数字农科院2.0

Early-Life Galacto-Oligosaccharide Supplementation Induces Persistent Immunoglobulin and Metabolic Alterations in Holstein Dairy Calves by Shaping Gut Microbiota

文献类型： 外文期刊

作者： Huang, Qi;Chang, Meinan;Sun, Peng

作者机构：

关键词： galacto-oligosaccharides;immunity;gut microbiota;dairy calves;metabolomics

期刊名称： ANIMALS

ISSN： 2076-2615

年卷期： 2026 年 16 卷 1 期

页码：

收录情况： SCIE（2025版）

摘要： Early-life development of immune functions is crucial for calf health, growth, and future productivity. Galacto-oligosaccharides (GOSs) have been reported to facilitate ruminal microbial establishment and improve growth in Holstein dairy calves, but their prolonged influence on immunoglobulin levels, hindgut microbiota, and metabolic regulation remains insufficiently understood. This study evaluated the effects of early-life GOS supplementation on immune-related indicators, intestinal microbial ecology, and metabolic profiles in Holstein calves. Twenty-four newborn Holstein female dairy calves were randomly assigned to a control group (CON, n = 12) or a GOS group (GOS, n = 12; 10 g/day from birth to day 28). After supplementation ceased on day 28, calves previously receiving GOS were referred to as the GOSS group (n = 6). Immunoglobulin levels, gut microbiota, and fecal and serum metabolomes were evaluated during supplementation and six weeks after withdrawal. GOS supplementation significantly increased serum IgA and IgG levels during the treatment, with IgG levels remaining elevated for six weeks after discontinued supplementation. Although overall microbial diversity was not markedly altered, GOS selectively enriched bacterial taxa and function pathways linked to amino acid synthesis, unsaturated fatty acid production, and coenzyme-related metabolism. On day 70, GOSS group displayed distinct fecal and serum metabolomic profiles, with altered metabolites primarily associated with vitamin B6, folate, cobalamin metabolism, branched-chain amino acid biosynthesis, and purine and arginine pathways. These results demonstrate that early-life GOS supplementation promotes sustained immune and metabolic alterations following supplementation cessation, potentially mediated by modulation of gut microbial functions. These findings suggest that early dietary GOS supplementation may support physiological maturation in calves and could be useful as a nutritional strategy in calf-rearing systems.

分类号：

  • 相关文献

[1]Effects of Different Galacto-Oligosaccharide Supplementation on Growth Performance, Immune Function, Serum Nutrients, and Appetite-Related Hormones in Holstein Calves. Xin Yu,Fengtao Ma,Haonan Dai,Junhao Liu,Nesrein M. Hashem,Peng Sun. 2023

[2]Integrated Metabolomics and Transcriptome Revealed the Effect of Fermented Lycium barbarum Residue Promoting Ovis aries Immunity. Yajun Zhang,Yansheng Guo,Yulong Luo,Min Du,Xin Yin,Xiaochun Xu,Guijie Zhang. 2022

[3]Yeast cell-wall polysaccharides improve immunity and attenuate inflammatory response via modulating gut microbiota in LPS-challenged laying hens. Zhou, Jianmin,Fu, Yu,Qi, Guanghai,Dai, Jinjun,Zhang, Haijun,Wang, Jing,Wu, Shugeng. 2023

[4]Gut microbiota bridges dietary nutrients and host immunity. Fan, Lijuan,Xia, Yaoyao,Wang, Youxia,Han, Dandan,Liu, Yanli,Li, Jiahuan,Fu, Jie,Wang, Leli,Gan, Zhending,Liu, Bingnan,Fu, Jian,Zhu, Congrui,Wu, Zhenhua,Zhao, Jinbiao,Han, Hui,Wu, Hao,He, Yiwen,Tang, Yulong,Zhang, Qingzhuo,Wang, Yibin,Zhang, Fan,Zong, Xin,Yin, Jie,Zhou, Xihong,Yang, Xiaojun,Wang, Junjun,Yin, Yulong,Ren, Wenkai. 2023

[5]Effects of Dietary Supplementation With Bacillus subtilis, as an Alternative to Antibiotics, on Growth Performance, Serum Immunity, and Intestinal Health in Broiler Chickens. Qiu, Kai,Li, Cheng-liang,Wang, Jing,Qi, Guang-hai,Gao, Jun,Zhang, Hai-jun,Wu, Shu-geng. 2021

[6]Potential role of the gut microbiota of bumblebee Bombus pyrosoma in adaptation to high-altitude habitats. Zhang, Zhengyi,Guo, Yulong,Zhuang, Mingsheng,Liu, Fugang,Xia, Zhongyan,Zhang, Zhihao,Yang, Fan,Zeng, Huayan,Wu, Yueguo,Huang, Jiaxing,Li, Jilian. 2023

[7]Influences of dietary Eucommia ulmoides leaf extract on the hepatic lipid metabolism, inflammation response, intestinal antioxidant capacity, intestinal microbiota, and disease resistance of the channel catfish (Ictalurus punctatus). Feng Li Zhang,Qiang Hao,Qing shuang Zhang,Hui Yuan Lv,Ya Lin Yang,Chao-Ran,Zhen Zhang,Zhi Gang Zhou. 2022

