数字农科院2.0

Ginsenoside Rg5 Activates the LKB1/AMPK/mTOR Signaling Pathway and Modifies the Gut Microbiota to Alleviate Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet

文献类型： 外文期刊

作者： Yingying Shi;Jianbo Chen;Di Qu;Qiang Sun;Yang Yu;Hao Zhang;Zhengbo Liu;Jiyue Sha;Yinshi Sun

作者机构：

关键词： fecal microbiota transplantation;ginsenoside Rg5;LKB1/AMPK/mTOR signaling pathway;nonalcoholic fatty liver disease

期刊名称： Nutrients

ISSN： 2072-6643

年卷期： 2024 年 16 卷 6 期

页码：

收录情况： SCIE（2024版）

摘要： The primary objective of this investigation was to elucidate the manner in which ginsenoside Rg5 (Rg5) ameliorates nonalcoholic fatty liver disease (NAFLD) via the modulation of the gut microbiota milieu. We administered either a standard diet (ND) or a high-fat diet (HFD), coupled with 12-week treatment employing two distinct doses of Rg5 (50 and 100 mg/kg/d), to male C57BL/6J mice. In comparison to the HFD cohort, the Rg5-treated group demonstrated significant enhancements in biochemical parameters, exemplified by a substantial decrease in lipid concentrations, as well as the reduced expression of markers indicative of oxidative stress and liver injury. This signifies a mitigation of hepatic dysfunction induced by an HFD. Simultaneously, Rg5 demonstrates the capacity to activate the LKB1/AMPK/mTOR signaling pathway, instigating energy metabolism and consequently hindering the progression of NAFLD. Furthermore, we underscored the role of Rg5 in the treatment of NAFLD within the gut-microbiota-liver axis. Analysis via 16S rRNA sequencing unveiled that Rg5 intervention induced alterations in gut microbiota composition, fostering an increase in beneficial bacteria, such as Bacteroides and Akkermansia, while concurrently reducing the relative abundance of detrimental bacteria, exemplified by Olsenella. Furthermore, employing fecal microbiota transplantation (FMT) experiments, we observed analogous outcomes in mice subjected to fecal bacterial transplants, providing additional verification of the capacity of Rg5 to mitigate NAFLD in mice by actively participating in the restoration of gut microbiota via FMT. Drawing from these data, the regulation of the gut microbiota is recognized as an innovative strategy for treating or preventing NAFLD and metabolic syndrome. Consequently, these research findings suggest that Rg5 holds promise as a potential therapeutic agent for NAFLD management.

分类号：

  • 相关文献

[1]A Novel Process for One-Step Separation and Cyclodextrin Inclusion of Ginsenoside Rg5 from Ginseng Stem–Leaf Saponins (GSLS): Preparation, Characterization, and Evaluation of Storage Stability and Bioactivity. Jianbo Chen,Meijia Li,Xiaohui Huo,Zhiman Li,Di Qu,Jiyue Sha,Yinshi Sun. 2023

[2]Optimized Rapeseed Oils Rich in Endogenous Micronutrients Protect High Fat Diet Fed Rats from Hepatic Lipid Accumulation and Oxidative Stress. Xu, Jiqu,Liu, Xiaoli,Deng, Qianchun,Huang, Qingde,Huang, Fenghong,Xu, Jiqu,Liu, Xiaoli,Deng, Qianchun,Huang, Qingde,Huang, Fenghong,Gao, Hui,Chen, Chang,Chen, Chang,Ma, Zhonghua. 2015

[3]Effects of several tea extracts on nonalcoholic fatty liver disease in mice fed with a high-fat diet. Qian-Qian Mao,Bang-Yan Li,Jin-Ming Meng,Ren-You Gan,Xiao-Yu Xu,Ying-Ying Gu,Xiao-Hui Wang,Hua-Bin Li. 2021

[4]Plant sterol ester of ?-linolenic acid improves NAFLD through modulating gut microbiota and attenuating lipopolysaccharide-induced inflammation via regulating TLR4/NF-?B signaling pathway. Han, Hao,Wang, Linqi,Xue, Tingli,Li, Jie,Pei, Liyuan,Zheng, Mingming. 2022

[5]Protection against Metabolic Associated Fatty Liver Disease by Protocatechuic Acid. Jijun Tan,Ruizhi Hu,Jiatai Gong,Chengkun Fang,Yanli Li,Ming Liu,Ziyu He,De Xing Hou,Hongfu Zhang,Jianhua He,Shusong Wu. 2023

[6]Improving fatty liver hemorrhagic syndrome in laying hens through gut microbiota and oxylipin metabolism by Bacteroides fragilis: A potential involvement of arachidonic acid. Shaobo Zhang,Manhua You,Youming Shen,Xinghua Zhao,Xin He,Juxiang Liu,Ning Ma. 2025

