数字农科院2.0

Differential Expression Of Microrna Between Normally Developed And Underdeveloped Female Worms Of Schistosoma Japonicum

文献类型： 外文期刊

作者： Han, Y; Feng, JT; Ren, YQ; Wu, LB; Li, H; Liu, JM; Jin, YM

作者机构：

关键词： Schistosoma Japonicum; Microrna; Deep-Sequencing; Differential Expression; Predicted Target Genes

期刊名称： VETERINARY RESEARCH

ISSN： 0928-4249

年卷期： 2020 年 51 卷 1 期

页码：

收录情况： JCR（2021版）

摘要： Eggs produced by bisexual infected mature female worms (MF) of Schistosoma japonicum are important in the transmission of the parasite and responsible for the pathogenesis of schistosomiasis. The single-sex infected female worms (SF) cannot mature and do not produce normal eggs;; also they do not induce severe damage to the host. In this study, the microRNA (miRNA) expression profiles of 25d MF and 25d SF were investigated through Solexa deep-sequencing technology to explore the developmental mechanisms of schistosome female worms. There were 36 differentially expressed miRNA, 20 up-regulated and 16 down-regulated found in MF/SF worms, including some development related miRNA such as bantam (ban), let-7, miR-124, miR-8, miR-1, miR-7. There were 166 target genes of up-regulated miRNA and 201 target genes of down-regulated miRNA after comparing the target gene prediction software results with RNA-Seq transcriptome results. Analysis of the target genes shows that different ones are involved in MF and SF worms in Gene Ontology terms, with a similar situation in KEGG. This observation indicates that different genes regulated by differentially expressed miRNA take part in MF and SF and lead to differential sexual status. This means that the sexual status of female worms is regulated by miRNA.

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