[8]Effects of solid-state fermentation product of yeast supplementation on liver and intestinal health, and resistance of common carp (Cyprinus carpio) against spring viraemia carp virus. Mengxin Wang,Dongmei Xia,Lijuan Yu,Qiang Hao,Mingxu Xie,Qingshuang Zhang,Yajie Zhao,Delong Meng,Yalin Yang,Chao Ran,Tsegay Teame,Zhen Zhang,Zhigang Zhou. 2024

[9]Dietary Bacillus velezensis T23 fermented products supplementation improves growth, hepatopancreas and intestine health of Litopenaeus vannamei. Hongwei Yang,Dongdong Du,Qingshuang Zhang,Tsegay Teame,Anran Wang,Qiang Hao,Shubin Liu,Qianwen Ding,Yuanyuan Yao,Yalin Yang,Chao Ran,Shengkang Li,Zhen Zhang,Zhigang Zhou. 2024

[10]ProtectiveimmunityinducedbyaDNAvaccineexpressingeIF4AofToxoplasmagondiiagainstacutetoxoplasmosisinmice. 陈佳,SiyangHuang,ZhongyuanLi,ZiguoYuan,DonghuiZhou,EskildPetersen,NianzhangZhang,XingquanZhu. 2013

[11]表达H3N8亚型马流感病毒重组禽痘病毒载体疫苗的研究. 戚亭,郭巍,王晓钧. 2015

[12]Gut microbiota-driven regulation of queen bee ovarian metabolism. Li, Wan-Li,Huang, Qi,Li, Jia-Li,Wu, Ping,Wei, Bangrong,Li, Xi-Jie,Tang, Qi-He,Dong, Zhi-Xiang,Xiong, Jian,Tang, Hong,Zhang, Jun,Zhao, Chong-Hui,Cao, Zhe,Chen, Yuan,Zhao, Wen-zheng,Wang, Kai,Guo, Jun. 2023

[13]Impact of Clarified Apple Juices with Different Processing Methods on Gut Microbiota and Metabolomics of Rats. Lei Xu,Shini Yang,Kewen Wang,Anjing Lu,Xue Wang,Zhenzhen Xu. 2022

[14]Systems Biology Approaches for Understanding Metabolic Differences Using 'Multi-Omics' Profiling of Metabolites in Mice Fed with Honey and Mixed Sugars. Zheng, Xing,Zhao, Yazhou,Naumovski, Nenad,Zhao, Wen,Yang, Guan,Xue, Xiaofeng,Wu, Liming,Granato, Daniel,Peng, Wenjun,Wang, Kai. 2022

[15]Saccharomyces boulardii protects against murine experimental colitis by reshaping the gut microbiome and its metabolic profile. Hui Gao,Yinzheng Li,Jiqu Xu,Xuezhi Zuo,Tiantian Yue,Huzi Xu,Jie Sun,Meng Wang,Ting Ye,Yan Yu,Ying Yao. 2023

[16]Nodakenin Ameliorates Ovariectomy-Induced Bone Loss by Regulating Gut Microbiota. Chunxiao Liu,Jingyue Chen,Zijiao Wang,Yueyao Li,Yuanyuan Zhang,Guangyu Li. 2024

[17]Dietary Flavonoid Quercetin Supplement Promotes Antiviral Innate Responses Against Vesicular Stomatitis Virus Infection by Reshaping the Bacteriome and Host Metabolome in Mice. Li, Tingting,Zhu, Jinfeng,Yu, Qifeng,Zhu, Yinrui,Wu, Chao,Zheng, Xing,Chen, Nannan,Pei, Pei,Yang, Kai,Wang, Kai,Hu, Lin. 2024

[18]Queen Bee Larva, an Edible By-Product of Royal Jelly, Alleviate D-Galactose-Induced Aging in Mouse by Regulating Gut Microbiota Structure and Amino Acid Metabolism. Tong Zhao,Xiaofeng Xue,Pingxiang Liu,Han Hu,Kai Wang,Yutao Wang,Liming Wu. 2024

[19]Utilizing Lactic Acid Bacteria to Improve Hyperlipidemia: A Comprehensive Analysis from Gut Microbiota to Metabolic Pathways. Changlu Ma,Chen Xu,Mumin Zheng,Shuwen Zhang,Qifeng Liu,Jiaping Lyu,Xiaoyang Pang,Yinghong Wang. 2024

[20]Gut microbiota regulates the brain metabolism of sexually mature drones. Zhang, Jun,Zhao, Ya-Zhou,Hou, Meng-Shang,Tang, Qi-He,Pang, Yan-Tao,Li, Xi-Jie,Xiong, Jian,Zhao, Chong-Hui,Huang, Qi,Tian, Shao-Jiang,Dong, Zhi-Xiang,Liu, Zhen-Xing,Guo, Jun. 2025

作者其他论文 更多>>