数字农科院2.0

Review of advanced research on swine Actinobacillus pleuropneumoniae vaccine development strategy

文献类型： 外文期刊

作者： Adehanom Baraki Tesfaye;Rui Han;Zhengyu Tao;Liuchao You;Jiayao Zhu;Pengcheng Gao;Lei Fu;Yuefeng Chu

作者机构：

关键词： Actinobacillus pleuropneumonia;immune protection;toxins;vaccine development;virulencefactors

期刊名称： Frontiers in Immunology

ISSN： 1664-3224

年卷期： 2025 年 16 卷

页码：

收录情况： SCIE（2025版）

摘要： Actinobacillus pleuropneumoniae (App) infection is a major respiratory disease that causes severe economic losses. It is highly infectious and exhibits multiple serotypes, which complicates prevention and control. This review discusses the new-generation vaccine development strategies and the role of virulence factors—such as App toxins, capsular polysaccharide (CPS), lipopolysaccharide (LPS), and outer membrane proteins (OMPs)—in vaccine design. Traditional vaccines offer limited cross-protection, whereas live attenuated vaccines, subunit vaccines, and toxin-based vaccines show promising improvements in efficacy and safety. Current and near-generation subunit and toxin vaccines mainly focus on conserved antigens, incorporating App toxins, OMPs ApfA, and GALT, which significantly enhance cross-protection and safety. Other approaches, including DNA vaccines and combined multivalent vaccines targeting highly prevalent App serotypes and integrating antigens from other pathogens, represent a modern strategy aimed at enhancing cross-serotype protection, minimizing side effects, and enabling differentiating infected from vaccinated animal (DIVA) capability.

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