数字农科院2.0

Gut flora-mediated metabolic health, the risk produced by dietary exposure to acetamiprid and tebuconazole

文献类型： 外文期刊

作者： Liu Jingkun;Zhao Fangfang;Xu Yanyang;Qiu Jing;Qian Yongzhong

作者机构：

关键词： Gut flora; Health risk; Metabolic syndrome; Metabolite; Pesticide residues exposure

期刊名称： Foods

ISSN： 2304-8158

年卷期： 2021 年 10 卷 4 期

页码：

收录情况： JCR（2021版）

摘要： The low-level and long-term exposure of pesticides was found to induce metabolic syndrome to mice. Metabolic pathways and mechanisms were investigated by detecting gut flora with metabolites, host circulation, and their interrelations. Results showed that the abundances of flora species and their metabolism were altered, consequently leading to metabolic disorders. A correlation analysis between gut flora and their metabolic profiling further explained these changes and associations. The metabolic profiling of host circulation was also performed to characterize metabolic disorders. The associations of host circulation with gut flora were established via their significantly different metabolites. Alterations to the liver metabolism clarified potential pathways and mechanisms for the disorders. Metabolic disorders were evidently released by dietary and micro-ecological intervention, directly proving that gut flora comprise a vital medium in metabolic health risk caused by pesticide exposure. This work supplied theoretical bases and intervention approaches to body metabolic problems caused by pesticide exposure mediated by gut flora. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

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