数字农科院2.0

FGF22 Secreted by Hair Papilla Cells Regulates Hair Follicle Stem Cell Proliferation and Differentiation

文献类型： 外文期刊

作者： Yu Luo;Tong Xiao;Binpeng Xi;Yufang Song;Zengkui Lu;Chao Yuan;Jianbin Liu;Tingting Guo

作者机构：

关键词： co-culture;dermal papilla cells;FGF22;hair follicle;hair follicle stem cells

期刊名称： Biomolecules

ISSN： 2218-273X

年卷期： 2025 年 15 卷 11 期

页码：

收录情况： SCIE（2025版）

摘要： Hair follicle stem cells (HFSCs) are resident stem cells within hair follicles (HFs) that possess self-renewal and differentiation capacities, serving as a critical model for regenerative medicine research. Their dynamic interaction with dermal papilla cells (DPCs) plays a decisive role in HF development and cycling. FGF22 is a paracrine fibroblast growth factor that can regulate the proliferation, differentiation and migration of epithelial cells. This study established a DPC-HFSC co-culture system, revealing that FGF22 overexpression in DPCs significantly upregulated FGFR1/FGFR2 mRNA expression levels in HFSCs (p < 0.05), with a 1.67-fold increase in EdU-positive cell proportion (p < 0.01). CCK-8 assays demonstrated markedly enhanced HFSC viability (p < 0.01), with a 17% reduction in HFSC apoptosis (p < 0.05). Conversely, FGF22 knockout downregulated FGFR1/FGFR2 expression (p < 0.05), reduced HFSC proliferation capacity by 25% (p < 0.01), and increased HFSC apoptosis levels by 1.81-fold (p < 0.05). In addition, FGF22 overexpression promotes the proliferation and differentiation of HFSCs by activating Wnt/β-Catenin, Sonic Hedgehog (Shh) and Notch signaling pathways, or inhibiting BMP signaling pathways. Knockout of FGF22 weakens these processes and inhibits the activation and differentiation of HFSCs. This study, through the DPCs-HFSCs co-culture system, revealed the regulatory mechanism of FGF22 secreted by DPCs on the proliferation and differentiation of HFSCs, thereby providing theoretical references for fields such as fine-wool sheep breeding, human regenerative medicine, and hair loss treatment.

分类号：

  • 相关文献

[1]FGF20 Secreted From Dermal Papilla Cells Regulate the Proliferation and Differentiation of Hair Follicle Stem Cells in Fine-Wool Sheep. Song, Yali,Li, Yuhang,Lu, Zengkui,Yue, Lin,Xiao, Tong,Yang, Bohui,Liu, Jianbin,Yuan, Chao,Guo, Tingting. 2024

[2]Effects of TGFBR1 on Proliferation of Dermal Papilla Cells in Fine-Wool Sheep. Xiao, Tong,Luo, Yu,Yuan, Chao,Song, Yufang,Tang, Jianxiang,Lu, Zengkui,Liu, Jianbin,Guo, Tingting. 2025

[3]Epigallocatechin-3-Gallate Promotes The Growth Of M.ink Hair Follicles Through S onic Hedgehog And Protein Kinase B Signaling Pathways. Zhang, HH, Nan, WX, Wang, SY, Song, XC, Si, HZ, Li, T, Li, GY. 2018

[4]Epidermal growth factor promotes proliferation of dermal papilla cells via Notch signaling pathway. Zhang, Haihua,Wang, Shiyong,Zhang, Tietao,Wang, Datao,Yang, Fuhe,Li, Guangyu,Nan, Weixiao,Si, Huazhe. 2016

[5]Integrated analysis of lncrna and mrna reveals novel insights into wool bending in zhongwei goat. Xiaobo Li,Zhanfa Liu,Shaohui Ye,Yue Liu,Qian Chen,Weijun Guan,Yabin Pu,Lin Jiang,Xiaohong He,Yuehui Ma,Qianjun Zhao. 2021

[6]Knockdown Of Hif-1 Alpha Inhibits T.he Proliferation And Migration O f Outer Root Sheath Cells Exposed To Hypoxia In Vitro: An Involvement Of Shh Pathway. Zhang, HH, Nan, WX, Song, XC, Wang, SY, Si, HZ, Li, GY. 2017

[7]Construction of transcriptome atlas of white yak hair follicle during anagen and catagen using single-cell RNA sequencing. Qingbo Zheng,Na Ye,Pengjia Bao,Xiaolan Zhang,Fubin Wang,Lanhua Ma,Min Chu,Xian Guo,Chunnian Liang,Heping Pan,Ping Yan. 2022

