth. Gong, WB, Xie, CL, Zhou, YJ, Zhu, ZH, Wang, YH, Peng, YD. 2020

[4]Whole genome sequence of an edible and medicinal mushroom, Hericium erinaceus (Basidiomycota, Fungi). Zhou, Yingjun,Zhu, Zuohua,Peng, Yuande,Gong, Wenbing,Wang, Yahui,Xie, Chunliang. 2020

[5]Discovery and biochemical characterization of prenyltransferases in the biosynthetic pathway of hericenones from Hericium erinaceus. Haiyan Han,Shuang Peng,Yuxin Yang,Chao Lin,Pengchao Wang,Chang Li,Peipei Zhao,Wenbing Gong,Chunliang Xie,Xuekui Xia,Jianzhao Qi,Chengwei Liu. 2025

[6]The role of melatonin as an antioxidant in human lens epithelial cells. Bai, J.,Dong, L.,Song, Z.,Ge, H.,Liu, P.,Cai, X.,Wang, G..

[7]PI3K/Akt/p53 pathway inhibits reovirus infection. Zhang, Xiaozhan,Wu, Hongxia,Liu, Chunguo,Tian, Jin,Qu, Liandong.

[8]Blocking the PI3K/AKT pathway enhances mammalian reovirus replication by repressing IFN-stimulated genes. Tian, Jin,Zhang, Xiaozhan,Wu, Hongxia,Liu, Chunguo,Li, Zhijie,Hu, Xiaoliang,Qu, Liandong,Su, Shuo,Wang, Lin-Fa. 2015

[9]Changes in PI3K/AKT and NRF2/HO-1 signaling expression and intestinal microbiota in bleomycin-induced pulmonary fibrosis. Chenchen Li,Yuxia Cao,Yousheng Peng,Ting Ma,Fanlin Wu,Yongli Hua,Xiuqin Wang,Tong Bai,Yanming Wei,Peng Ji. 2024

[10]Calotropis procera: a review of molecular mechanisms, bioavailability, and potential anticancer property. Saqib Nawaz,Abdul Wajid,Asif Nawaz,Hanif Ullah,Safia Arbab,Sawar Khan,Aamir Khan,Muhammad Sohail,Abdul Qadeer. 2024

[11]The behavior of the manganese-cerium loaded metal-organic framework in elemental mercury and NO removal from flue gas. Zhang, Xiao,Shen, Boxiong,Zhang, Xiaoqi,Si, Meng,Yuan, Peng,Zhang, Xiao,Shen, Feng.

[12]Nitric oxide affects seed oil accumulation and fatty acid composition through protein S-nitrosation. Jing Liu,Xiao Yi Zhu,Lin Bin Deng,Hong Fang Liu,Jun Li,Xue Rong Zhou,Han Zhong Wang,Wei Hua. 2021

[13]Inositol 1,4,5-Trisphosphate Mediates Nitric-Oxide-Induced Chilling T.olerance And Defense Response I n Postharvest Peach Fruit. Jiao, CF, Chai, YF, Duan, YQ. 2019

[14]Regulation and microbial response mechanism of nitric oxide to copper-containing swine wastewater treated by Pistia stratiotes. Tianbao Hou,Jiahua Liu,Yanpo Yao,Kecheng Chen,Chunchun Mao,Jingwen Zhang,Zhucheng Li,Keqiang Zhang,Peng Yang. 2024

[15]A Database on Antibiotics and Antibiotic Resistance in Wastewater and Solid Waste from Pharmaceutical Industry Based on a Systematic Review. Jingwei Wu,Ziming Han,Xiaomin Ma,Ming Su,Amir Hossein Hamidian,Yu Zhang,Min Yang. 2025

[16]冬季猪粪固体堆放过程中NH_3、N_2O和NO排放特征研究. 丁钢强,韩圣慧,袁玉玲,罗琳,王立刚. 2014

[17]由不同黄单胞病菌诱导的水稻细胞凋亡与坏死特征的分析. 刘佳妮,文景芝,齐放军,吴茂森,何晨阳. 2006

[18]外源NO缓解果树胁迫的作用机理和研究进展. 陈志友,赵樱,江东. 2013

[19]NO和H_2O_2在沙打旺抗黄矮根腐病反应中的互作. 黄贝梅,南志标. 2014

[20]不同剂量钼对绵羊肝脏细胞的损伤作用. 宋超,杨自军,曹晓丹,张鹏,王亚垒,郭书周. 2013

作者其他论文 更多>>