[7]Washed Microbiota Transplantation Vs. Manual Fecal Microbiota Transplantation: Clinical Findings, Animal Studies And In Vitro Screening. Zhang, Faming,Yin, Haoran,Zhang, Faming,Zhang, Faming,Wang, Huiquan,Marcella, Cicilia,Lu, Gaochen,Shen, Quan,Marcella, Cicilia,Zhao, Zhe,Chen, Yaoyao,Zhang, Ting,Cheng, Lei,Chen, Yaoyao,Zhang, Ting,Cui, Bota,Li, Pan,Cheng, Lei,Cui, Bota,Lu, Gaochen,Ji, Guozhong,Ji, Guozhong,Liu, Yafei,Li, Pan,Liu, Yafei. 2020

[8]Gut microbiota implications for health and welfare in farm animals: A review. Siyu Chen,Shuyan Luo,Chao Yan. 2022

[9]Microbiota From Alginate Oligosaccharide-Dosed Mice Successfully Mitigated Small Intestinal Mucositis. Zhang, PF, Liu, J, Xiong, BH, Zhang, C, Kang, BN, Gao, YS, Li, ZK, Ge, W, Cheng, SF, Hao, YN, Shen, W, Yu, S, Chen, L, Tang, XF, Zhao, Y, Zhang, HF. 2020

[10]Diversity of the fecal microbiota in Chinese ponies. Shipeng Lv,Yanli Zhang,Zhengkai Zhang,Sihan Meng,Yabin Pu,Xuexue Liu,Lingling Liu,Yuehui Ma,Wujun Liu,Lin Jiang. 2023

[11]Polygonum sibiricum polysaccharides exert the antidepressant-like effects in chronic unpredictable mild stress-induced depressive mice by modulating microbiota-gut-brain axis. Zhang, Yingyu,Sun, Yuan,Liu, Yupei,Liu, Jiameng,Sun, Jing,Liu, Xinmin,Fan, Bei,Lu, Cong,Wang, Fengzhong. 2023

[12]Plateau pika fecal microbiota transplantation ameliorates inflammatory bowel disease manifestations in a mouse model of colitis. Yang, Yayuan,Cui, Baiqiang,Lv, Yanan,Lu, Xiangnan,Shen, Wenxiang,Feng, Min,Ding, Xuezhi,Dong, Pengcheng,Wang, Yu. 2023

[13]Male-Biased Gut Microbiome and Metabolites Aggravate Colorectal Cancer Development. Wang, Ling,Tu, Yi-Xuan,Chen, Lu,Zhang, Yuan,Pan, Xue-Ling,Yang, Shu-Qiao,Zhang, Shuai-Jie,Li, Sheng-Hui,Yu, Ke-Chun,Song, Shuo,Xu, Hong-Li,Yin, Zhu-Cheng,Yue, Jun-Qiu,Ni, Qian-Lin,Tang, Tang,Zhang, Jiu-Liang,Guo, Min,Zhang, Shuai,Yao, Fan,Liang, Xin-Jun,Chen, Zhen-Xia. 2023

[14]Fecal microbiota transplantation provides insights into the consequences of transcriptome profiles and cell energy in response to circadian misalignment of chickens. Siyu Chen,Hao Liu,Chao Yan,Yushan Li,Jinlong Xiao,Xingbo Zhao. 2024

[15]Yellow leaf green tea modulates the AMPK/ACC/SREBP1c signaling pathway and gut microbiota in high-fat diet-induced mice to alleviate obesity. Tian, Baoming,Pan, Yizhu,Zhou, Xue,Jiang, Yuezhi,Zhang, Xiangchun,Luo, Xudong,Yang, Kai. 2024

[16]Alteration in the Gut Microbiota of Chickens Resistant to Eimeria tenella Infection. Yu Qiao,Qian Feng,Qingjie Wang,Qiping Zhao,Shunhai Zhu,Fanghe Zhao,Zhongchuang Wang,Ruiting Zhang,Jinwen Wang,Yu Yu,Hongyu Han,Hui Dong. 2024

[17]Mangosteen Pericarp Extract Mitigates Diquat-Induced Hepatic Oxidative Stress by NRF2/HO-1 Activation, Intestinal Barrier Integrity Restoration, and Gut Microbiota Modulation. Weichen Huang,Yujie Lv,Chenhao Zou,Chaoyue Ge,Shenao Zhan,Xinyu Shen,Lianchi Wu,Xiaoxu Wang,Hongmeng Yuan,Gang Lin,Dongyou Yu,Bing Liu. 2025

[18]Yeast β-glucan ameliorated Salmonella-induced gut impairment in broiler chickens by modulating gut microbiome. Ruichen Bi,Waseem Abbas,Juan Li,Jia Huang,Jinming Hu,Fangshen Guo,Zhong Wang. 2025

[19]Effects and Microbiota Changes Following Oral Lyophilized Fecal Microbiota Transplantation Capsules in Canine with Chronic Enteropathy After Parvovirus Infection: Case Report. Siyu Liu,Baihui Zhou,Lei Liu,Jialai Zhong,Xinyan Zhang,Wenting Jiang,Haifeng Liu,Ziyao Zhou,Guangneng Peng,Yalin Zhong,Kun Zhang,Zhijun Zhong. 2025

作者其他论文 更多>>