[8]Role of Csdc2 in Regulating Secondary Hair Follicle Growth in Cashmere Goats. Heqing Zhu,Yingying Li,He Xu,Yuehui Ma,Göran Andersson,Erik Bongcam-Rudloff,Tiantian Li,Jie Zhang,Yan Li,Jilong Han,Min Yang. 2024

[9]Combining multiomics to analyze the molecular mechanism of hair follicle cycle change in cashmere goats from Inner Mongolia. Chongyan Zhang,Qing Qin,Zhichen Liu,Yichuan Wang,Mingxi Lan,Dan Zhao,Jingwen Zhang,Zhixin Wang,Jinquan Li,Zhihong Liu. 2024

[10]Maternal Melatonin Contributes to Offspring Hair Follicle Development Through Transcriptional Regulation of the AP-1 Complex and MAPK Pathway. Yang Feng,Ruixin Yang,Jianqiang Zhang,Haonan Yuan,Zunqiang Yan,Pengfei Wang,Xiaochun Ma,Ting Liu,Shuangbao Gun. 2025

[11]Identifying the active components and mechanisms of Persicae Semen in treating androgenetic alopecia: Insights from network pharmacology and experimental evaluations. Xiaojuan Li,Xiaoli Liu,Bin Li,Ziyi Liu,Shiqi Guo,Sha Xiong,Ting Xiao,Siwen Jiao,Yu Chen,Yuehong Xu. 2025

[12]The endoplasmic reticulum stress inducer thapsigargin enhances the toxicity of ZnO nanoparticles to macrophages and macrophage-endothelial co-culture. Chen, Gui,Shen, Yuexin,Li, Xiyue,Jiang, Qin,Cheng, Shanshan,Gu, Yuxiu,Cao, Yi,Liu, Liangliang.

[13]Production of a lignocellulolytic enzyme system for simultaneous bio-delignification and saccharification of corn stover employing co-culture of fungi. Ma, Kedong,Ruan, Zhiyong.

[14]Proteome analysis for antifungal effects of Bacillus subtilis KB-1122 on Magnaporthe grisea P131. Zhang, Caixia,Zhang, Caixia,Shen, Shihua,Zhang, Caixia,Zhang, Xinxiong.

[15]Effect of mouse cumulus cells on the in vitro maturation and developmental potential of bovine denuded germinal vesicle oocytes. Zhao, Xue-Ming,Ren, Jing-Jing,Du, Wei-Hua,Hao, Hai-Sheng,Liu, Yan,Qin, Tong,Wang, Dong,Zhu, Hua-Bin.

[16]Variations in soil nutrient dynamics and their composition in rice under integrated rice-crab co-culture system. Muhammad Amjad Bashir,Hongyuan Wang,Junting Pan,Benyamin Khoshnevisan,Wentao Sun,Limei Zhai,Xiushuang Zhang,Na Wang,Abdur Rehim,Hongbin Liu. 2021

[17]The implementation of rice-crab co-culture system to ensure cleaner rice and farm production. Muhammad Amjad Bashir,Hongyuan Wang,Wentao Sun,Limei Zhai,Xiushuang Zhang,Na Wang,Abdur Rehim,Qurat Ul Ain Raza,Hongbin Liu. 2021

[18]THE INFLUENCE OF RICE-DUCK FARM SOIL ON THE NITROGEN CONTENT OF DIFFERENT VARIETIES OF JAPONICA RICE. EBISSA, T. C. H. I. S. T. E. R. M. O. R. R. E. L.,YANG, B. O.,VINDUSKOVA, O. L. G. A.,GAO, Y. I.,GONG, Q. I. O. N. G.,ZHENG, X. I. A. N. G. Q. U. N.. 2022

[19]Integrated rice-crab co-culture system shows capability to reduce greenhouse gases emission and global warming potential. Muhammad Amjad Bashir,Yang Xu,Hongyuan Wang,Yibin Zhang,Qurat ul Ain Raza,Wentao Sun,Muhammad Aon,Xiushuang Zhang,Abdur Rehim,Hongbin Liu. 2025

[20]Lactic acid bacteria and yeast co-culture system: Mechanism of quorum-sensing regulation on the high yield of exopolysaccharides in Weissella confusa. Wenna Yu,Ziwen Wang,Huiran Zhao,Yang Qiu,Zehai Chen,Jingping Ge,Renpeng Du. 2025

作者其他论文 更多>>